NR2E3 and CRX

Number of citations of the paper that reports this interaction (PMID 15689355)
63

Data Source:
HPRD (in vivo, two hybrid)

		NR2E3	CRX
Gene Name		nuclear receptor subfamily 2, group E, member 3	cone-rod homeobox
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex	Nucleus Transcription Factor Complex
	Molecular Function	Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Nuclear Hormone Receptor Binding Leucine Zipper Domain Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Visual Perception Phototransduction Negative Regulation Of Cell Proliferation Gene Expression Intracellular Receptor Signaling Pathway Eye Photoreceptor Cell Development Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Rhodopsin Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Retina Development In Camera-type Eye	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Visual Perception Circadian Rhythm Organ Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Photoreceptor Cell Differentiation Response To Stimulus Retina Development In Camera-type Eye
Pathways
Drugs
Diseases
GWAS		Metabolite levels (HVA/MHPG ratio) ( 23319000)
Protein-Protein Interactions		27 interactors: BCL11A CDK9 CRX DEDD2 DHX30 ELAVL2 HDAC1 HDAC3 HOXC13 IRF9 MYBBP1A NCOR1 NR1D1 NR3C1 POLR3D PPARG RARA RBBP4 RBBP7 RBFOX2 RBL1 RXRA RXRB SIN3A SNAPC1 TBL3 ZNF232	44 interactors: ABI2 AES ATG12 ATXN7 BANF1 C1orf109 C9orf72 CA8 CCNC CREBBP CSNK1G2-AS1 EIF5A EP300 GCM2 GUCD1 IPO13 KAT2A KIAA0141 KLHL32 LARP4 LONRF1 M1AP MDFI MLLT6 NIP7 NPAS2 NR2E3 NRL OSGIN1 PARK2 PDC PID1 PPP1R16B PRKAB2 PSMB10 QRICH1 RAX2 RBFOX1 ROR2 SFI1 SOX5 STK16 SZT2 UBXN2B
Entrez ID		10002	1406
HPRD ID		05132	03748
Ensembl ID			ENSG00000105392
Uniprot IDs		B6ZGU0 F1D8Q9 Q9Y5X4	O43186
PDB IDs
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process DNA-templated Transcription, Initiation Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Steroid Hormone Mediated Signaling Pathway Intracellular Receptor Signaling Pathway Cellular Metabolic Process Hormone-mediated Signaling Pathway Positive Regulation Of Cellular Metabolic Process Cellular Response To Organic Substance Circadian Regulation Of Gene Expression Circadian Rhythm Rhythmic Process Cellular Response To Steroid Hormone Stimulus Chromatin Modification Positive Regulation Of Metabolic Process Chromatin Organization Regulation Of Receptor Biosynthetic Process Response To Organic Substance	Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Positive Regulation Of Rhodopsin Gene Expression N-terminal Peptidyl-lysine Acetylation Regulation Of Rhodopsin Gene Expression Transcription, DNA-templated Visual Perception Sensory Perception Of Light Stimulus Positive Regulation Of Metabolic Process RNA Biosynthetic Process RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Mitochondrial Fusion Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Cellular Process Organelle Organization Negative Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Autophagy N-terminal Protein Amino Acid Acetylation Nuclear Envelope Reassembly Cellular Response To Stimulus Response To Stimulus Negative Regulation Of Wnt Signaling Pathway Cellular Metabolic Process Somitogenesis Cellular Nitrogen Compound Metabolic Process Developmental Process Nucleobase-containing Compound Metabolic Process Transcription From RNA Polymerase II Promoter Histone Deubiquitination Neurological System Process Somite Development Cellular Response To Stress Regulation Of Type I Interferon Production Peptidyl-amino Acid Modification Peptidyl-lysine Modification Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Tagcloud ?		11a causing compound correlates cytotoxic cytotoxicity eralpha excluding facilitate favorable hct116 hela implying isogenic mediator mutated nci null orphan p53 photoreceptor pleiotropic pnr responsive retain retinal systematic tamoxifen varying	5sa aspect cofactor embryos exit hippo lats1 morphogenesis mst1 mst2 neurogenesis orchestrate otx5 phosphorylate photoreceptor pigmentation playing progenitor prolongs remarkably repressing retinal retinogenesis rhodopsin rx1 tead ww yap zebrafish
Tagcloud (Difference) ?		11a causing compound correlates cytotoxic cytotoxicity eralpha excluding facilitate favorable hct116 hela implying isogenic mediator mutated nci null orphan p53 pleiotropic pnr responsive retain systematic tamoxifen varying	5sa aspect cofactor embryos exit hippo lats1 morphogenesis mst1 mst2 neurogenesis orchestrate otx5 phosphorylate pigmentation playing progenitor prolongs remarkably repressing retinogenesis rhodopsin rx1 tead ww yap zebrafish
Tagcloud (Intersection) ?		photoreceptor retinal