TCIRG1 and KCNK1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		TCIRG1	KCNK1
Gene Name		T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3	potassium channel, two pore domain subfamily K, member 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Vacuolar Proton-transporting V-type ATPase, V0 Domain Mitochondrion Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Endosome Membrane Apical Plasma Membrane Vacuolar Proton-transporting V-type ATPase Complex Phagocytic Vesicle Membrane	Endosome Plasma Membrane Voltage-gated Potassium Channel Complex Apical Plasma Membrane Brush Border Membrane
	Molecular Function	Transporter Activity Proton-transporting ATPase Activity, Rotational Mechanism ATPase Binding	Inward Rectifier Potassium Channel Activity
	Biological Process	Cellular Iron Ion Homeostasis Cellular Defense Response Vacuolar Acidification Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway ATP Synthesis Coupled Proton Transport ATP Hydrolysis Coupled Proton Transport Proton Transport Transferrin Transport Interaction With Host Transmembrane Transport Vacuolar Proton-transporting V-type ATPase Complex Assembly Phagosome Maturation	Potassium Ion Transport Synaptic Transmission Regulation Of Ion Transmembrane Transport Response To Nicotine Potassium Ion Transmembrane Transport
Pathways		Phagosomal maturation (early endosomal stage) Iron uptake and transport Latent infection of Homo sapiens with Mycobacterium tuberculosis Transferrin endocytosis and recycling Insulin receptor recycling Signaling by Insulin receptor	Tandem pore domain potassium channels Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) Potassium Channels
Drugs			Ibutilide Quinidine Quinidine barbiturate
Diseases
GWAS			Diabetic retinopathy ( 21441570) Periodontal microbiota ( 22699663)
Protein-Protein Interactions		2 interactors: KCNK1 TERF1	4 interactors: KRTAP10-3 SENP1 TCIRG1 UBE2I
Entrez ID		10312	3775
HPRD ID		05207	03447
Ensembl ID		ENSG00000110719	ENSG00000135750
Uniprot IDs		Q13488	O00180
PDB IDs			3UKM
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomeric Loop Formation Age-dependent Telomere Shortening Telomere Maintenance Via Telomere Shortening Negative Regulation Of Telomere Maintenance Via Telomerase Replicative Cell Aging Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Nuclear Cell Cycle DNA Replication Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Microtubule Polymerization Regulation Of Telomerase Activity Regulation Of Telomere Maintenance RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Regulation Of Microtubule Polymerization Telomere Maintenance Via Telomere Lengthening Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Response To Nicotine Mitotic Spindle Checkpoint Positive Regulation Of Mitotic Nuclear Division Negative Regulation Of Chromosome Segregation Regulation Of DNA Biosynthetic Process Spindle Checkpoint Negative Regulation Of DNA Replication Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Cell Aging Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Cellular Protein Catabolic Process Telomere Maintenance Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Protein Catabolic Process G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Polymerization Regulation Of Mitotic Nuclear Division Regulation Of DNA Replication Positive Regulation Of Cell Division Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Microtubule Cytoskeleton Organization	Protein Sumoylation Positive Regulation Of SUMO Transferase Activity Post-translational Protein Modification Peptidyl-lysine Modification Protein Desumoylation Regulation Of Definitive Erythrocyte Differentiation Vacuolar Proton-transporting V-type ATPase Complex Assembly Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Vacuolar Acidification Protein Modification By Small Protein Conjugation Intracellular PH Reduction PH Reduction
Tagcloud ?		akt2 caii clcn7 destructive erk2 flavonoid gab2 glabridin holds homeostatically jnk1 licorice master mkk7 multinucleated nfatc1 osteoblastic osteoclast osteoclastic osteoclastogenesis osteoclastogenic osteoclasts ostm1 pit rankl raw264 resorption resorptive tartrate	actinomycetemcomitans affymetrix aggregatibacter camta1 ceu characterizes checkerboard colonization correction direction fbxo38 genotyping gwa hapmap il33 imputation loci microbiome microbiota orange periodontal periodontitis replicating runx2 shifts suggestive trps1 uhrf2 vamp3
Tagcloud (Difference) ?		akt2 caii clcn7 destructive erk2 flavonoid gab2 glabridin holds homeostatically jnk1 licorice master mkk7 multinucleated nfatc1 osteoblastic osteoclast osteoclastic osteoclastogenesis osteoclastogenic osteoclasts ostm1 pit rankl raw264 resorption resorptive tartrate	actinomycetemcomitans affymetrix aggregatibacter camta1 ceu characterizes checkerboard colonization correction direction fbxo38 genotyping gwa hapmap il33 imputation loci microbiome microbiota orange periodontal periodontitis replicating runx2 shifts suggestive trps1 uhrf2 vamp3
Tagcloud (Intersection) ?