PAK4 and G6PD

Number of citations of the paper that reports this interaction (PubMedID 28542136)
44

Data Source:
BioGRID (pull down, affinity chromatography technology)

		PAK4	G6PD
Description		p21 (RAC1) activated kinase 4	glucose-6-phosphate dehydrogenase
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GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Adherens Junction Focal Adhesion	Cytoplasm Cytosol Cytoplasmic Side Of Plasma Membrane Membrane Centriolar Satellite Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein-macromolecule Adaptor Activity Cadherin Binding Involved In Cell-cell Adhesion Protein Serine Kinase Activity	Glucose-6-phosphate Dehydrogenase Activity Protein Binding D-glucose Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On CH-OH Group Of Donors Carbohydrate Binding Identical Protein Binding Protein Homodimerization Activity NADP Binding
	Biological Process	Regulation Of Cell Growth Apoptotic Process Cytoskeleton Organization Signal Transduction Cellular Response To Starvation Cell Migration Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Angiogenesis Protein Stabilization Dendritic Spine Development Cell-cell Adhesion Positive Regulation Of Focal Adhesion Disassembly Negative Regulation Of Endothelial Cell Apoptotic Process	Glucose Metabolic Process Pentose-phosphate Shunt Lipid Metabolic Process Cholesterol Biosynthetic Process NADP+ Metabolic Process NADPH Regeneration Glutathione Metabolic Process Pentose-phosphate Shunt, Oxidative Branch Response To Iron(III) Ion Pentose Biosynthetic Process Substantia Nigra Development Response To Food Cellular Response To Oxidative Stress Erythrocyte Maturation Regulation Of Neuron Apoptotic Process Response To Ethanol Ribose Phosphate Biosynthetic Process Glucose 6-phosphate Metabolic Process Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Activation of RAC1 CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle	TP53 Regulates Metabolic Genes Pentose phosphate pathway NFE2L2 regulates pentose phosphate pathway genes
Drugs		Fostamatinib	Glycolic acid Nicotinamide adenine dinucleotide phosphate 16-Bromoepiandrosterone Artenimol
Diseases			Anemia due to disorders of glutathione metabolism, including: Glucose-6-phosphate dehydrogenase (G6PD) deficiency; Glutathione peroxidase (GPX) deficiency; Gamma-glutamylcysteine synthetase (GCLC) deficiency; Glutathione synthetase (GSS) deficiency Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS			Bilirubin levels ( 19419973) Glycated hemoglobin levels ( 28898252 31213470 34059833) Hemoglobin levels ( 26366553) hemolysis of donated blood (oxidative) ( 34014839) Mean corpuscular hemoglobin ( 28453575) Mean corpuscular volume ( 28453575) Red blood cell count ( 28453575) Red blood cell traits ( 23446634 23696099) Red cell distribution width ( 28453575)
Interacting Genes		23 interacting genes: APP CDC42 DGCR6L DLST FBXO25 FGFR2 G6PD GATAD2A GRB2 H1-1 ITGAV ITGB5 LIMK1 POT1 PPARG RAN RHOU SH3RF2 SRPK1 SRPK2 TERF1 YWHAG YWHAZ	5 interacting genes: CDC42 LINC00624 LINC01554 PAK4 SUMO4
Entrez ID		10298	2539
HPRD ID		05675	02377
Ensembl ID		ENSG00000130669	ENSG00000160211
Uniprot IDs		O96013	A0A384NL00 P11413
PDB IDs		2BVA 2CDZ 2J0I 2OV2 2Q0N 2X4Z 4APP 4FIE 4FIF 4FIG 4FIH 4FII 4FIJ 4JDH 4JDI 4JDJ 4JDK 4L67 4NJD 4O0V 4O0X 4O0Y 4XBR 4XBU 5BMS 5I0B 5UPK 5UPL 5VED 5VEE 5VEF 5XVA 5XVF 5XVG 5ZJW 6WLX 6WLY 7CMB 7CP3 7CP4 7S46 7S47 7S48 8AHG 8AHH 8AHI 8YHK	1QKI 2BH9 2BHL 5UKW 6E07 6E08 6JYU 6VA0 6VA7 6VA8 6VA9 6VAQ 7SEH 7SEI 7SNF 7SNG 7SNH 7SNI 7TOE 7TOF 7UAG 7UAL 7UC2 7ZVD
Enriched GO Terms of Interacting Partners?		Focal Adhesion Integrin Alphav-beta5 Complex Intracellular Signal Transduction Actin Cytoskeleton Organization Intracellular Signaling Cassette Actin Filament-based Process Endodermal Cell Differentiation Regulation Of MAPK Cascade Regulation Of Cellular Component Organization Shelterin Complex Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Establishment Of Golgi Localization Positive Regulation Of Cellular Component Organization Negative Regulation Of Metabolic Process Positive Regulation Of Supramolecular Fiber Organization Nucleus Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Branching Involved In Labyrinthine Layer Morphogenesis Nuclear Telomere Cap Complex Telomeric D-loop Disassembly G-rich Strand Telomeric DNA Binding Protein Phosphorylation Telomeric Loop Disassembly Regulation Of Protein Localization Receptor Complex Regulation Of Intracellular Signal Transduction Phosphorylation Negative Regulation Of Macrophage Derived Foam Cell Differentiation Telomere Capping Golgi Localization Innate Immune Response Organelle Organization Negative Regulation Of Immune Response Wound Healing, Spreading Of Epidermal Cells Negative Regulation Of Macromolecule Metabolic Process Phagocytic Vesicle Protein Domain Specific Binding Chromosome Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Endocytosis Identical Protein Binding Phosphate-containing Compound Metabolic Process Negative Regulation Of Innate Immune Response Integrin-mediated Signaling Pathway Defense Response To Symbiont Negative Regulation Of Telomere Maintenance Via Telomerase Actin Filament Organization Small GTPase-mediated Signal Transduction Fibroblast Growth Factor Binding Negative Regulation Of Lipid Storage
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