PAK4 and H1-1

Number of citations of the paper that reports this interaction (PubMedID 26598620)
63

Data Source:
BioGRID (enzymatic study)

		PAK4	H1-1
Description		p21 (RAC1) activated kinase 4	H1.1 linker histone, cluster member
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GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Adherens Junction Focal Adhesion	Chromatin Nucleosome Euchromatin Nucleus Nucleoplasm Chromosome Cell Surface Vesicle
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein-macromolecule Adaptor Activity Cadherin Binding Involved In Cell-cell Adhesion Protein Serine Kinase Activity	DNA Binding Double-stranded DNA Binding Protein Binding Heparin Binding Structural Constituent Of Chromatin Chromatin DNA Binding Nucleosomal DNA Binding
	Biological Process	Regulation Of Cell Growth Apoptotic Process Cytoskeleton Organization Signal Transduction Cellular Response To Starvation Cell Migration Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Angiogenesis Protein Stabilization Dendritic Spine Development Cell-cell Adhesion Positive Regulation Of Focal Adhesion Disassembly Negative Regulation Of Endothelial Cell Apoptotic Process	Nucleosome Assembly Spermatogenesis Chromosome Condensation Negative Regulation Of DNA Recombination Positive Regulation Of Receptor-mediated Endocytosis
Pathways		Activation of RAC1 CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle	Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs		Fostamatinib
Diseases
GWAS
Interacting Genes		23 interacting genes: APP CDC42 DGCR6L DLST FBXO25 FGFR2 G6PD GATAD2A GRB2 H1-1 ITGAV ITGB5 LIMK1 POT1 PPARG RAN RHOU SH3RF2 SRPK1 SRPK2 TERF1 YWHAG YWHAZ	54 interacting genes: AEBP2 APP CCNA1 CCNA2 CCNB1 CCND2 CCNE1 CDK1 CDK11B CDK2 CDK4 CDK5 CDK6 CDK7 CDKN1B CRP CTCFL EED EHMT2 EP300 EZH2 GADD45A GZMA IRAK4 KAT2B LIMK1 LIMK2 LOX NAP1L1 NAP1L4 NASP NSD3 PAK4 PARP1 PARP3 PELP1 PRDM1 PRKCA PRKCB PRKCD PRKCE PRKCZ PRKDC PTMA RBBP4 RPS6KA5 SET SMYD5 SNCA SUZ12 TAF1 TERF1 TERF2IP TLK1
Entrez ID		10298	3024
HPRD ID		05675	00820
Ensembl ID		ENSG00000130669	ENSG00000124610
Uniprot IDs		O96013	Q02539
PDB IDs		2BVA 2CDZ 2J0I 2OV2 2Q0N 2X4Z 4APP 4FIE 4FIF 4FIG 4FIH 4FII 4FIJ 4JDH 4JDI 4JDJ 4JDK 4L67 4NJD 4O0V 4O0X 4O0Y 4XBR 4XBU 5BMS 5I0B 5UPK 5UPL 5VED 5VEE 5VEF 5XVA 5XVF 5XVG 5ZJW 6WLX 6WLY 7CMB 7CP3 7CP4 7S46 7S47 7S48 8AHG 8AHH 8AHI 8YHK	9J8O
Enriched GO Terms of Interacting Partners?		Focal Adhesion Integrin Alphav-beta5 Complex Intracellular Signal Transduction Actin Cytoskeleton Organization Intracellular Signaling Cassette Actin Filament-based Process Endodermal Cell Differentiation Regulation Of MAPK Cascade Regulation Of Cellular Component Organization Shelterin Complex Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Establishment Of Golgi Localization Positive Regulation Of Cellular Component Organization Negative Regulation Of Metabolic Process Positive Regulation Of Supramolecular Fiber Organization Nucleus Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Branching Involved In Labyrinthine Layer Morphogenesis Nuclear Telomere Cap Complex Telomeric D-loop Disassembly G-rich Strand Telomeric DNA Binding Protein Phosphorylation Telomeric Loop Disassembly Regulation Of Protein Localization Receptor Complex Regulation Of Intracellular Signal Transduction Phosphorylation Negative Regulation Of Macrophage Derived Foam Cell Differentiation Telomere Capping Golgi Localization Innate Immune Response Organelle Organization Negative Regulation Of Immune Response Wound Healing, Spreading Of Epidermal Cells Negative Regulation Of Macromolecule Metabolic Process Phagocytic Vesicle Protein Domain Specific Binding Chromosome Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Endocytosis Identical Protein Binding Phosphate-containing Compound Metabolic Process Negative Regulation Of Innate Immune Response Integrin-mediated Signaling Pathway Defense Response To Symbiont Negative Regulation Of Telomere Maintenance Via Telomerase Actin Filament Organization Small GTPase-mediated Signal Transduction Fibroblast Growth Factor Binding Negative Regulation Of Lipid Storage	Chromatin Organization Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Chromatin Remodeling Nucleus Protein Kinase Activity Kinase Activity Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of Nucleobase-containing Compound Metabolic Process Transferase Activity G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Protein Phosphorylation Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Phosphorylation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Mitotic Cell Cycle Phase Transition Regulation Of Metabolic Process Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Cell Cycle Cell Cycle Phase Transition Regulation Of Cell Cycle Process Negative Regulation Of Metabolic Process Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Cellular Response To Stress Cellular Response To Oxygen-containing Compound Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone Binding Positive Regulation Of Macromolecule Metabolic Process Protein Modification Process Response To Stress Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Negative Regulation Of RNA Metabolic Process ESC/E(Z) Complex Regulation Of Cell Cycle Phase Transition Cell Division Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Localization To Chromosome
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