Wiki-Pi
About
Search
People
Updates
Search
TNIP1 and CDKN1A
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
TNIP1
CDKN1A
Description
TNFAIP3 interacting protein 1
cyclin dependent kinase inhibitor 1A
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Cyclin-dependent Protein Kinase Holoenzyme Complex
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Nuclear Body
Protein-containing Complex
PCNA-p21 Complex
Molecular Function
Protein Binding
Identical Protein Binding
Mitogen-activated Protein Kinase Binding
Protein Kinase Inhibitor Activity
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Protein Binding
Zinc Ion Binding
Protein Kinase Binding
Cyclin Binding
Ubiquitin Protein Ligase Binding
Protein-containing Complex Binding
Metal Ion Binding
Protein Serine/threonine Kinase Binding
Protein Sequestering Activity
Molecular Function Activator Activity
Molecular Function Inhibitor Activity
Biological Process
MyD88-dependent Toll-like Receptor Signaling Pathway
Regulation Of Transcription By RNA Polymerase II
Translation
Defense Response
Inflammatory Response
Leukocyte Cell-cell Adhesion
Glycoprotein Biosynthetic Process
Positive Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Viral Genome Replication
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Inflammatory Response
Negative Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Lipopolysaccharide
Regulation Of Primary Metabolic Process
Positive Regulation Of Protein Deubiquitination
G1/S Transition Of Mitotic Cell Cycle
In Utero Embryonic Development
Protein Import Into Nucleus
DNA Damage Response
Mitotic G2 DNA Damage Checkpoint Signaling
Ras Protein Signal Transduction
Regulation Of Mitotic Cell Cycle
Heart Development
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Epidermis Development
Response To UV
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Gene Expression
Keratinocyte Differentiation
Negative Regulation Of Cell Growth
DNA Damage Response, Signal Transduction By P53 Class Mediator
Positive Regulation Of B Cell Proliferation
Mitotic G1 DNA Damage Checkpoint Signaling
Cellular Response To Amino Acid Starvation
Wound Healing
Tissue Regeneration
Signal Transduction In Response To DNA Damage
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Positive Regulation Of Programmed Cell Death
Keratinocyte Proliferation
Positive Regulation Of DNA Replication
Positive Regulation Of Protein Kinase Activity
Negative Regulation Of Growth
Fibroblast Proliferation
Positive Regulation Of Fibroblast Proliferation
Import Into Nucleus
Regulation Of Cell Cycle
Cellular Response To Cell-matrix Adhesion
Cellular Response To Ionizing Radiation
Cellular Response To Gamma Radiation
Cellular Response To UV-B
Signal Transduction By P53 Class Mediator
Cellular Senescence
Replicative Senescence
Stress-induced Premature Senescence
Oncogene-induced Cell Senescence
Intrinsic Apoptotic Signaling Pathway
Regulation Of Cell Cycle G1/S Phase Transition
Negative Regulation Of Cyclin-dependent Protein Kinase Activity
Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Negative Regulation Of Cardiac Muscle Tissue Regeneration
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of DNA Biosynthetic Process
Negative Regulation Of DNA Biosynthetic Process
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
Ovarian tumor domain proteases
SCF(Skp2)-mediated degradation of p27/p21
AKT phosphorylates targets in the cytosol
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
Constitutive Signaling by AKT1 E17K in Cancer
Interleukin-4 and Interleukin-13 signaling
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry
Transcriptional activation of cell cycle inhibitor p21
The role of GTSE1 in G2/M progression after G2 checkpoint
TFAP2 (AP-2) family regulates transcription of cell cycle factors
Transcriptional regulation by RUNX2
RUNX3 regulates CDKN1A transcription
Neddylation
Transcriptional regulation of granulopoiesis
FOXO-mediated transcription of cell cycle genes
