CDK2AP2 and PYCR1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		CDK2AP2	PYCR1
Description		cyclin dependent kinase 2 associated protein 2	pyrroline-5-carboxylate reductase 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Microtubule NuRD Complex	Mitochondrion Mitochondrial Matrix
	Molecular Function	Protein Binding	Pyrroline-5-carboxylate Reductase Activity Protein Binding Oxidoreductase Activity Identical Protein Binding
	Biological Process	Regulation Of Microtubule Cytoskeleton Organization Regulation Of Stem Cell Division Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Amino Acid Biosynthetic Process Cellular Response To Oxidative Stress Regulation Of Mitochondrial Membrane Potential L-proline Biosynthetic Process Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Pathways			Glutamate and glutamine metabolism
Drugs			NADH Proline
Diseases			Geroderma osteodysplasticum
GWAS
Interacting Genes		17 interacting genes: A2M APP CDK2AP1 DBN1 EED EEF1G HSF4 IKZF1 MBTPS1 MRFAP1L1 PYCR1 RCC1 RPLP1 TRA2A WARS1 YIF1A ZBTB48	7 interacting genes: BNIPL CDK2AP2 FXR1 HNRNPD NUDT21 SIRT3 TNPO2
Entrez ID		10263	5831
HPRD ID		13242	01528
Ensembl ID		ENSG00000167797	ENSG00000183010
Uniprot IDs		O75956 Q6IAV4	E2QRB3 J3QL32 P32322 Q8TBX0
PDB IDs		2M1L	2GER 2GR9 2GRA 2IZZ 5UAT 5UAU 5UAV 5UAW 5UAX 6XOZ 6XP0 6XP1 6XP2 6XP3 8DKG 8TCU 8TCV 8TCW 8TCX 8TCY 8TCZ 8TD0 8TD1 8TD2 8TD3 8TD4 8TD5 8TD6 8TD7 8TD8 8TD9 8TDB 8TDC 8TDD 8VRE
Enriched GO Terms of Interacting Partners?			MRNA 3'-UTR AU-rich Region Binding Negative Regulation Of MRNA Catabolic Process Hepatocyte Dedifferentiation Cellular Response To Putrescine MRNA Binding Positive Regulation Of Pro-B Cell Differentiation Positive Regulation Of Catalase Activity Positive Regulation Of Superoxide Dismutase Activity Positive Regulation Of MRNA Catabolic Process MRNA Destabilization RNA Destabilization Negative Regulation Of RNA Catabolic Process Regulation Of Circadian Rhythm Negative Regulation Of MRNA Metabolic Process Circadian Regulation Of Translation Regulation Of Superoxide Dismutase Activity NAD-dependent Protein Lysine Delactylase Activity Histone Deacetylase Binding Nucleus Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Lymphoid Progenitor Cell Differentiation Peptidyl-lysine Deacetylation Positive Regulation Of Oxidative Phosphorylation Post-transcriptional Regulation Of Gene Expression Positive Regulation Of MRNA Metabolic Process MRNA Alternative Polyadenylation Positive Regulation Of Translation Positive Regulation Of Telomere Capping MCRD-mediated MRNA Stability Complex RNA Strand Annealing Activity Nuclear Pore Localization Histone Deacetylase Activity, NAD-dependent Regulation Of Growth Rate Response To Rapamycin Regulation Of MRNA Stability Cell Dedifferentiation Intracellular Membraneless Organelle MRNA Cleavage Factor Complex Positive Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Ceramide Biosynthetic Process NAD-dependent Protein Lysine Deacetylase Activity Regulation Of RNA Stability Regulation Of Pro-B Cell Differentiation Response To Sodium Phosphate Minor Groove Of Adenine-thymine-rich DNA Binding Positive Regulation Of Long-term Neuronal Synaptic Plasticity Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway Nuclear Pore Complex Assembly Paraspeckles CRD-mediated MRNA Stabilization
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