BET1 and CRB3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		BET1	CRB3
Description		Bet1 golgi vesicular membrane trafficking protein	crumbs cell polarity complex component 3
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GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cis-Golgi Network Membrane Transport Vesicle SNARE Complex Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Plasma Membrane Bicellular Tight Junction Membrane Apical Plasma Membrane Cell Junction Protein-containing Complex Subapical Complex Apical Junction Complex Apical Part Of Cell Extracellular Exosome Anchoring Junction
	Molecular Function	SNAP Receptor Activity Protein Binding	Protein Binding SH3 Domain Binding Protein Domain Specific Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport Vesicle Fusion With Golgi Apparatus	Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Localization To Plasma Membrane Positive Regulation Of Cell Junction Assembly
Pathways		COPII-mediated vesicle transport COPI-mediated anterograde transport	Tight junction interactions SARS-CoV-2 targets PDZ proteins in cell-cell junction
Drugs
Diseases
GWAS		Aging ( 22773346) Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 25987655) BRCA1/2-negative high-risk breast cancer ( 30323354) Obesity-related traits ( 23251661) World class endurance athleticism ( 26824906)
Interacting Genes		57 interacting genes: ADORA2A ANKS6 AQP6 ASGR2 ASZ1 BCL2L13 BIK CD74 CD79A CGRRF1 CISD2 CLDN7 CLEC10A CRB3 CREB3L1 CYB561 CYB5R3 CYBC1 ELOVL4 ERGIC3 FAM174A FAM209A FAM210B FAM9B FKBP7 GPR152 GPX8 JAGN1 KASH5 KCNJ6 LYPD5 MAGEA6 MFF MGST3 NAPB PTGES REEP4 RETREG3 SAR1A SLC26A6 SLC35H1 SLC7A14 SNCA SNTG2 SSMEM1 STX1A STX1B STX2 STX4 STX5 TMCO5A TMEM237 TMEM35A TMEM52B TMEM80 TMX2 USHBP1	28 interacting genes: ANKRD46 BCL2L13 BET1 FUNDC2 HMOX1 HMOX2 NDUFA3 PALS1 PARD6A PATJ PLLP PLP2 PSENEN PSMA3 RABAC1 SERF1A SERF1B SERP1 SLC39A9 STX5 TECR TMEM222 TREX1 UBIAD1 VAMP1 VTI1B WDR83 YIPF6
Entrez ID		10282	92359
HPRD ID		16107	16749
Ensembl ID		ENSG00000105829	ENSG00000130545
Uniprot IDs		O15155 Q53XK0	Q9BUF7
PDB IDs		3EGX	5I7Z
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane SNARE Binding SNAP Receptor Activity Positive Regulation Of Neurotransmitter Secretion Protein Binding SNARE Complex Endoplasmic Reticulum Vesicle Docking Regulation Of Synaptic Vesicle Priming Organelle Localization By Membrane Tethering SNARE Complex Assembly Membrane Docking Vesicle Fusion Organelle Membrane Fusion Glutathione Peroxidase Activity Exocytosis Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Mitochondrial Outer Membrane Organelle Fusion Presynaptic Active Zone Membrane Vesicle-mediated Transport Positive Regulation Of Synaptic Transmission Cornified Envelope Assembly Membrane Fusion Synaptic Vesicle Exocytosis Regulation Of Neurotransmitter Secretion Fucose Binding Prostanoid Metabolic Process Endomembrane System Unsaturated Fatty Acid Metabolic Process Regulation Of Catecholamine Secretion Secretion Neurotransmitter Transport Unsaturated Fatty Acid Biosynthetic Process Response To Type II Interferon Secretion By Cell Mitochondrial Membrane Icosanoid Biosynthetic Process Intracellular Protein Transport Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Positive Regulation Of Secretion By Cell Vesicle Fusion To Plasma Membrane Regulation Of Norepinephrine Secretion Vesicle Organization Synaptic Vesicle Docking Positive Regulation Of Secretion Organelle Localization Membrane Assembly Synaptic Transmission, Dopaminergic	Endoplasmic Reticulum Membrane SNAP Receptor Activity Membrane SNARE Complex Heme Oxidation Heme Oxygenase (decyclizing) Activity Vesicle Fusion Organelle Membrane Fusion Golgi Apparatus Endomembrane System Organelle Fusion Vesicle Fusion With Golgi Apparatus Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Endoplasmic Reticulum Establishment Or Maintenance Of Apical/basal Cell Polarity Heme Catabolic Process Membrane Fusion Porphyrin-containing Compound Catabolic Process Myelin Assembly Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Membrane Organization Golgi Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Vesicle Transport Amyloid Fibril Formation Apical Junction Complex Bicellular Tight Junction Protein Binding Autophagy Heme Metabolic Process Vesicle Organization Immune Complex Formation Adenyl Deoxyribonucleotide Binding Immune Response In Brain Or Nervous System Vitamin K Biosynthetic Process Menaquinone Biosynthetic Process Protein Localization To Myelin Sheath Abaxonal Region Tight Junction Porphyrin-containing Compound Metabolic Process Macroautophagy Establishment Or Maintenance Of Cell Polarity
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