SMYD5 and ZNF587

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SMYD5	ZNF587
Description		SMYD family member 5	zinc finger protein 587
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Nucleus
	Molecular Function	Protein Binding Methyltransferase Activity Zinc Ion Binding Protein-lysine N-methyltransferase Activity Transferase Activity Histone H4K20 Methyltransferase Activity Metal Ion Binding Histone H4K20 Trimethyltransferase Activity Histone H3K36 Trimethyltransferase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Cytoplasmic Translation Methylation Negative Regulation Of Gene Expression, Epigenetic Transposable Element Silencing By Heterochromatin Formation Positive Regulation Of Cytoplasmic Translational Elongation Regulation Of Stem Cell Division Regulation Of Stem Cell Differentiation	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II
Pathways			Generic Transcription Pathway
Drugs
Diseases
GWAS			Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444)
Interacting Genes		6 interacting genes: H1-1 H2BC3 H3C1 H4C1 ZNF417 ZNF587	130 interacting genes: ADAMTSL4 AQP6 ASB15 ASB6 AXIN2 BEGAIN C17orf50 CARD10 CARD9 CCDC125 CCDC136 CCDC85B CEP44 CEP70 CHRDL2 CSRNP1 CYSRT1 DEF8 DHX57 EFEMP2 FCHSD2 FHL3 FHL5 FSD2 FST GOLGA2 GOLGA6L9 GOPC GSC2 HMBOX1 HOOK2 HOXA1 HSF2BP IGFBP6 IKBKG IKZF1 IKZF3 INSC ISY1-RAB43 KATNBL1 KCTD7 KPRP KRT31 KRT38 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP5-7 KRTAP5-9 LDOC1 LHX3 LIMS1 LMO3 LRP2BP LZTS1 MCCD1 MDFI MEOX2 MID2 MKRN3 MTUS2 MYF5 NBPF19 NDUFB7 NEK6 NKAPL NOTCH2NLA NR1D2 PBX2 PDE4DIP PLSCR1 PNMA2 PPARA PRDM14 PRICKLE4 PRPF31 RORB RUNDC3A SMAD9 SMYD5 SOX13 SPRED1 SPRY2 SPRY3 SSX2IP STX11 TBC1D26 TCF4 TENM4 TFIP11 TMCC2 TNS2 TRAF1 TRIB3 TRIM23 TRIM27 TRIM36 TRIM37 TRIM41 TRIM54 TSC1 TSGA10 TXK VPS52 VWC2 ZBTB43 ZBTB8A ZGPAT ZIM2 ZKSCAN8 ZNF286A ZNF330 ZNF417 ZNF547 ZNF774 ZNF829 ZNF837 ZRANB1
Entrez ID		10322	84914
HPRD ID		18080	15864
Ensembl ID		ENSG00000135632	ENSG00000198466
Uniprot IDs		Q6GMV2	Q96SQ5
PDB IDs
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Chromatin Nucleosome Nucleosome Assembly Nucleosome Organization Protein-DNA Complex Assembly DNA Binding Chromatin Remodeling Chromosome Chromatin Organization Protein Heterodimerization Activity Chromosome Organization L-cysteine-S-conjugate N-acetyltransferase Activity Protein-containing Complex Assembly Peptidyl-lysine N6-acetylation Telomere Organization Protein-containing Complex Organization Chromosome, Telomeric Region L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Internal Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Peptidyl-lysine Acetylation N-acetyltransferase Activity CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Megakaryocyte Differentiation	Intermediate Filament Keratin Filament Zinc Ion Binding Protein Binding Identical Protein Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Sequence-specific DNA Binding Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity
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