SMYD5 and H1-1

Number of citations of the paper that reports this interaction (PubMedID 36897778)
69

Data Source:
BioGRID (enzymatic study)

		SMYD5	H1-1
Description		SMYD family member 5	H1.1 linker histone, cluster member
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Chromatin Nucleosome Euchromatin Nucleus Nucleoplasm Chromosome Cell Surface Vesicle
	Molecular Function	Protein Binding Methyltransferase Activity Zinc Ion Binding Protein-lysine N-methyltransferase Activity Transferase Activity Histone H4K20 Methyltransferase Activity Metal Ion Binding Histone H4K20 Trimethyltransferase Activity Histone H3K36 Trimethyltransferase Activity	DNA Binding Double-stranded DNA Binding Protein Binding Heparin Binding Structural Constituent Of Chromatin Chromatin DNA Binding Nucleosomal DNA Binding
	Biological Process	Cytoplasmic Translation Methylation Negative Regulation Of Gene Expression, Epigenetic Transposable Element Silencing By Heterochromatin Formation Positive Regulation Of Cytoplasmic Translational Elongation Regulation Of Stem Cell Division Regulation Of Stem Cell Differentiation	Nucleosome Assembly Spermatogenesis Chromosome Condensation Negative Regulation Of DNA Recombination Positive Regulation Of Receptor-mediated Endocytosis
Pathways			Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs
Diseases
GWAS
Interacting Genes		6 interacting genes: H1-1 H2BC3 H3C1 H4C1 ZNF417 ZNF587	54 interacting genes: AEBP2 APP CCNA1 CCNA2 CCNB1 CCND2 CCNE1 CDK1 CDK11B CDK2 CDK4 CDK5 CDK6 CDK7 CDKN1B CRP CTCFL EED EHMT2 EP300 EZH2 GADD45A GZMA IRAK4 KAT2B LIMK1 LIMK2 LOX NAP1L1 NAP1L4 NASP NSD3 PAK4 PARP1 PARP3 PELP1 PRDM1 PRKCA PRKCB PRKCD PRKCE PRKCZ PRKDC PTMA RBBP4 RPS6KA5 SET SMYD5 SNCA SUZ12 TAF1 TERF1 TERF2IP TLK1
Entrez ID		10322	3024
HPRD ID		18080	00820
Ensembl ID		ENSG00000135632	ENSG00000124610
Uniprot IDs		Q6GMV2	Q02539
PDB IDs			9J8O
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Chromatin Nucleosome Nucleosome Assembly Nucleosome Organization Protein-DNA Complex Assembly DNA Binding Chromatin Remodeling Chromosome Chromatin Organization Protein Heterodimerization Activity Chromosome Organization L-cysteine-S-conjugate N-acetyltransferase Activity Protein-containing Complex Assembly Peptidyl-lysine N6-acetylation Telomere Organization Protein-containing Complex Organization Chromosome, Telomeric Region L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Internal Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Peptidyl-lysine Acetylation N-acetyltransferase Activity CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Megakaryocyte Differentiation	Chromatin Organization Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Chromatin Remodeling Nucleus Protein Kinase Activity Kinase Activity Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of Nucleobase-containing Compound Metabolic Process Transferase Activity G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Protein Phosphorylation Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Phosphorylation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Mitotic Cell Cycle Phase Transition Regulation Of Metabolic Process Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Cell Cycle Cell Cycle Phase Transition Regulation Of Cell Cycle Process Negative Regulation Of Metabolic Process Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Cellular Response To Stress Cellular Response To Oxygen-containing Compound Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone Binding Positive Regulation Of Macromolecule Metabolic Process Protein Modification Process Response To Stress Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Negative Regulation Of RNA Metabolic Process ESC/E(Z) Complex Regulation Of Cell Cycle Phase Transition Cell Division Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Localization To Chromosome
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