NR2E3 and DHX30

Number of citations of the paper that reports this interaction (PubMedID 17255935)
48

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		NR2E3	DHX30
Description		nuclear receptor subfamily 2 group E member 3	DExH-box helicase 30
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Ribonucleoprotein Granule Mitochondrial Nucleoid
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Steroid Receptor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding	Nucleotide Binding G-quadruplex RNA Binding Nucleic Acid Binding DNA Helicase Activity Chromatin Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Signal Transduction Visual Perception Phototransduction Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Neuron Differentiation Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Intracellular Receptor Signaling Pathway Eye Photoreceptor Cell Development Positive Regulation Of Transcription By RNA Polymerase II Retina Development In Camera-type Eye	Central Nervous System Development Ribosome Biogenesis Mitochondrial Large Ribosomal Subunit Assembly
Pathways
Drugs
Diseases		Retinitis pigmentosa (RP) Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC)
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Macular thickness ( 30535121) Metabolite levels (HVA/MHPG ratio) ( 23319000) Red blood cell count ( 32888494)
Interacting Genes		29 interacting genes: BCL11A CDK9 CRX DEDD2 DHX30 ELAVL2 HDAC1 HDAC3 HOXC13 IRF9 MYBBP1A NCOR1 NR1D1 NR3C1 NRL POLR3D PPARG RARA RBBP4 RBBP7 RBFOX2 RBL1 RXRA RXRB SIN3A SNAPC1 TBL3 WDR5 ZNF232	23 interacting genes: CDK9 CFTR DHX58 DUX4 HDAC1 HDAC3 HNRNPD HSPA13 MYBBP1A NCOR1 NEDD4 NEIL3 NR2E3 OAS3 OGT PRPF39 RBBP4 RBBP7 RBL1 SIN3A SKIL TBL3 USP7
Entrez ID		10002	22907
HPRD ID		05132	13142
Ensembl ID		ENSG00000278570	ENSG00000132153
Uniprot IDs		F1D8Q9 Q9Y5X4	H7BXY3 Q7L2E3
PDB IDs		4LOG	2DB2
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process DNA Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription Cis-regulatory Region Binding Nucleus Positive Regulation Of RNA Metabolic Process Histone Deacetylase Complex Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Nuclear Receptor Activity Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Chromatin Binding Hormone-mediated Signaling Pathway DNA-binding Transcription Factor Activity Negative Regulation Of Macromolecule Metabolic Process Transcription By RNA Polymerase II Sequence-specific Double-stranded DNA Binding DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Sin3-type Complex Chromatin Organization Retinoic Acid Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Metabolic Process Retinoic Acid-responsive Element Binding Nucleic Acid Metabolic Process	Negative Regulation Of Biosynthetic Process Histone Deacetylase Complex Negative Regulation Of Macromolecule Biosynthetic Process Sin3-type Complex Negative Regulation Of Stem Cell Population Maintenance Negative Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Rhythmic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Organization Positive Regulation Of Stem Cell Population Maintenance Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Nucleoplasm Negative Regulation Of Transcription By RNA Polymerase II Circadian Rhythm Nucleus Regulation Of Stem Cell Population Maintenance Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Signal Transduction Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of RNA Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Stress Regulation Of Nucleobase-containing Compound Metabolic Process Protein-containing Complex Histone Deacetylase Binding NuRD Complex Regulation Of Gene Expression Transcription Repressor Complex Chromatin Remodeling Response To Stress Circadian Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Primary Metabolic Process Regulation Of Cell Fate Specification Protein Lysine Delactylase Activity Positive Regulation Of Metabolic Process Transcription Corepressor Activity Regulation Of Metabolic Process Protein Decrotonylase Activity Histone Decrotonylase Activity
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