TRAIP and POLK

Number of citations of the paper that reports this interaction (PubMedID 24553286)
81

Data Source:
BioGRID (two hybrid)

		TRAIP	POLK
Description		TRAF interacting protein	DNA polymerase kappa
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Perinuclear Region Of Cytoplasm Site Of DNA Damage	Nucleus Nucleoplasm Nuclear Body Site Of DNA Damage
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	DNA Binding Damaged DNA Binding DNA-directed DNA Polymerase Activity Zinc Ion Binding Transferase Activity Nucleotidyltransferase Activity DNA Polymerase Activity Metal Ion Binding
	Biological Process	DNA Repair Apoptotic Process DNA Damage Response Signal Transduction Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Ubiquitination Replication Fork Processing Negative Regulation Of Interferon-beta Production Protein-DNA Covalent Cross-linking Repair	DNA Replication DNA Repair Nucleotide-excision Repair, DNA Gap Filling DNA Damage Response Cellular Response To UV Error-prone Translesion Synthesis DNA Biosynthetic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Translesion synthesis by POLK Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER
Drugs			1,2,3-TRIHYDROXY-1,2,3,4-TETRAHYDROBENZO[A]PYRENE 1-[2-DEOXYRIBOFURANOSYL]-2,4-DIFLUORO-5-METHYL-BENZENE-5'MONOPHOSPHATE 2'-deoxy-N-(naphthalen-1-ylmethyl)guanosine 5'-(dihydrogen phosphate)
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels ( 30388399) Cortical surface area (MOSTest) ( 32665545) Extremely high intelligence ( 29520040) Fasting insulin ( 34059833) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Mental health study participation (provided email address) ( 31263887) Multisite chronic pain ( 33830993) Refractive error ( 32231278) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Tea consumption ( 31046077) Walking pace ( 33128006)	Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634)
Interacting Genes		29 interacting genes: ALOX15B APP CEP19 CYLD FLII LXN MAGEF1 MAPRE2 MAPRE3 POLK POLR1C RNF114 RNF4 TNFRSF1B TRAF1 TRAF2 TRIM23 TRIM41 TSG101 UBE2D1 UBE2D2 UBE2D3 UBE2H UBE2K UBE2U UBE2Z UBOX5 UIMC1 USP2	5 interacting genes: PCNA RAD18 REV1 TRAIP WRN
Entrez ID		10293	51426
HPRD ID		05811	09291
Ensembl ID		ENSG00000183763	ENSG00000122008
Uniprot IDs		Q9BWF2	Q9UBT6
PDB IDs		4ZTD	1T94 2LSI 2OH2 2W7O 2W7P 3IN5 3PZP 4BA9 4GK5 4U6P 4U7C 5T14 5W2A 5W2C 6BRX 6BS1 6CST 7NV0 7NV1
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Ubiquitin Conjugating Enzyme Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Ubiquitin Protein Ligase Activity Proteolysis Involved In Protein Catabolic Process Proteolysis Protein K48-linked Ubiquitination Macromolecule Catabolic Process Protein Metabolic Process Transferase Activity Ubiquitin Protein Ligase Binding Macromolecule Metabolic Process Protein Autoubiquitination Tumor Necrosis Factor Receptor Superfamily Complex Catabolic Process Protein K11-linked Ubiquitination Microtubule End Tumor Necrosis Factor Binding Cell Death Programmed Cell Death Cytoplasmic Microtubule Thioesterase Binding Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Regulation Of Cytokine-mediated Signaling Pathway Protein Localization To Microtubule Positive Regulation Of Membrane Protein Ectodomain Proteolysis Ubiquitin-ubiquitin Ligase Activity Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Type I Interferon-mediated Signaling Pathway Nucleus Protein Catabolic Process Apoptotic Process Programmed Necrotic Cell Death Microtubule Plus-end Binding Protein Serine/threonine Kinase Binding Nucleoplasm Microtubule Plus-end	Replication Fork DNA Repair Replication Fork Processing DNA Metabolic Process DNA Synthesis Involved In DNA Repair Postreplication Repair DNA Damage Response Y-form DNA Binding Damaged DNA Binding DNA Biosynthetic Process MutLalpha Complex Binding Telomere Maintenance Via Semi-conservative Replication Cellular Response To Stress DNA Replication Response To UV Translesion Synthesis Nucleic Acid Metabolic Process Mismatch Repair Response To Light Stimulus Nucleobase-containing Compound Metabolic Process Protein-containing Complex Binding Response To Radiation Response To Stress PCNA Complex Replisome Positive Regulation Of Strand Invasion 3'-flap-structured DNA Binding Deoxycytidyl Transferase Activity Rad6-Rad18 Complex Telomere Maintenance PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Centrosome Telomere Organization Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Forked DNA-dependent Helicase Activity Chromosome Nucleoplasm Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Cellular Response To Radiation DNA Binding Chromosome, Telomeric Region Positive Regulation Of Deoxyribonuclease Activity Leading Strand Elongation Telomeric D-loop Binding Catalytic Activity, Acting On DNA Nucleobase-containing Compound Biosynthetic Process
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