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
STAT5 activation downstream of FLT3 ITD mutants
Signaling by FLT3 fusion proteins
Signaling by ALK fusions and activated point mutants
KEAP1-NFE2L2 pathway
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
Drugs
Valproic acid
Arsenic trioxide
Diseases
Cervical cancer
GWAS
Amyotrophic lateral sclerosis (
29566793
)
Autoimmune traits (pleiotropy) (
30572963
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Crohn's disease (
28067908
)
Cutaneous psoriasis (
26626624
)
Eosinophil count (
27863252
32888494
)
Eosinophil percentage of granulocytes (
27863252
)
Eosinophil percentage of white cells (
32888494
27863252
)
Inflammatory bowel disease (
23128233
28067908
)
Inflammatory skin disease (
25574825
)
LDL cholesterol levels in HIV infection (
33109212
)
Lymphocyte count (
32888494
)
Lymphocyte percentage of white cells (
32888494
)
Myasthenia gravis (
23055271
)
Neutrophil percentage of granulocytes (
27863252
)
Psoriasis (
25903422
25854761
25574825
23143594
19169254
)
Psoriasis vulgaris (
26626624
29031612
)
Psoriatic arthritis (
26626624
)
Rheumatoid arthritis (
30572963
)
Rheumatoid arthritis (ACPA-positive) (
23143596
)
Serum alkaline phosphatase levels (
33547301
)
Sjögren's syndrome (
24097067
)
Sum eosinophil basophil counts (
27863252
)
Systemic lupus erythematosus (
28714469
27399966
26606652
26502338
23273568
19838195
33272962
19838193
)
Systemic lupus erythematosus and Systemic sclerosis (
23740937
)
Systemic sclerosis (
29293537
30572963
31672989
21750679
)
Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) (
30573655
)
Abdominal aortic aneurysm (
32981348
)
Alanine aminotransferase levels (
34315874
33547301
)
Aspartate aminotransferase levels (
34315874
33547301
)
Atrial fibrillation (
30061737
29892015
)
Colorectal cancer (
30529582
31826910
22634755
)
Colorectal cancer or advanced adenoma (
30510241
)
Coronary artery disease (
29212778
)
Dilated cardiomyopathy (MTAG) (
33495596
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Electrocardiographic conduction measures (
23463857
)
Electrocardiographic traits (
20062063
)
Electrocardiographic traits (multivariate) (
32602732
)
Glaucoma (primary open-angle) (
29891935
)
Heart failure (
31919418
)
Hypertrophic cardiomyopathy (
33495597
33495596
)
Hypertrophic cardiomyopathy (MTAG) (
33495596
)
Hypertrophic cardiomyopathy (sarcomere negative) (
33495597
)
JT interval (
29874175
)
Left ventricle wall thickness (
33495596
)
Left ventricular fractional shortening (
28394258
)
Left ventricular global circumferential strain (
33495596
)
Left ventricular global radial strain (
33495596
)
Left ventricular mass to end-diastolic volume ratio (
33495596
)
PR interval (
32439900
)
Pulse pressure (
30224653
30578418
)
QRS complex (Cornell) (
27659466
)
QRS duration (
31251759
31217584
30679814
27659466
27577874
25035420
21076409
)
Triglyceride levels (
32203549
)
Triglycerides (
27036123
)
Interacting Genes
88 interacting genes:
ABHD17A
ADH6
AP1M1
BYSL
C8orf33
CCDC112
CCDC121
CCNG1
CDC23
CDC37
CDIP1
CDKN1A
CFAP53
CYSRT1
DAZAP2
DPPA4
EFEMP1
EHHADH
ELOA
FAM161A
FAM168A
GABARAP
GABARAPL1
GABARAPL2
GIT2
GTF2B
GTF2H1
IKBKG
KIFC3
KRTAP19-3
KRTAP19-5
KRTAP19-7
KRTAP6-1
KRTAP6-2
KRTAP6-3
KRTAP8-1
LENG8
LITAF
MAGEB18
MAGEH1
MAP1LC3A
MAP1LC3B
MAP1LC3C
MAP3K1
MAPK1
MAPK10
MCM10
MCRS1
MOB1B
MOB3C
MORF4L1
MORF4L2
NIFK
NME7
NOD2
PIBF1
PNKP
RABAC1
RALBP1
RARA
RARG
RBFOX1
RNF11
RNF8
RPL5
S100B
SELPLG
SHTN1
SNIP1
SPATA2
SUMO2
SYT6
TBK1
TCEA2
TCEANC
TCEANC2
TNFAIP3
TNIP3
TTC39A
TTF2
TXLNA
TYRO3
UBC
VPS33B
WTAP
ZBTB25
ZMAT2
ZNHIT1
207 interacting genes:
A1BG
A2M
ABL1
ACTB
ACTL6B
ADAMTS10
AKT1
AKT2
ALAS1
ANGPT2
APLP1
APP
ATP5F1B
ATP6V1A
ATXN3
BAD
BAG6
BCCIP
CASP3
CCDC85B
CCN3
CCNA1
CCNA2
CCNB1
CCNB2
CCND1
CCND2
CCND3
CCNE1
CCNE2
CCT7
CDC45
CDC5L
CDC6
CDC7
CDK1
CDK14
CDK2
CDK3
CDK4
CDK6
CEBPA
CELF3
CENPB
CHEK2
CHGB
CIZ1
CLEC3B
COL4A5
COPS6
CPNE2
CPNE6
CSAD
CSNK2A1
CSNK2B
CTSB
CZIB
DAPK3
DCAF11
DDAH2
DEAF1
DOCK7
DTL
DYNC1I1
