TRAIP and UBOX5

Number of citations of the paper that reports this interaction (PubMedID 22493164)
44

Data Source:
BioGRID (two hybrid)

		TRAIP	UBOX5
Description		TRAF interacting protein	U-box domain containing 5
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Perinuclear Region Of Cytoplasm Site Of DNA Damage	Nucleus Nucleoplasm Focal Adhesion Nuclear Body
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin-ubiquitin Ligase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	DNA Repair Apoptotic Process DNA Damage Response Signal Transduction Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Ubiquitination Replication Fork Processing Negative Regulation Of Interferon-beta Production Protein-DNA Covalent Cross-linking Repair	Protein Polyubiquitination Protein Ubiquitination
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels ( 30388399) Cortical surface area (MOSTest) ( 32665545) Extremely high intelligence ( 29520040) Fasting insulin ( 34059833) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Mental health study participation (provided email address) ( 31263887) Multisite chronic pain ( 33830993) Refractive error ( 32231278) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Tea consumption ( 31046077) Walking pace ( 33128006)	Household income ( 31844048) Household income (MTAG) ( 31844048) Night sleep phenotypes ( 27126917)
Interacting Genes		29 interacting genes: ALOX15B APP CEP19 CYLD FLII LXN MAGEF1 MAPRE2 MAPRE3 POLK POLR1C RNF114 RNF4 TNFRSF1B TRAF1 TRAF2 TRIM23 TRIM41 TSG101 UBE2D1 UBE2D2 UBE2D3 UBE2H UBE2K UBE2U UBE2Z UBOX5 UIMC1 USP2	19 interacting genes: MLH1 NEDD4 TRAF6 TRAIP TRIM23 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2K UBE2L3 UBE2V1 UBE2W USP2 VCP
Entrez ID		10293	22888
HPRD ID		05811	15605
Ensembl ID		ENSG00000183763	ENSG00000185019
Uniprot IDs		Q9BWF2	O94941
PDB IDs		4ZTD
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Ubiquitin Conjugating Enzyme Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Ubiquitin Protein Ligase Activity Proteolysis Involved In Protein Catabolic Process Proteolysis Protein K48-linked Ubiquitination Macromolecule Catabolic Process Protein Metabolic Process Transferase Activity Ubiquitin Protein Ligase Binding Macromolecule Metabolic Process Protein Autoubiquitination Tumor Necrosis Factor Receptor Superfamily Complex Catabolic Process Protein K11-linked Ubiquitination Microtubule End Tumor Necrosis Factor Binding Cell Death Programmed Cell Death Cytoplasmic Microtubule Thioesterase Binding Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Regulation Of Cytokine-mediated Signaling Pathway Protein Localization To Microtubule Positive Regulation Of Membrane Protein Ectodomain Proteolysis Ubiquitin-ubiquitin Ligase Activity Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Type I Interferon-mediated Signaling Pathway Nucleus Protein Catabolic Process Apoptotic Process Programmed Necrotic Cell Death Microtubule Plus-end Binding Protein Serine/threonine Kinase Binding Nucleoplasm Microtubule Plus-end	Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Post-translational Protein Modification Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Modification Process Protein K11-linked Ubiquitination Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Transferase Activity Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Monoubiquitination Macromolecule Metabolic Process Nucleotide Binding Macromolecule Catabolic Process ATP Binding Protein K63-linked Ubiquitination Proteolysis Nucleus DNA Damage Response Ubiquitin Protein Ligase Activity Catabolic Process Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Ubiquitination Regulation Of Post-translational Protein Modification Ubiquitin Ligase Complex ISG15 Transferase Activity DNA Repair Positive Regulation Of Protein Metabolic Process Ubiquitin Protein Ligase Binding ISG15-protein Conjugation Cellular Response To Stress Nucleoplasm Protein-DNA Covalent Cross-linking Repair Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Protein Modification Process Negative Regulation Of Biosynthetic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Protein Autoubiquitination Cellular Response To Misfolded Protein Response To Misfolded Protein DNA Metabolic Process Regulation Of Metabolic Process Protein-containing Complex Ubiquitin-ubiquitin Ligase Activity
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