TRAIP

Name	TRAF interacting protein
Structure
Interactors	29 interactors: ALOX15B APP CEP19 CYLD FLII LXN MAGEF1 MAPRE2 MAPRE3 POLK POLR1C RNF114 RNF4 TNFRSF1B TRAF1 TRAF2 TRIM23 TRIM41 TSG101 UBE2D1 UBE2D2 UBE2D3 UBE2H UBE2K UBE2U UBE2Z UBOX5 UIMC1 USP2
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Perinuclear Region Of Cytoplasm Site Of DNA Damage
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	DNA Repair Apoptotic Process DNA Damage Response Signal Transduction Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Ubiquitination Replication Fork Processing Negative Regulation Of Interferon-beta Production Protein-DNA Covalent Cross-linking Repair
Pathways	Antigen processing: Ubiquitination & Proteasome degradation
GWAS	Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) C-reactive protein levels ( 30388399 ) Cortical surface area (MOSTest) ( 32665545 ) Extremely high intelligence ( 29520040 ) Fasting insulin ( 34059833 ) Household income (MTAG) ( 31844048 ) Intelligence (MTAG) ( 29326435 ) Mental health study participation (provided email address) ( 31263887 ) Multisite chronic pain ( 33830993 ) Refractive error ( 32231278 ) Regular attendance at a gym or sports club ( 29970889 ) Regular attendance at a religious group ( 29970889 ) Sleep duration (short sleep) ( 30846698 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Tea consumption ( 31046077 ) Walking pace ( 33128006 )
Entrez ID	10293
HPRD ID	05811
Ensembl ID	ENSG00000183763
Uniprot IDs	Q9BWF2
PDB IDs	4ZTD
GO Terms Enriched among Interactors ?	Post-translational Protein Modification Ubiquitin Conjugating Enzyme Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Ubiquitin Protein Ligase Activity Proteolysis Involved In Protein Catabolic Process Proteolysis Protein K48-linked Ubiquitination Macromolecule Catabolic Process Protein Metabolic Process Transferase Activity Ubiquitin Protein Ligase Binding Macromolecule Metabolic Process Protein Autoubiquitination Tumor Necrosis Factor Receptor Superfamily Complex Catabolic Process Protein K11-linked Ubiquitination Microtubule End Tumor Necrosis Factor Binding Cell Death Programmed Cell Death Cytoplasmic Microtubule Thioesterase Binding Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Regulation Of Cytokine-mediated Signaling Pathway Protein Localization To Microtubule Positive Regulation Of Membrane Protein Ectodomain Proteolysis Ubiquitin-ubiquitin Ligase Activity Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Type I Interferon-mediated Signaling Pathway Nucleus Protein Catabolic Process Apoptotic Process Programmed Necrotic Cell Death Microtubule Plus-end Binding Protein Serine/threonine Kinase Binding Nucleoplasm Microtubule Plus-end