TNIP1 and MORF4L1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		TNIP1	MORF4L1
Description		TNFAIP3 interacting protein 1	mortality factor 4 like 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleosome Nucleus Nucleoplasm Nuclear Speck NuA4 Histone Acetyltransferase Complex Sin3-type Complex
	Molecular Function	Protein Binding Identical Protein Binding Mitogen-activated Protein Kinase Binding	Chromatin Binding Protein Binding
	Biological Process	MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Transcription By RNA Polymerase II Translation Defense Response Inflammatory Response Leukocyte Cell-cell Adhesion Glycoprotein Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Viral Genome Replication Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Inflammatory Response Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Regulation Of Primary Metabolic Process Positive Regulation Of Protein Deubiquitination	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination Chromatin Organization Regulation Of DNA-templated Transcription DNA Damage Response Cell Population Proliferation Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Fibroblast Proliferation Regulation Of Cell Cycle Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair
Pathways		Ovarian tumor domain proteases	HATs acetylate histones
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis ( 29566793) Autoimmune traits (pleiotropy) ( 30572963) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Cutaneous psoriasis ( 26626624) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Inflammatory bowel disease ( 23128233 28067908) Inflammatory skin disease ( 25574825) LDL cholesterol levels in HIV infection ( 33109212) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Myasthenia gravis ( 23055271) Neutrophil percentage of granulocytes ( 27863252) Psoriasis ( 25903422 25854761 25574825 23143594 19169254) Psoriasis vulgaris ( 26626624 29031612) Psoriatic arthritis ( 26626624) Rheumatoid arthritis ( 30572963) Rheumatoid arthritis (ACPA-positive) ( 23143596) Serum alkaline phosphatase levels ( 33547301) Sjögren's syndrome ( 24097067) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 28714469 27399966 26606652 26502338 23273568 19838195 33272962 19838193) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 29293537 30572963 31672989 21750679) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655)	Coronary artery disease ( 32469254 33020668) Coronary heart disease ( 21378988) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730 31577861) Lung cancer in ever smokers ( 28604730) Myocardial infarction ( 33532862) Pulse pressure ( 27841878 30578418) Refractive error ( 32231278) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		88 interacting genes: ABHD17A ADH6 AP1M1 BYSL C8orf33 CCDC112 CCDC121 CCNG1 CDC23 CDC37 CDIP1 CDKN1A CFAP53 CYSRT1 DAZAP2 DPPA4 EFEMP1 EHHADH ELOA FAM161A FAM168A GABARAP GABARAPL1 GABARAPL2 GIT2 GTF2B GTF2H1 IKBKG KIFC3 KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP8-1 LENG8 LITAF MAGEB18 MAGEH1 MAP1LC3A MAP1LC3B MAP1LC3C MAP3K1 MAPK1 MAPK10 MCM10 MCRS1 MOB1B MOB3C MORF4L1 MORF4L2 NIFK NME7 NOD2 PIBF1 PNKP RABAC1 RALBP1 RARA RARG RBFOX1 RNF11 RNF8 RPL5 S100B SELPLG SHTN1 SNIP1 SPATA2 SUMO2 SYT6 TBK1 TCEA2 TCEANC TCEANC2 TNFAIP3 TNIP3 TTC39A TTF2 TXLNA TYRO3 UBC VPS33B WTAP ZBTB25 ZMAT2 ZNHIT1	83 interacting genes: APP ARID3A ARRDC3 BEND7 BEX5 BTG3 CALM1 CAMK2B CEBPA CEP57L1 CWC27 DMAP1 DRAP1 DSCR9 DYSF EP300 FAM13C FAM9B FBXO16 FHL3 FXR2 GMCL1 GOLGA2 GOLGA6A GSC2 H3-4 H3C1 HINFP HMBOX1 IKZF1 KPNA2 L3MBTL3 LHX2 LMNA LZTS2 MEOX1 MEOX2 MRFAP1 MRFAP1L1 MRGBP MRPL12 MSL1 NAB2 NAV2 NECAB1 NKD1 NMI PBXIP1 PCM1 PHF12 PIBF1 PICK1 PLEKHA3 PSMC1 RACGAP1 RB1 RCBTB2 REL SH3GLB2 SYN3 TEPSIN TEX11 TFCP2 THAP1 TLE5 TNIP1 TNNT1 TNNT2 TRIM41 TTC3 TULP3 UBP1 USO1 VPS26A ZBTB10 ZBTB26 ZBTB43 ZBTB8B ZBTB9 ZC3H7A ZNF276 ZNF438 ZNF449
Entrez ID		10318	10933
HPRD ID		09216	09532
Ensembl ID		ENSG00000145901	ENSG00000185787
Uniprot IDs		A0A0A0MRZ4 A8K4N4 B7Z8K2 Q15025	Q9UBU8
PDB IDs		7EAL 7EAO 7EB9 8YFK 8YFL 8YFM 8YFN 9D34	2AQL 2EFI 2F5J 2F5K 2LKM 2N1D 6AGO 6INE 7S4A 8BPA 8C60
Enriched GO Terms of Interacting Partners?		Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Ubiquitin Protein Ligase Binding Autophagosome Maturation Protein Binding Autophagosome Membrane Mitophagy Autophagy Of Mitochondrion Autophagosome Cellular Response To Starvation Cellular Response To Nutrient Levels Autophagosome Assembly Protein-containing Complex Disassembly Autophagosome Organization Response To Starvation Macroautophagy Intermediate Filament Cytoplasmic Side Of Late Endosome Membrane Response To Nutrient Levels Phospholipid Binding Nucleoplasm Organelle Assembly Positive Regulation Of DNA Repair GABA Receptor Binding Regulation Of Protein Modification Process Positive Regulation Of DNA Metabolic Process Cellular Response To Stress Nucleic Acid Metabolic Process Trachea Cartilage Development Autophagy Negative Regulation Of Canonical NF-kappaB Signal Transduction Face Development Glandular Epithelial Cell Development Regulation Of Canonical NF-kappaB Signal Transduction Vacuole Organization DNA-templated Transcription Intestinal Stem Cell Homeostasis Regulation Of Cellular Response To Stress Cytosol Protein Modification Process Negative Regulation Of Cartilage Development Nucleus Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity DNA Damage Response Regulation Of Protein Phosphorylation Ciliary Basal Body Beta-tubulin Binding	Identical Protein Binding Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleoplasm Nucleus Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Spermatogonial Cell Division Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process Rb-E2F Complex Somite Specification Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Transcription Coregulator Activity Negative Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific Double-stranded DNA Binding Transcription Corepressor Activity Troponin Complex Chromatin Organization Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Importin-alpha Family Protein Binding Regulation Of Protein Localization To Nucleus Positive Regulation Of Metabolic Process Regulation Of Skeletal Muscle Adaptation DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
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