NR2E3 and RBFOX2

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		NR2E3	RBFOX2
Description		nuclear receptor subfamily 2 group E member 3	RNA binding fox-1 homolog 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Steroid Receptor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding	Nucleic Acid Binding Transcription Corepressor Activity RNA Binding MRNA Binding Protein Binding DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Signal Transduction Visual Perception Phototransduction Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Neuron Differentiation Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Intracellular Receptor Signaling Pathway Eye Photoreceptor Cell Development Positive Regulation Of Transcription By RNA Polymerase II Retina Development In Camera-type Eye	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing Nervous System Development RNA Splicing RNA Metabolic Process Estrogen Receptor Signaling Pathway Regulation Of Cell Population Proliferation Regulation Of RNA Splicing Negative Regulation Of DNA-templated Transcription
Pathways			FGFR2 alternative splicing
Drugs
Diseases		Retinitis pigmentosa (RP) Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC)
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Macular thickness ( 30535121) Metabolite levels (HVA/MHPG ratio) ( 23319000) Red blood cell count ( 32888494)	Body size at age 10 ( 32376654) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Reading disability or specific language impairment (pleiotropy) ( 25065397) Red cell distribution width ( 32888494) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		29 interacting genes: BCL11A CDK9 CRX DEDD2 DHX30 ELAVL2 HDAC1 HDAC3 HOXC13 IRF9 MYBBP1A NCOR1 NR1D1 NR3C1 NRL POLR3D PPARG RARA RBBP4 RBBP7 RBFOX2 RBL1 RXRA RXRB SIN3A SNAPC1 TBL3 WDR5 ZNF232	182 interacting genes: ADARB1 ALG13 ANKHD1 APH1A ATN1 ATXN1 ATXN1L BAG4 BOLL C1orf94 CALD1 CAMK2A CAMK2B CHAF1A CHERP CLASP2 CPSF7 DAB1 DAZAP2 DDX21 DDX5 DEDD2 DENND1B DMRTB1 EIF4ENIF1 ELAVL1 ELAVL2 ESR1 ESR2 FAM168B FBXO7 FSAF1 GIMAP4 GLIS2 GTF2A1L H1-4 HMGA1 HNRNPAB HNRNPF HNRNPH1 HNRNPH2 HNRNPK KHDRBS1 KHDRBS2 KIF20A KRT31 KRTAP6-2 LMNA LSM5 MAGED1 MAPK1IP1L MBNL1 MED7 MIR1-1 MIR106A MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-2 MIR140 MIR141 MIR143 MIR155 MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR9-1 MIR9-2 MIR9-3 MIR93 MIRLET7A1 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MRPL4 MSI2 MTG1 MYO1C NAF1 NLGN3 NOL8 NR2E3 NXF1 OGT OXER1 PA2G4 PCBP1 PCBP2 PCNP PDIA3 PEG10 POLR3D PPIL4 PRMT5 PRPF19 PRPF38B PRRC2B PSMA3 PSMF1 PTBP1 PURB QARS1 QKI RBFOX1 RBFOX3 RBM12 RBM17 RBM22 RBM23 RBM42 RBPMS RBPMS2 RERE RHOXF2 RNF8 RPL3 RPL4 RPN1 RPS13 RPS28 SDHC SF1 SF3A1 SF3B3 SF3B4 SMN1 SNRPA SNRPC SNW1 SPATS2L SPMIP9 SPOP SRP68 ST13 SUPV3L1 SURF6 TNRC6A TOLLIP U2AF2 UBQLN2 VAC14 YTHDF1 YTHDF3 ZC3H10 ZNF137P
Entrez ID		10002	23543
HPRD ID		05132	15231
Ensembl ID		ENSG00000278570	ENSG00000100320
Uniprot IDs		F1D8Q9 Q9Y5X4	A0A8Q3WKT3 O43251
PDB IDs		4LOG	2CQ3
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process DNA Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription Cis-regulatory Region Binding Nucleus Positive Regulation Of RNA Metabolic Process Histone Deacetylase Complex Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Nuclear Receptor Activity Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Chromatin Binding Hormone-mediated Signaling Pathway DNA-binding Transcription Factor Activity Negative Regulation Of Macromolecule Metabolic Process Transcription By RNA Polymerase II Sequence-specific Double-stranded DNA Binding DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Sin3-type Complex Chromatin Organization Retinoic Acid Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Metabolic Process Retinoic Acid-responsive Element Binding Nucleic Acid Metabolic Process	MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity RISC Complex Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of MRNA Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Macromolecule Metabolic Process Positive Regulation Of MRNA Metabolic Process RNA Binding Extracellular Vesicle Positive Regulation Of MRNA Catabolic Process Regulation Of Metabolic Process MRNA Destabilization RNA Destabilization Negative Regulation Of Translation Nucleic Acid Binding Regulation Of Translation Regulation Of RNA Stability Regulation Of MRNA Stability Regulation Of RNA Splicing MRNA Binding Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Regulation Of Primary Metabolic Process Negative Regulation Of Cytokine Production Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway MRNA Processing Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Protein Metabolic Process RNA Processing Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Angiogenesis Regulation Of Vasculature Development
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