TRAIP and RNF4

Number of citations of the paper that reports this interaction (PMID 22493164)
2

Data Source:
BioGRID (two hybrid)

		TRAIP	RNF4
Gene Name		TRAF interacting protein	ring finger protein 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleolus Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm PML Body
	Molecular Function	Ubiquitin-protein Transferase Activity Receptor Signaling Protein Activity Protein Binding Zinc Ion Binding Ligase Activity	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Ligase Activity Nucleosome Binding SUMO Polymer Binding Identical Protein Binding Androgen Receptor Binding
	Biological Process	Apoptotic Process Signal Transduction Cell Proliferation Protein Ubiquitination Intracellular Signal Transduction	Transcription, DNA-templated Androgen Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Arsenic-containing Substance Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination Regulation Of Spindle Assembly Regulation Of Kinetochore Assembly
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		22 interactors: APP CYLD FLII MAPRE2 POLK RNF114 RNF4 TNFRSF1B TRAF1 TRAF2 TRIM23 TRIM41 TSG101 UBE2D1 UBE2D2 UBE2D3 UBE2H UBE2K UBE2U UBE2Z UBOX5 USP2	37 interactors: AR ATXN1 ESR1 GSC2 HIST2H3C HMGA1 HNF4A IKBKG MECP2 PATZ1 PGR PML SKIL SP1 SRPK2 SUMO1 SUMO2 TBP TCF20 TRAIP TRIM28 TRPS1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2K UBE2L6 UBE2T UBE2W UEVLD
Entrez ID		10293	6047
HPRD ID		05811	04167
Ensembl ID		ENSG00000183763	ENSG00000063978
Uniprot IDs		Q9BWF2	P78317
PDB IDs			2EA6 2XEU
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K48-linked Ubiquitination Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Modification Process Cellular Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Pattern Recognition Receptor Signaling Pathway Protein Metabolic Process Innate Immune Response-activating Signal Transduction Catabolic Process Activation Of Innate Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway Proteolysis MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Protein K11-linked Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Programmed Cell Death Cell Death Death Regulation Of Innate Immune Response Toll-like Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Apoptotic Process Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Proteolysis Cellular Metabolic Process Cellular Response To Stress Immune Response-regulating Signaling Pathway Innate Immune Response Cellular Response To Hypoxia Immune Response Cellular Response To Decreased Oxygen Levels Defense Response Positive Regulation Of Proteolysis Regulation Of Cell Cycle Cellular Response To Oxygen Levels Positive Regulation Of Immune Response Regulation Of Protein Catabolic Process Regulation Of Gene Expression	Protein K48-linked Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Protein Ubiquitination Transcription Initiation From RNA Polymerase II Promoter Protein K11-linked Ubiquitination DNA-templated Transcription, Initiation Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Protein Modification Process Regulation Of RNA Metabolic Process Transcription, DNA-templated Modification-dependent Protein Catabolic Process RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Protein Catabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Gene Expression Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Heterocycle Metabolic Process Transcription From RNA Polymerase II Promoter Cellular Aromatic Compound Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Intracellular Receptor Signaling Pathway Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Cellular Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway ISG15-protein Conjugation
Tagcloud ?		anteroventral aromatization avpv bcl2 cyclic dense describing dictated estradiol fertility herein historical hypothalamus lh luteinizing males mammals nfkappab perinatal periventricular perspective proposing rodents surge testosterone tnfalpha tonic triggered update	barrier begins calculations catalyzed conjugating d117 deprotonation dimeric e3 elusive employing gets guiding kcal ligase ligases md mechanics nucleophilic oxyanion qm ring sumo2 thioester transfer ub ubch5a ubiquitylation universal
Tagcloud (Difference) ?		anteroventral aromatization avpv bcl2 cyclic dense describing dictated estradiol fertility herein historical hypothalamus lh luteinizing males mammals nfkappab perinatal periventricular perspective proposing rodents surge testosterone tnfalpha tonic triggered update	barrier begins calculations catalyzed conjugating d117 deprotonation dimeric e3 elusive employing gets guiding kcal ligase ligases md mechanics nucleophilic oxyanion qm ring sumo2 thioester transfer ub ubch5a ubiquitylation universal
Tagcloud (Intersection) ?