TCIRG1 and POGZ

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TCIRG1	POGZ
Description		T cell immune regulator 1, ATPase H+ transporting V0 subunit a3	pogo transposable element derived with ZNF domain
Image		No pdb structure
GO Annotations	Cellular Component	Vacuolar Proton-transporting V-type ATPase, V0 Domain Nucleus Lysosome Lysosomal Membrane Late Endosome Plasma Membrane Endosome Membrane Membrane Apical Plasma Membrane Vacuolar Proton-transporting V-type ATPase Complex Secretory Granule Membrane Phagocytic Vesicle Membrane Proton-transporting V-type ATPase Complex Proton-transporting V-type ATPase, V0 Domain Phagocytic Vesicle Ficolin-1-rich Granule Membrane	Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Plasma Membrane Ciliary Basal Body
	Molecular Function	Protein Binding Proton-transporting ATPase Activity, Rotational Mechanism ATPase Binding	Nucleic Acid Binding DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Autophagosome Assembly Ossification Osteoclast Proliferation Monoatomic Ion Transport Intracellular Calcium Ion Homeostasis Autophagy Apoptotic Process Inflammatory Response Cellular Defense Response Vacuolar Acidification Protein Catabolic Process In The Vacuole Lysosomal Lumen Acidification Positive Regulation Of Cell Population Proliferation Regulation Of Proton Transport Response To Silver Ion Gene Expression Regulation Of Gene Expression Immunoglobulin Mediated Immune Response Macroautophagy Optic Nerve Development Establishment Of Cell Polarity Myeloid Cell Differentiation B Cell Differentiation T Cell Differentiation Osteoclast Differentiation Ruffle Organization Protein Localization To Organelle Memory T Cell Activation T-helper 1 Cell Activation Odontogenesis T Cell Homeostasis Tooth Eruption Bone Resorption Regulation Of Osteoblast Differentiation PH Reduction Homeostasis Of Number Of Cells Regulation Of Insulin Secretion Intracellular PH Reduction Establishment Of Vesicle Localization Retina Development In Camera-type Eye Hematopoietic Stem Cell Homeostasis Enamel Mineralization Cellular Response To Cytokine Stimulus Phagosome Acidification Dentin Mineralization Proton Transmembrane Transport	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination DNA Damage Response Mitotic Sister Chromatid Cohesion Positive Regulation Of Transcription By RNA Polymerase II Cell Division Kinetochore Assembly
Pathways		ROS and RNS production in phagocytes Neutrophil degranulation Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport
Drugs		Tiludronic acid
Diseases		Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor
GWAS		Heel bone mineral density ( 30598549) Reticulocyte count ( 32888494)	Blood trace element (Cu levels) ( 23720494) Body mass index ( 26426971) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Pulse pressure ( 30578418)
Interacting Genes		6 interacting genes: CYTH2 KCNK1 MTDH POGZ TERF1 TLX3	87 interacting genes: A1CF ACTMAP AGR2 ANKRD10 AOC1 APP ATXN1 BANP BOLL C10orf55 CCDC136 CDK6 CERCAM CREB1 CRX DAB1 DAZAP2 DMXL1 DTX2 EID2B EIF3F EYA2 FAM168B FCSK FHL2 FNDC3B FOSB GABPB1 GMEB2 H3-4 HGS HIVEP1 HSF2BP HSPB2 HSPB2-C11orf52 HYI JMJD7 KLHDC7B KLHL26 KRTAP3-2 KRTAP6-2 KRTAP8-1 LITAF MBLAC1 MYO1B NFYA NFYC NHLRC4 NICN1 NRF1 ODAM PFDN5 PIDD1 PLEKHB2 PLIN2 POU2AF1 POU2F1 PRR20A PRR20B PRR20C PRR20D PRR20E QRICH1 RBFOX1 RBPMS RSPH1 SP1 SP3 SP4 SPATA12 SPRYD7 STH SUMO2 TBX19 TCIRG1 TMBIM4 TSC1 UFSP1 VAV2 VEZF1 VGLL3 ZBTB24 ZNF143 ZNF410 ZNF710 ZNF76 ZXDC
Entrez ID		10312	23126
HPRD ID		05207	11445
Ensembl ID		ENSG00000110719	ENSG00000143442
Uniprot IDs		Q13488	A0A8V8TQ67 Q7Z3K3
PDB IDs			2E72 2N3A 6EMP
Enriched GO Terms of Interacting Partners?		Telomere Maintenance Via Telomere Lengthening RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomere Lengthening Brush Border Membrane Apical Plasma Membrane CTP Binding Chromosome Organization DATP Binding Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly DNA Biosynthetic Process Telomere Maintenance Neurofibrillary Tangle Assembly UTP Binding Regulation Of DNA Biosynthetic Process Sulfonylurea Receptor Binding Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Rho GDP-dissociation Inhibitor Binding Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Bicellular Tight Junction Telomere Organization Ligand-gated Channel Activity Neuron Migration Sperm Mitochondrial Sheath Inward Rectifier Potassium Channel Complex Fibrillar Center Inner Dynein Arm Telomerase Holoenzyme Complex Assembly Regulation Of Establishment Of Protein Localization To Telomere Shelterin Complex Intercellular Canaliculus Chaperone-mediated Autophagy Positive Regulation Of Cardiac Muscle Contraction DNA Metabolic Process Nitric-oxide Synthase Regulator Activity Positive Regulation Of Protein-containing Complex Assembly Inclusion Body Assembly Dendritic Growth Cone Sperm Plasma Membrane TPR Domain Binding Potassium Channel Complex Regulation Of Establishment Of Protein Localization To Chromosome	Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Protein Binding DNA Binding Positive Regulation Of Macromolecule Metabolic Process Nucleus DNA-binding Transcription Factor Activity Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Transcription Regulator Complex Protein-DNA Complex DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process CCAAT-binding Factor Complex Identical Protein Binding Sequence-specific DNA Binding Regulation Of Macromolecule Metabolic Process Sequence-specific Double-stranded DNA Binding Adult Locomotory Behavior
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