TMEM86A and MS4A2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM86A	MS4A2
Description		transmembrane protein 86A	membrane spanning 4-domains A2
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Plasma Membrane External Side Of Plasma Membrane Membrane Fc-epsilon Receptor I Complex
	Molecular Function	Protein Binding Hydrolase Activity Alkenylglycerophosphocholine Hydrolase Activity	Protein Binding IgE Binding
	Biological Process	Lipid Metabolic Process	Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway
Pathways			Fc epsilon receptor (FCERI) signaling Fc epsilon receptor (FCERI) signaling Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization FCERI mediated NF-kB activation
Drugs			Omalizumab
Diseases			Asthma
GWAS		Ovarian reserve ( 22116950)	Alzheimer's disease ( 31473137)
Interacting Genes		48 interacting genes: AQP2 AQP3 BCL2L13 CD79A CISD2 CNR2 COQ9 CPLX4 CREB3L1 EBP ERGIC3 FAM209A FFAR2 FKBP7 FNDC9 FXYD3 GJB4 GJB5 GJC1 GORAB GPR37L1 GPX8 HAVCR2 KASH5 KCNA1 LHFPL5 LMNA MS4A2 MUC1 NCAPH2 PDZK1IP1 PGRMC2 PI16 REEP4 RIC3 RNF185 SCN3B SLC10A6 SLC18A1 SLC30A2 SLC35H1 SLC39A2 SSMEM1 THAP4 TIMMDC1 TMEM31 TMPRSS2 TYROBP	12 interacting genes: AKT1 APP FCER1A GRB2 HSP90AA1 LYN PRKCD PTPN11 PTPN6 SNCA SYK TMEM86A
Entrez ID		144110	2206
HPRD ID		08292	00915
Ensembl ID		ENSG00000151117	ENSG00000149534
Uniprot IDs		Q8N2M4	A0A0B4J2E9 Q01362
PDB IDs			8YVU 8YWA
Enriched GO Terms of Interacting Partners?		Membrane Transmembrane Transport Protein Binding Connexin Complex Gap Junction Channel Activity Gap Junction Glycerol Transmembrane Transport Monoatomic Ion Transport Renal Water Transport Endoplasmic Reticulum Polyol Transmembrane Transport Atrial Cardiac Muscle Cell Action Potential Transport Vesicle Membrane	Regulation Of Defense Response Regulation Of Cell Activation Regulation Of Immune Response Immune Effector Process Regulation Of Immune System Process Regulation Of Innate Immune Response T Cell Costimulation Myeloid Leukocyte Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune System Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Leukocyte Activation Positive Regulation Of Immune System Process Cell Activation Positive Regulation Of Cell Activation Neutrophil Activation Immune Response-regulating Signaling Pathway Activation Of Immune Response Protein-containing Complex Positive Regulation Of Defense Response Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of T Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Reactive Oxygen Species Metabolic Process Phosphotyrosine Residue Binding Regulation Of Cell Adhesion Mediated By Integrin B Cell Receptor Signaling Pathway Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Fc Receptor Signaling Pathway Neutrophil Activation Involved In Immune Response Immune Response-activating Signaling Pathway Response To Stress Regulation Of Transport Regulation Of MAPK Cascade Positive Regulation Of Immune Response Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Regulation Of Inflammatory Response Activation Of Innate Immune Response Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein Localization Protein Kinase Binding Positive Regulation Of Superoxide Anion Generation Regulation Of Cell Adhesion Regulation Of Superoxide Anion Generation Positive Regulation Of Transport Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Response To External Biotic Stimulus
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