TRAIP and UBE2Z

Number of citations of the paper that reports this interaction (PMID 19549727)
40

Data Source:
BioGRID (two hybrid)

		TRAIP	UBE2Z
Gene Name		TRAF interacting protein	ubiquitin-conjugating enzyme E2Z
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleolus Perinuclear Region Of Cytoplasm	Nucleoplasm Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Receptor Signaling Protein Activity Protein Binding Zinc Ion Binding Ligase Activity	Protein Binding ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Apoptotic Process Signal Transduction Cell Proliferation Protein Ubiquitination Intracellular Signal Transduction	Protein Polyubiquitination Apoptotic Process
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS			Coronary heart disease ( 21378990)
Protein-Protein Interactions		22 interactors: APP CYLD FLII MAPRE2 POLK RNF114 RNF4 TNFRSF1B TRAF1 TRAF2 TRIM23 TRIM41 TSG101 UBE2D1 UBE2D2 UBE2D3 UBE2H UBE2K UBE2U UBE2Z UBOX5 USP2	31 interactors: AK8 BMPR1B DZIP3 HLTF HMBOX1 LNX2 LPL MDM2 PLEKHF2 PPP1CA RAPSN REL RNF103 RNF130 RNF139 RNF144B RNF150 RNF166 RNF41 RNF5 SMAD1 SMAD4 SRA1 SYVN1 TGFBR1 TRAIP TRIM27 TRIM46 TRIM65 UBA6 UBD
Entrez ID		10293	65264
HPRD ID		05811	08589
Ensembl ID		ENSG00000183763	ENSG00000159202
Uniprot IDs		Q9BWF2	Q9H832
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K48-linked Ubiquitination Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Modification Process Cellular Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Pattern Recognition Receptor Signaling Pathway Protein Metabolic Process Innate Immune Response-activating Signal Transduction Catabolic Process Activation Of Innate Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway Proteolysis MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Protein K11-linked Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Programmed Cell Death Cell Death Death Regulation Of Innate Immune Response Toll-like Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Apoptotic Process Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Proteolysis Cellular Metabolic Process Cellular Response To Stress Immune Response-regulating Signaling Pathway Innate Immune Response Cellular Response To Hypoxia Immune Response Cellular Response To Decreased Oxygen Levels Defense Response Positive Regulation Of Proteolysis Regulation Of Cell Cycle Cellular Response To Oxygen Levels Positive Regulation Of Immune Response Regulation Of Protein Catabolic Process Regulation Of Gene Expression	Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Cellular Protein Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Metabolic Process Protein Catabolic Process Regulation Of Cell Death Cellular Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Polyubiquitination Cellular Macromolecule Catabolic Process Protein Destabilization Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway ER-associated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Apoptotic Process Endothelial Cell Activation Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of SMAD Protein Import Into Nucleus Apoptotic Process Negative Regulation Of Cell Proliferation SMAD Protein Complex Assembly BMP Signaling Pathway Regulation Of SMAD Protein Import Into Nucleus Programmed Cell Death Cell Death Death Regulation Of Cartilage Development Response To Stress Proteasomal Protein Catabolic Process Proteolysis Triglyceride Catabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Gene Expression Regulation Of Signaling Cardiac Epithelial To Mesenchymal Transition Acylglycerol Catabolic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Process Response To Growth Factor Negative Regulation Of Gene Expression Positive Regulation Of Programmed Cell Death Metabolic Process
Tagcloud ?		anteroventral aromatization avpv bcl2 cyclic dense describing dictated estradiol fertility herein historical hypothalamus lh luteinizing males mammals nfkappab perinatal periventricular perspective proposing rodents surge testosterone tnfalpha tonic triggered update	array c9orf72 carriers conjugating consisting deregulation discovery displays encode except expansion frontotemporal ftd generalized grn matched preliminary proteasomal proteasome sabiosciences sporadic statistically ube2e1 ube2i ube2n ube2q1 ubiquitin ubiquitination
Tagcloud (Difference) ?		anteroventral aromatization avpv bcl2 cyclic dense describing dictated estradiol fertility herein historical hypothalamus lh luteinizing males mammals nfkappab perinatal periventricular perspective proposing rodents surge testosterone tnfalpha tonic triggered update	array c9orf72 carriers conjugating consisting deregulation discovery displays encode except expansion frontotemporal ftd generalized grn matched preliminary proteasomal proteasome sabiosciences sporadic statistically ube2e1 ube2i ube2n ube2q1 ubiquitin ubiquitination
Tagcloud (Intersection) ?