TCIRG1 and TLX3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TCIRG1	TLX3
Description		T cell immune regulator 1, ATPase H+ transporting V0 subunit a3	T cell leukemia homeobox 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Vacuolar Proton-transporting V-type ATPase, V0 Domain Nucleus Lysosome Lysosomal Membrane Late Endosome Plasma Membrane Endosome Membrane Membrane Apical Plasma Membrane Vacuolar Proton-transporting V-type ATPase Complex Secretory Granule Membrane Phagocytic Vesicle Membrane Proton-transporting V-type ATPase Complex Proton-transporting V-type ATPase, V0 Domain Phagocytic Vesicle Ficolin-1-rich Granule Membrane	Chromatin Nucleus Nucleoplasm
	Molecular Function	Protein Binding Proton-transporting ATPase Activity, Rotational Mechanism ATPase Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Autophagosome Assembly Ossification Osteoclast Proliferation Monoatomic Ion Transport Intracellular Calcium Ion Homeostasis Autophagy Apoptotic Process Inflammatory Response Cellular Defense Response Vacuolar Acidification Protein Catabolic Process In The Vacuole Lysosomal Lumen Acidification Positive Regulation Of Cell Population Proliferation Regulation Of Proton Transport Response To Silver Ion Gene Expression Regulation Of Gene Expression Immunoglobulin Mediated Immune Response Macroautophagy Optic Nerve Development Establishment Of Cell Polarity Myeloid Cell Differentiation B Cell Differentiation T Cell Differentiation Osteoclast Differentiation Ruffle Organization Protein Localization To Organelle Memory T Cell Activation T-helper 1 Cell Activation Odontogenesis T Cell Homeostasis Tooth Eruption Bone Resorption Regulation Of Osteoblast Differentiation PH Reduction Homeostasis Of Number Of Cells Regulation Of Insulin Secretion Intracellular PH Reduction Establishment Of Vesicle Localization Retina Development In Camera-type Eye Hematopoietic Stem Cell Homeostasis Enamel Mineralization Cellular Response To Cytokine Stimulus Phagosome Acidification Dentin Mineralization Proton Transmembrane Transport	Neuron Migration Regulation Of Respiratory Gaseous Exchange By Nervous System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Respiratory Gaseous Exchange By Respiratory System Neuron Differentiation Negative Regulation Of Neuron Differentiation Animal Organ Development Neuron Fate Specification GABAergic Neuron Differentiation
Pathways		ROS and RNS production in phagocytes Neutrophil degranulation Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport
Drugs		Tiludronic acid
Diseases		Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor	Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS		Heel bone mineral density ( 30598549) Reticulocyte count ( 32888494)	Body size at age 10 ( 32376654)
Interacting Genes		6 interacting genes: CYTH2 KCNK1 MTDH POGZ TERF1 TLX3	108 interacting genes: ACTMAP ACY1 AKAP9 ANKRD10 ANKRD33 AOC1 APBB1IP ARMC5 ASB12 ATP6V0D1 B9D2 BPIFA1 C2orf42 CEACAM6 CFAP68 CIMIP2B CRX CSNK2B CTNNA3 DENND4A EFEMP2 ERAS FAM168B FCSK FNTB FOSB FOXH1 GGTLC2 GOLGA6L9 GTF2A1L H2BC11 HNF1B HNRNPUL1 HOPX HSPB2 HSPB2-C11orf52 HYI IGFL2 ING4 INTS11 IRF9 ITIH6 KCNJ5-AS1 KRT34 KRTAP11-1 KRTAP13-3 KRTAP19-1 KRTAP19-7 KRTAP3-1 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP8-1 LASP1 LMO2 MAGED1 MEIS1 METTL27 MORN5 MSX2 NDUFAB1 NFIC NFIX NHLRC4 NICN1 OIP5 PLA2G10 PLAAT1 POU2AF1 POU6F2 PPP1CC PQBP1 PRR20A PRR20B PRR20C PRR20D PRR20E PSMB11 REL ROR2 RSKR SERPINE1 SLC15A2 SMU1 SNTA1 SP1 SPATA46 SPMIP9 SPRYD7 STH SYNGAP1 TBX22 TCIRG1 TEKT5 THTPA TLE2 TMEM42 TOX2 TP53BP1 TRIM42 UFSP1 WDR83 YPEL3 ZBTB32 ZNF34 ZNF41 ZNF44
Entrez ID		10312	30012
HPRD ID		05207	06868
Ensembl ID		ENSG00000110719	ENSG00000164438
Uniprot IDs		Q13488	O43711
PDB IDs
Enriched GO Terms of Interacting Partners?		Telomere Maintenance Via Telomere Lengthening RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomere Lengthening Brush Border Membrane Apical Plasma Membrane CTP Binding Chromosome Organization DATP Binding Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly DNA Biosynthetic Process Telomere Maintenance Neurofibrillary Tangle Assembly UTP Binding Regulation Of DNA Biosynthetic Process Sulfonylurea Receptor Binding Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Rho GDP-dissociation Inhibitor Binding Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Bicellular Tight Junction Telomere Organization Ligand-gated Channel Activity Neuron Migration Sperm Mitochondrial Sheath Inward Rectifier Potassium Channel Complex Fibrillar Center Inner Dynein Arm Telomerase Holoenzyme Complex Assembly Regulation Of Establishment Of Protein Localization To Telomere Shelterin Complex Intercellular Canaliculus Chaperone-mediated Autophagy Positive Regulation Of Cardiac Muscle Contraction DNA Metabolic Process Nitric-oxide Synthase Regulator Activity Positive Regulation Of Protein-containing Complex Assembly Inclusion Body Assembly Dendritic Growth Cone Sperm Plasma Membrane TPR Domain Binding Potassium Channel Complex Regulation Of Establishment Of Protein Localization To Chromosome	Intermediate Filament Protein Binding Chromatin
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