Wiki-Pi
Answer Survey
Home
About
Help
Advanced Search
CCDC90B and CDKN2B
Number of citations of the paper that reports this interaction (PMID
16169070
)
531
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
CCDC90B
CDKN2B
Gene Name
coiled-coil domain containing 90B
cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Mitochondrion
Integral Component Of Membrane
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Molecular Function
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Protein Binding
Protein Kinase Binding
Biological Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
G2/M Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Liver Development
Transcription, DNA-templated
Transcription Initiation From RNA Polymerase II Promoter
Cell Cycle Arrest
Mitotic Cell Cycle Checkpoint
Transforming Growth Factor Beta Receptor Signaling Pathway
Aging
Negative Regulation Of Cell Proliferation
Gene Expression
Response To Organic Cyclic Compound
Megakaryocyte Differentiation
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Epithelial Cell Differentiation
Cellular Response To Extracellular Stimulus
Cellular Response To Nutrient
Response To Cytokine
Negative Regulation Of Phosphorylation
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Spleen Development
Negative Regulation Of Epithelial Cell Proliferation
Negative Regulation Of Protein Serine/threonine Kinase Activity
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Loss of Function of TGFBR2 in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
Cellular Senescence
Oncogene Induced Senescence
TGFBR1 LBD Mutants in Cancer
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Generic Transcription Pathway
Mitotic G1-G1/S phases
TGFBR2 MSI Frameshift Mutants in Cancer
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Loss of Function of SMAD2/3 in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
G1 Phase
Senescence-Associated Secretory Phenotype (SASP)
TGFBR1 KD Mutants in Cancer
Cell Cycle, Mitotic
Loss of Function of TGFBR1 in Cancer
Cyclin D associated events in G1
Signaling by TGF-beta Receptor Complex in Cancer
Signaling by TGF-beta Receptor Complex
Oxidative Stress Induced Senescence
SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Ankle-brachial index (
22199011
)
Breast cancer (
23535729
20453838
)
Coronary artery calcification (
22144573
23561647
)
Coronary heart disease (
21626137
21971053
17554300
21378990
)
Endometriosis (
23104006
)
Fasting glucose-related traits (interaction with BMI) (
22581228
)
Glaucoma (
22792221
)
Glaucoma (primary open-angle) (
22419738
)
Glioma (
21531791
19578367
)
Intracranial aneurysm (
18997786
20364137
)
Myocardial infarction (
17478679
)
Myocardial infarction (early onset) (
19198609
)
Nasopharyngeal carcinoma (
20512145
)
Type 2 diabetes (
21573907
18372903
22293688
22961080
20581827
19401414
17463246
17463248
17463249
19056611
)
Vertical cup-disc ratio (
20548946
)
Protein-Protein Interactions
29 interactors:
AGR2
ANXA7
ARL15
BTBD2
CDKN2B
CDKN2C
DLEU1
DNM2
EIF2S2
FXYD6
KDM1A
LAMTOR1
NACA
NIPSNAP3A
PAFAH1B3
PCDHA4
PIN1
PNP
PRDX5
PSMD11
RGL2
RNF10
SAT1
SDHAF2
SERPINB9
SMN1
TAC3
TK1
TSC22D1
15 interactors:
APP
ARPC3
CCDC33
CCDC90B
CDK4
CDK6
CDK8
IKBKAP
ISL1
KIAA1377
MAGEA11
NIF3L1
TGFB1I1
TRAF1
ZBTB17
Entrez ID
60492
1030
HPRD ID
14378
02696
Ensembl ID
ENSG00000137500
ENSG00000147883
Uniprot IDs
B3KP87
Q9GZT6
K7PPU3
P42772
PDB IDs
Enriched GO Terms of Interacting Partners
?
