CDK2AP2 and MBTPS1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		CDK2AP2	MBTPS1
Description		cyclin dependent kinase 2 associated protein 2	membrane bound transcription factor peptidase, site 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Microtubule NuRD Complex	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Golgi Apparatus Golgi Stack Membrane
	Molecular Function	Protein Binding	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Regulation Of Microtubule Cytoskeleton Organization Regulation Of Stem Cell Division Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Proteolysis Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Lipid Metabolic Process Lysosome Organization Mitotic G2 DNA Damage Checkpoint Signaling Steroid Metabolic Process Cholesterol Metabolic Process Protein Processing Endoplasmic Reticulum Unfolded Protein Response Membrane Protein Intracellular Domain Proteolysis Response To Endoplasmic Reticulum Stress ATF6-mediated Unfolded Protein Response Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process Protein Maturation Regulation Of Vesicle-mediated Transport
Pathways			Regulation of cholesterol biosynthesis by SREBP (SREBF) ATF6 (ATF6-alpha) activates chaperones Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) ATF6B (ATF6-beta) activates chaperones CREB3 factors activate genes CREB3 factors activate genes Post-translational protein phosphorylation Assembly of active LPL and LIPC lipase complexes
Drugs
Diseases
GWAS			Iris color (a* coordinate) ( 30895295) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872)
Interacting Genes		17 interacting genes: A2M APP CDK2AP1 DBN1 EED EEF1G HSF4 IKZF1 MBTPS1 MRFAP1L1 PYCR1 RCC1 RPLP1 TRA2A WARS1 YIF1A ZBTB48	10 interacting genes: ATF6B BDNF BIRC3 C11orf58 CANX CDK2AP2 FAM200C SPHK1 TNFRSF14 TNFSF11
Entrez ID		10263	8720
HPRD ID		13242	04522
Ensembl ID		ENSG00000167797	ENSG00000140943
Uniprot IDs		O75956 Q6IAV4	Q14703
PDB IDs		2M1L	8UW8 8UWC
Enriched GO Terms of Interacting Partners?			Tumor Necrosis Factor-mediated Signaling Pathway
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