TNIP1 and MOB1B

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		TNIP1	MOB1B
Description		TNFAIP3 interacting protein 1	MOB kinase activator 1B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Protein Binding Identical Protein Binding Mitogen-activated Protein Kinase Binding	Protein Binding Kinase Activator Activity Kinase Binding Protein Kinase Activator Activity Protein Serine/threonine Kinase Activator Activity Metal Ion Binding
	Biological Process	MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Transcription By RNA Polymerase II Translation Defense Response Inflammatory Response Leukocyte Cell-cell Adhesion Glycoprotein Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Viral Genome Replication Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Inflammatory Response Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Regulation Of Primary Metabolic Process Positive Regulation Of Protein Deubiquitination	Regulation Of Protein Autophosphorylation Hippo Signaling
Pathways		Ovarian tumor domain proteases	Signaling by Hippo
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis ( 29566793) Autoimmune traits (pleiotropy) ( 30572963) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Cutaneous psoriasis ( 26626624) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Inflammatory bowel disease ( 23128233 28067908) Inflammatory skin disease ( 25574825) LDL cholesterol levels in HIV infection ( 33109212) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Myasthenia gravis ( 23055271) Neutrophil percentage of granulocytes ( 27863252) Psoriasis ( 25903422 25854761 25574825 23143594 19169254) Psoriasis vulgaris ( 26626624 29031612) Psoriatic arthritis ( 26626624) Rheumatoid arthritis ( 30572963) Rheumatoid arthritis (ACPA-positive) ( 23143596) Serum alkaline phosphatase levels ( 33547301) Sjögren's syndrome ( 24097067) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 28714469 27399966 26606652 26502338 23273568 19838195 33272962 19838193) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 29293537 30572963 31672989 21750679) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655)	Femur bone mineral density x serum urate levels interaction ( 34046847) Leukocyte telomere length ( 32109421) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Type 2 diabetes ( 30718926 32499647)
Interacting Genes		88 interacting genes: ABHD17A ADH6 AP1M1 BYSL C8orf33 CCDC112 CCDC121 CCNG1 CDC23 CDC37 CDIP1 CDKN1A CFAP53 CYSRT1 DAZAP2 DPPA4 EFEMP1 EHHADH ELOA FAM161A FAM168A GABARAP GABARAPL1 GABARAPL2 GIT2 GTF2B GTF2H1 IKBKG KIFC3 KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP8-1 LENG8 LITAF MAGEB18 MAGEH1 MAP1LC3A MAP1LC3B MAP1LC3C MAP3K1 MAPK1 MAPK10 MCM10 MCRS1 MOB1B MOB3C MORF4L1 MORF4L2 NIFK NME7 NOD2 PIBF1 PNKP RABAC1 RALBP1 RARA RARG RBFOX1 RNF11 RNF8 RPL5 S100B SELPLG SHTN1 SNIP1 SPATA2 SUMO2 SYT6 TBK1 TCEA2 TCEANC TCEANC2 TNFAIP3 TNIP3 TTC39A TTF2 TXLNA TYRO3 UBC VPS33B WTAP ZBTB25 ZMAT2 ZNHIT1	4 interacting genes: APP NT5C2 TNIP1 WASHC3
Entrez ID		10318	92597
HPRD ID		09216	17582
Ensembl ID		ENSG00000145901	ENSG00000173542
Uniprot IDs		A0A0A0MRZ4 A8K4N4 B7Z8K2 Q15025	B3KSH6 Q7L9L4
PDB IDs		7EAL 7EAO 7EB9 8YFK 8YFL 8YFM 8YFN 9D34
Enriched GO Terms of Interacting Partners?		Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Ubiquitin Protein Ligase Binding Autophagosome Maturation Protein Binding Autophagosome Membrane Mitophagy Autophagy Of Mitochondrion Autophagosome Cellular Response To Starvation Cellular Response To Nutrient Levels Autophagosome Assembly Protein-containing Complex Disassembly Autophagosome Organization Response To Starvation Macroautophagy Intermediate Filament Cytoplasmic Side Of Late Endosome Membrane Response To Nutrient Levels Phospholipid Binding Nucleoplasm Organelle Assembly Positive Regulation Of DNA Repair GABA Receptor Binding Regulation Of Protein Modification Process Positive Regulation Of DNA Metabolic Process Cellular Response To Stress Nucleic Acid Metabolic Process Trachea Cartilage Development Autophagy Negative Regulation Of Canonical NF-kappaB Signal Transduction Face Development Glandular Epithelial Cell Development Regulation Of Canonical NF-kappaB Signal Transduction Vacuole Organization DNA-templated Transcription Intestinal Stem Cell Homeostasis Regulation Of Cellular Response To Stress Cytosol Protein Modification Process Negative Regulation Of Cartilage Development Nucleus Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity DNA Damage Response Regulation Of Protein Phosphorylation Ciliary Basal Body Beta-tubulin Binding	Negative Regulation Of Blood Circulation Regulation Of Defense Response Negative Regulation Of MiRNA Transcription Positive Regulation Of Inflammatory Response Regulation Of Amyloid-beta Clearance Astrocyte Activation Positive Regulation Of Membrane Protein Ectodomain Proteolysis Microglial Cell Activation Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Membrane Protein Ectodomain Proteolysis Leukocyte Activation Involved In Inflammatory Response Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Nitric Oxide Metabolic Process Negative Regulation Of Viral Genome Replication Regulation Of Amyloid Precursor Protein Catabolic Process Cellular Response To Amyloid-beta Positive Regulation Of Calcium-mediated Signaling Leukocyte Cell-cell Adhesion Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Macrophage Activation Response To Amyloid-beta Positive Regulation Of Interleukin-1 Beta Production Regulation Of Inflammatory Response Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Interleukin-1 Production Positive Regulation Of Chemokine Production Positive Regulation Of Neuron Apoptotic Process Regulation Of Innate Immune Response Defense Response Positive Regulation Of Type II Interferon Production Response To External Biotic Stimulus Positive Regulation Of Defense Response Negative Regulation Of Viral Process Regulation Of MiRNA Transcription Regulation Of Viral Genome Replication Antiviral Innate Immune Response Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of MiRNA Metabolic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Bile Acid Secretion Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Interleukin-33 Production Response To Gram-negative Bacterium Negative Regulation Of Branching Involved In Lung Morphogenesis
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