TNIP1 and EFEMP1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		TNIP1	EFEMP1
Gene Name		TNFAIP3 interacting protein 1	EGF containing fibulin-like extracellular matrix protein 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Cytoplasm	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Extracellular Matrix Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin-specific Protease Activity Protein Binding Mitogen-activated Protein Kinase Binding	Epidermal Growth Factor-activated Receptor Activity Epidermal Growth Factor Receptor Binding Calcium Ion Binding Protein Binding Growth Factor Activity
	Biological Process	MyD88-dependent Toll-like Receptor Signaling Pathway Translation Defense Response Inflammatory Response Leukocyte Cell-cell Adhesion Glycoprotein Biosynthetic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Viral Genome Replication Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Inflammatory Response Negative Regulation Of ERK1 And ERK2 Cascade Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade	Regulation Of Transcription, DNA-templated Epidermal Growth Factor Receptor Signaling Pathway Visual Perception Peptidyl-tyrosine Phosphorylation Extracellular Matrix Organization Negative Regulation Of Chondrocyte Differentiation
Pathways			Molecules associated with elastic fibres Elastic fibre formation
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Myasthenia gravis ( 23055271) Psoriasis ( 19169254) Systemic lupus erythematosus ( 23273568 19838193) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 21750679)	Amyotrophic lateral sclerosis ( 19451621) Height ( 20881960 19396169 19893584 23563607 18391951 18391952 20397748 20189936)
Protein-Protein Interactions		61 interactors: ADH6 AP1M1 BYSL CCDC112 CCNG1 CDIP1 CDKN1A CFAP53 EFEMP1 EHHADH FAM161A FAM168A FUS GABARAPL1 GABARAPL2 GIT2 GTF2B GTF2H1 HDDC3 IKBKG KIFC3 MAGEB18 MAGEH1 MAP1LC3A MAP1LC3B MAPK1 MAPK10 MOB1B MOB3C MORF4L1 MORF4L2 NDC80 NFKB1 NIFK NME7 OPTN PIN1 PNKP RABAC1 RALBP1 RARA RARG RBFOX1 RNF11 RPL5 S100B SELPLG SNIP1 SUMO2 SYT6 TAX1BP1 TCEA2 TCEANC2 TNFAIP3 TNIP3 TTF2 TXLNA UBC VPS33B ZBTB25 ZNHIT1	17 interactors: ARAF ATN1 ATXN7 BAG6 CACNA1A GFI1B KHDRBS1 NOS3 RAF1 RERE RIC8A SGTA SOCS6 TIMP3 TNIP1 TRAF2 TXNDC5
Entrez ID		10318	2202
HPRD ID		09216	03331
Ensembl ID		ENSG00000145901	ENSG00000115380
Uniprot IDs		A4F1W8 A4F1W9 A4F1X2 A8K4N4 B7Z8K2 E7EPY1 E7ET96 Q05KP3 Q05KP4 Q15025	B2R6M6 Q12805
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Stress MyD88-independent Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Toll-like Receptor 4 Signaling Pathway Activation Of Innate Immune Response Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Response To Stress Nucleophagy Regulation Of Type I Interferon Production Toll-like Receptor Signaling Pathway Macroautophagy Positive Regulation Of Innate Immune Response Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Mitochondrion Degradation MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Innate Immune Response Organelle Disassembly Autophagic Vacuole Assembly Negative Regulation Of Type I Interferon Production Negative Regulation Of Cytokine Production Cellular Response To Nitrogen Starvation Cellular Response To Stimulus Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Extracellular Stimulus I-kappaB Kinase/NF-kappaB Signaling Immune Response-regulating Signaling Pathway Membrane Fusion Innate Immune Response Fc-epsilon Receptor Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling RNA Metabolic Process Cellular Response To Starvation Cellular Response To DNA Damage Stimulus Membrane Organization Cellular Response To Lipopolysaccharide Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Autophagy Response To Stimulus Fc Receptor Signaling Pathway Defense Response Transcription Initiation From RNA Polymerase II Promoter Response To External Stimulus	Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cell Death Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Regulation Of Cell Death Regulation Of Proteolysis Regulation Of Signaling Regulation Of Cellular Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Phosphorylation Negative Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Regulation Of Signal Transduction Negative Regulation Of Protein Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Lyase Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cell Death Regulation Of Nitrogen Compound Metabolic Process Death Chromatin Modification Negative Regulation Of Signal Transduction Cell-cell Adhesion Involved In Gastrulation Cerebellar Molecular Layer Development Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade Death-inducing Signaling Complex Assembly Cellular Metabolic Process Signal Transduction Regulation Of Cyclase Activity Negative Regulation Of Signaling Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Intracellular Signal Transduction Response To Stress Chromatin Organization Positive Regulation Of Peptidyl-serine Phosphorylation Vestibular Nucleus Development Smooth Muscle Hyperplasia Positive Regulation Of RNA Export From Nucleus Positive Regulation Of Cyclic Nucleotide Metabolic Process Negative Regulation Of Proteolysis Signaling Negative Regulation Of Catalytic Activity Negative Regulation Of Biosynthetic Process Negative Regulation Of Protein Processing
Tagcloud ?		1q21 5q31 6p21 alleles anxa6 applicable atopic conduct dermatitis direction exclusive histocompatibility immunochip influencing loci methodologies mutually opposing overlap overlapping pleiotropic prkra psoriasis rarely shared th2 traits unreported utilizing	aberrant aza chip dac deacetylase deoxycytidine depth downregulation fibulin gc h3 histone immunoprecipitation invasion k9 loci markedly metastasis methylation methyltransferase modification node paired rapidly reactivated silenced silencing trichostatin trimethylation
Tagcloud (Difference) ?		1q21 5q31 6p21 alleles anxa6 applicable atopic conduct dermatitis direction exclusive histocompatibility immunochip influencing methodologies mutually opposing overlap overlapping pleiotropic prkra psoriasis rarely shared th2 traits unreported utilizing	aberrant aza chip dac deacetylase deoxycytidine depth downregulation fibulin gc h3 histone immunoprecipitation invasion k9 markedly metastasis methylation methyltransferase modification node paired rapidly reactivated silenced silencing trichostatin trimethylation
Tagcloud (Intersection) ?		loci