BET1 and CD74

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		BET1	CD74
Description		Bet1 golgi vesicular membrane trafficking protein	CD74 molecule
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GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cis-Golgi Network Membrane Transport Vesicle SNARE Complex Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Golgi Membrane Extracellular Region Nucleus Cytoplasm Lysosome Lysosomal Membrane Endosome Late Endosome Multivesicular Body Vacuole Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane Protein-containing Complex Macrophage Migration Inhibitory Factor Receptor Complex NOS2-CD74 Complex MHC Class II Protein Complex Lysosomal Lumen Extracellular Exosome Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	SNAP Receptor Activity Protein Binding	Amyloid-beta Binding Cytokine Receptor Activity Protein Binding Cytokine Binding MHC Class II Protein Complex Binding Macrophage Migration Inhibitory Factor Binding MHC Class II Protein Binding CD4 Receptor Binding MHC Class II Protein Binding, Via Antigen Binding Groove Identical Protein Binding Protein Folding Chaperone Nitric-oxide Synthase Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport Vesicle Fusion With Golgi Apparatus	Prostaglandin Biosynthetic Process Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cytokine-mediated Signaling Pathway Adaptive Immune Response T Cell Activation Involved In Immune Response Immune System Process Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Negative Regulation Of Peptide Secretion Positive Regulation Of Type 2 Immune Response Negative Regulation Of Mature B Cell Apoptotic Process Protein Folding Intracellular Protein Transport Defense Response Immune Response Positive Regulation Of Gene Expression Immunoglobulin Mediated Immune Response Antigen Processing And Presentation Antigen Processing And Presentation Of Endogenous Antigen Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Cell Migration Positive Regulation Of B Cell Proliferation Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Kinase Activity Response To Type II Interferon Macrophage Migration Inhibitory Factor Signaling Pathway Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator T Cell Selection Positive Thymic T Cell Selection Negative Thymic T Cell Selection Negative Regulation Of T Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of Monocyte Differentiation Positive Regulation Of DNA-templated Transcription Host-mediated Suppression Of Symbiont Invasion Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of Fibroblast Proliferation Protein Stabilization Positive Regulation Of Macrophage Cytokine Production Protein-containing Complex Assembly Protein Trimerization Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Neutrophil Chemotaxis Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway
Pathways		COPII-mediated vesicle transport COPI-mediated anterograde transport	Cell surface interactions at the vascular wall MHC class II antigen presentation Developmental Lineage of Pancreatic Ductal Cells
Drugs
Diseases
GWAS		Aging ( 22773346) Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 25987655) BRCA1/2-negative high-risk breast cancer ( 30323354) Obesity-related traits ( 23251661) World class endurance athleticism ( 26824906)	Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		57 interacting genes: ADORA2A ANKS6 AQP6 ASGR2 ASZ1 BCL2L13 BIK CD74 CD79A CGRRF1 CISD2 CLDN7 CLEC10A CRB3 CREB3L1 CYB561 CYB5R3 CYBC1 ELOVL4 ERGIC3 FAM174A FAM209A FAM210B FAM9B FKBP7 GPR152 GPX8 JAGN1 KASH5 KCNJ6 LYPD5 MAGEA6 MFF MGST3 NAPB PTGES REEP4 RETREG3 SAR1A SLC26A6 SLC35H1 SLC7A14 SNCA SNTG2 SSMEM1 STX1A STX1B STX2 STX4 STX5 TMCO5A TMEM237 TMEM35A TMEM52B TMEM80 TMX2 USHBP1	45 interacting genes: APP BET1 C14orf180 CCR1 CD1D CD44 CLDN19 CLEC7A CMTM7 CTSF CTSL DSCR9 EDDM3B ERG28 FDFT1 FXYD6 HADHA HLA-DMA HLA-DMB HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRA LAMTOR5 LPAR3 MAP3K1 MIF PGA4 PLP1 PLPP4 POMGNT1 PTCH1 RTP2 SEC22A SERP1 SLC35B1 SMIM1 TEX11 TMEM120B TMEM243 TMEM254 TMEM60 TMEM97 UPK2
Entrez ID		10282	972
HPRD ID		16107	00825
Ensembl ID		ENSG00000105829	ENSG00000019582
Uniprot IDs		O15155 Q53XK0	P04233
PDB IDs		3EGX	1A6A 1ICF 1IIE 1L3H 1MUJ 3PDO 3PGC 3PGD 3QXA 3QXD 4AEN 4AH2 4X5W 5KSU 5KSV 7YX9 7YXB 7Z0Q 8VRW 8VSJ 8VSP 9CYL 9CYM
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane SNARE Binding SNAP Receptor Activity Positive Regulation Of Neurotransmitter Secretion Protein Binding SNARE Complex Endoplasmic Reticulum Vesicle Docking Regulation Of Synaptic Vesicle Priming Organelle Localization By Membrane Tethering SNARE Complex Assembly Membrane Docking Vesicle Fusion Organelle Membrane Fusion Glutathione Peroxidase Activity Exocytosis Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Mitochondrial Outer Membrane Organelle Fusion Presynaptic Active Zone Membrane Vesicle-mediated Transport Positive Regulation Of Synaptic Transmission Cornified Envelope Assembly Membrane Fusion Synaptic Vesicle Exocytosis Regulation Of Neurotransmitter Secretion Fucose Binding Prostanoid Metabolic Process Endomembrane System Unsaturated Fatty Acid Metabolic Process Regulation Of Catecholamine Secretion Secretion Neurotransmitter Transport Unsaturated Fatty Acid Biosynthetic Process Response To Type II Interferon Secretion By Cell Mitochondrial Membrane Icosanoid Biosynthetic Process Intracellular Protein Transport Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Positive Regulation Of Secretion By Cell Vesicle Fusion To Plasma Membrane Regulation Of Norepinephrine Secretion Vesicle Organization Synaptic Vesicle Docking Positive Regulation Of Secretion Organelle Localization Membrane Assembly Synaptic Transmission, Dopaminergic	Antigen Processing And Presentation Of Exogenous Antigen Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Exogenous Peptide Antigen Peptide Antigen Assembly With MHC Class II Protein Complex MHC Class II Protein Complex Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation MHC Class II Protein Complex Binding Peptide Antigen Binding Lysosome Positive Regulation Of Cell Activation MHC Class II Receptor Activity Late Endosome Membrane Membrane Positive Regulation Of Lymphocyte Activation Lumenal Side Of Endoplasmic Reticulum Membrane Endocytic Vesicle Membrane Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Transport Vesicle Membrane Positive Regulation Of T Cell Activation Trans-Golgi Network Membrane Lysosomal Membrane ER To Golgi Transport Vesicle Membrane Regulation Of Leukocyte Cell-cell Adhesion Cell Surface Regulation Of Cell Activation Regulation Of Lymphocyte Activation Adaptive Immune Response Clathrin-coated Endocytic Vesicle Membrane Positive Regulation Of Immune System Process Immune System Process Endoplasmic Reticulum Regulation Of Immune Response Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Positive Regulation Of Immune Response Regulation Of T Cell Activation Immune Response Endoplasmic Reticulum Membrane Positive Regulation Of Multicellular Organismal Process Regulation Of Immune System Process Positive Regulation Of Type II Interferon Production Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Leukocyte Proliferation Plasma Membrane Endosome
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