Regulation Of Cell Proliferation
Developmental Process
System Development
Anatomical Structure Development
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Negative Regulation Of Cellular Protein Metabolic Process
Nucleoside Metabolic Process
Negative Regulation Of Protein Metabolic Process
Nucleotide Metabolic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Negative Regulation Of Cell Death
Multicellular Organismal Development
Reactive Nitrogen Species Metabolic Process
Nucleobase-containing Small Molecule Metabolic Process
Regulation Of Catalytic Activity
Regulation Of Apoptotic Process
Regulation Of Cell Death
Regulation Of Cell Differentiation
Negative Regulation Of Cellular Metabolic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter Involved In Heart Development
Inosine Catabolic Process
Regulation Of Apoptosis Involved In Tissue Homeostasis
Regulation Of Primitive Erythrocyte Differentiation
Nicotinamide Riboside Catabolic Process
Fetal Process Involved In Parturition
Mitochondrial Electron Transport, Succinate To Ubiquinone
NAD Biosynthesis Via Nicotinamide Riboside Salvage Pathway
Negative Regulation Of Catalytic Activity
Positive Regulation Of Metabolic Process
Nitrogen Compound Metabolic Process
Negative Regulation Of Membrane Tubulation
Mucus Secretion
Spermidine Acetylation
Skeletal Muscle Cell Proliferation
Interleukin-2 Secretion
Urate Biosynthetic Process
Purine Nucleoside Metabolic Process
Positive Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Ligase Activity
Cellular Nitrogen Compound Metabolic Process
Regulation Of Oxidoreductase Activity
Endosome Localization
Lung Goblet Cell Differentiation
Protein-FAD Linkage
Regulation Of Cholesterol Import
Putrescine Catabolic Process
Positive Regulation Of Skeletal Muscle Tissue Growth
Response To Stimulus
Positive Regulation Of Gene Expression
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Gene Expression
Positive Regulation Of Transcription, DNA-templated
Notch Signaling Pathway
Positive Regulation Of Metabolic Process
Regulation Of Cell Cycle
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Positive Regulation Of Cellular Metabolic Process
Cellular Response To Stimulus
Regulation Of Protein Phosphorylation
Signal Transduction
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Signaling
Regulation Of Cell Cycle G2/M Phase Transition
Regulation Of Transcription, DNA-templated
Regulation Of Phosphorylation
Protein Phosphorylation
Cell Communication
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Metabolic Process
Positive Regulation Of Mitotic Cell Cycle Phase Transition
Negative Regulation Of Cell Differentiation
Regulation Of RNA Metabolic Process
Regulation Of Protein Kinase Activity
Positive Regulation Of Cell Cycle Phase Transition
Regulation Of Kinase Activity
Positive Regulation Of Fibroblast Proliferation
Regulation Of Phosphorus Metabolic Process
Cell Dedifferentiation
Anatomical Structure Morphogenesis
Cell Projection Morphogenesis
Cell Part Morphogenesis
Transcription From RNA Polymerase II Promoter
Anatomical Structure Development
Response To Stimulus
Regulation Of Nitrogen Compound Metabolic Process
Axon Guidance
Positive Regulation Of Macrophage Colony-stimulating Factor Production
Synaptic Growth At Neuromuscular Junction
Positive Regulation Of Granulocyte Colony-stimulating Factor Production
7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process
Pancreas Development
Regulation Of Fibroblast Proliferation
Forebrain Development
Negative Regulation Of Cell Cycle
Phosphorylation
Cell Morphogenesis
Tagcloud
?
a134c
abp
allelic
ankyrin
balb
cdk6
cdnas
chr
congenic
d2
dba
g232a
ifna
inbred
inefficient
ink4c
le
multigenic
mus
p15
p16
p18
pctr1
plasmacytoma
pristane
spretus
typed
Tagcloud (Difference)
?
a134c
abp
allelic
ankyrin
balb
cdk6
cdnas
chr
congenic
d2
dba
g232a
ifna
inbred
inefficient
ink4c
le
multigenic
mus
p15
p16
p18
pctr1
plasmacytoma
pristane
spretus
typed
Tagcloud (Intersection)
?