EEF1A1
ESR1
EXT2
F13A1
FAF1
FBN3
FGB
FHL3
FLAD1
FNDC11
GADD45A
GADD45B
GADD45G
GAPDH
GCKR
GDF9
GET4
GMNN
GNB2
GNB5
GOLGA2
H1-5
HADHB
HDAC1
HDAC11
HDAC2
HDAC4
HDAC6
HERC5
HMGXB3
HNRNPK
HOOK2
HOXD8
HPD
IKBKG
IKZF3
INCA1
ING5
INPP5K
KIFC3
KLHL23
KMT2B
KRT31
KRTAP3-1
LATS2
LRIF1
LRP2BP
LRR1
LZTS2
MAP3K5
MAPK8
MCM10
MED31
MEOX2
MSH2
MTUS2
NFYA
NGFR
NKD2
NMRK2
NPRL2
NR1H2
NRBP1
NSUN2
OTUB1
PARP1
PCNA
PDE4DIP
PDHB
PIM1
POLD2
PPM1D
PRKACA
PRKAR1B
PRKN
PSMA3
PSMC2
QARS1
RAB1A
RACK1
RAI1
RANBP9
RB1
RBBP4
RBM48
REL
RNF144B
RPL18
RPL35
RPS2
RRM2B
S100A8
SCML2
SDF4
SET
SETDB1
SHISA6
SIPA1
SKP1
SLC25A11
SP110
SPRED1
STAT3
STAT5B
STUB1
SUMO3
TAF5L
TCF4
TEX11
TFIP11
TK1
TLE1
TMSB4X
TNIP1
TNIP2
TNKS
TRAF1
TRIM21
TRIM3
TRIM54
TRIM71
TRMT2A
TSG101
TTLL5
TUBA1A
TUBB2B
TUBB3
TXN
TXNDC11
UBE2D1
UNC119
USHBP1
USP4
VIM
VPS51
WDR73
WIZ
XRCC6
YWHAQ
ZBTB16
ZBTB48
ZNF135
ZNF431
Entrez ID
10318
1026
HPRD ID
09216
00298
Ensembl ID
ENSG00000145901
ENSG00000124762
Uniprot IDs
A0A0A0MRZ4
A8K4N4
B7Z8K2
Q15025
P38936
PDB IDs
7EAL
7EAO
7EB9
8YFK
8YFL
8YFM
8YFN
9D34
1AXC
2ZVV
2ZVW
4RJF
5E0U
6CBI
6CEJ
6CIV
6CIX
6P8H
7KQ0
7KQ1
8GJF
Enriched GO Terms of Interacting Partners
?
Cellular Response To Nitrogen Starvation
Phosphatidylethanolamine Binding
Ubiquitin Protein Ligase Binding
Autophagosome Maturation
Protein Binding
Autophagosome Membrane
Mitophagy
Autophagy Of Mitochondrion
Autophagosome
Cellular Response To Starvation
Cellular Response To Nutrient Levels
Autophagosome Assembly
Protein-containing Complex Disassembly
Autophagosome Organization
Response To Starvation
Macroautophagy
Intermediate Filament
Cytoplasmic Side Of Late Endosome Membrane
Response To Nutrient Levels
Phospholipid Binding
Nucleoplasm
Organelle Assembly
Positive Regulation Of DNA Repair
GABA Receptor Binding
Regulation Of Protein Modification Process
Positive Regulation Of DNA Metabolic Process
Cellular Response To Stress
Nucleic Acid Metabolic Process
Trachea Cartilage Development
Autophagy
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Face Development
Glandular Epithelial Cell Development
Regulation Of Canonical NF-kappaB Signal Transduction
Vacuole Organization
DNA-templated Transcription
Intestinal Stem Cell Homeostasis
Regulation Of Cellular Response To Stress
Cytosol
Protein Modification Process
Negative Regulation Of Cartilage Development
Nucleus
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
DNA Damage Response
Regulation Of Protein Phosphorylation
Ciliary Basal Body
Beta-tubulin Binding
Nucleus
Nucleoplasm
Regulation Of Primary Metabolic Process
Cytoplasm
G1/S Transition Of Mitotic Cell Cycle
Cell Cycle G1/S Phase Transition
Regulation Of Cell Cycle
Cyclin-dependent Protein Kinase Holoenzyme Complex
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Regulation Of Protein Metabolic Process
Positive Regulation Of Metabolic Process
Cyclin Binding
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Mitotic Cell Cycle
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Apoptotic Process
Cytosol
Regulation Of Programmed Cell Death
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Macromolecule Metabolic Process
Regulation Of Cell Cycle Phase Transition
Cell Division
Positive Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Cell Cycle Phase Transition
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Mitotic Cell Cycle
Negative Regulation Of Signal Transduction
Cellular Response To Stress
Negative Regulation Of Intracellular Signal Transduction
Protein Binding
Regulation Of Macromolecule Biosynthetic Process
Protein Kinase Binding
Regulation Of DNA-templated Transcription
Negative Regulation Of Cell Cycle
Regulation Of RNA Biosynthetic Process
Regulation Of Gene Expression
DNA Damage Response
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Cell Cycle
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Cyclin-dependent Protein Serine/threonine Kinase Activity
Regulation Of Fibroblast Proliferation
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?