BET1 and ASGR2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		BET1	ASGR2
Description		Bet1 golgi vesicular membrane trafficking protein	asialoglycoprotein receptor 2
Image
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cis-Golgi Network Membrane Transport Vesicle SNARE Complex Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Plasma Membrane External Side Of Plasma Membrane Membrane Endoplasmic Reticulum Quality Control Compartment Perinuclear Region Of Cytoplasm
	Molecular Function	SNAP Receptor Activity Protein Binding	Asialoglycoprotein Receptor Activity Protein Binding D-mannose Binding Carbohydrate Binding Pattern Recognition Receptor Activity Fucose Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport Vesicle Fusion With Golgi Apparatus	Endocytosis Immune Response Cell Surface Receptor Signaling Pathway
Pathways		COPII-mediated vesicle transport COPI-mediated anterograde transport	Asparagine N-linked glycosylation
Drugs			Antihemophilic factor, human recombinant Lonoctocog alfa Moroctocog alfa
Diseases
GWAS		Aging ( 22773346) Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 25987655) BRCA1/2-negative high-risk breast cancer ( 30323354) Obesity-related traits ( 23251661) World class endurance athleticism ( 26824906)	Congenital heart disease (maternal effect) ( 28468790) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Liver enzyme levels (alkaline phosphatase) ( 33972514) Total cholesterol levels ( 30275531)
Interacting Genes		57 interacting genes: ADORA2A ANKS6 AQP6 ASGR2 ASZ1 BCL2L13 BIK CD74 CD79A CGRRF1 CISD2 CLDN7 CLEC10A CRB3 CREB3L1 CYB561 CYB5R3 CYBC1 ELOVL4 ERGIC3 FAM174A FAM209A FAM210B FAM9B FKBP7 GPR152 GPX8 JAGN1 KASH5 KCNJ6 LYPD5 MAGEA6 MFF MGST3 NAPB PTGES REEP4 RETREG3 SAR1A SLC26A6 SLC35H1 SLC7A14 SNCA SNTG2 SSMEM1 STX1A STX1B STX2 STX4 STX5 TMCO5A TMEM237 TMEM35A TMEM52B TMEM80 TMX2 USHBP1	50 interacting genes: ADAM33 ADIPOQ AIG1 ASGR1 ATP6V0C BET1 CD53 CERS2 CLEC17A CLEC7A EMP1 F8 FA2H FATE1 GLP1R GLUD1 HES1 HMOX2 IL1RL1 LAT LNPEP MCEMP1 MMD2 MROH5 MS4A13 NRG1 ORMDL1 PLN PLP2 PMP22 RPRM SEC22A SLC35A1 SLC35B2 SMIM3 SNCA STX8 TFRC TMEM140 TMEM60 TMEM86B TMPPE TRAM1L1 TSPO2 UBIAD1 UPK2 VAMP5 VKORC1 VTI1B YIPF1
Entrez ID		10282	433
HPRD ID		16107	00152
Ensembl ID		ENSG00000105829	ENSG00000161944
Uniprot IDs		O15155 Q53XK0	P07307 Q7Z4G9
PDB IDs		3EGX	8URF
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane SNARE Binding SNAP Receptor Activity Positive Regulation Of Neurotransmitter Secretion Protein Binding SNARE Complex Endoplasmic Reticulum Vesicle Docking Regulation Of Synaptic Vesicle Priming Organelle Localization By Membrane Tethering SNARE Complex Assembly Membrane Docking Vesicle Fusion Organelle Membrane Fusion Glutathione Peroxidase Activity Exocytosis Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Mitochondrial Outer Membrane Organelle Fusion Presynaptic Active Zone Membrane Vesicle-mediated Transport Positive Regulation Of Synaptic Transmission Cornified Envelope Assembly Membrane Fusion Synaptic Vesicle Exocytosis Regulation Of Neurotransmitter Secretion Fucose Binding Prostanoid Metabolic Process Endomembrane System Unsaturated Fatty Acid Metabolic Process Regulation Of Catecholamine Secretion Secretion Neurotransmitter Transport Unsaturated Fatty Acid Biosynthetic Process Response To Type II Interferon Secretion By Cell Mitochondrial Membrane Icosanoid Biosynthetic Process Intracellular Protein Transport Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Positive Regulation Of Secretion By Cell Vesicle Fusion To Plasma Membrane Regulation Of Norepinephrine Secretion Vesicle Organization Synaptic Vesicle Docking Positive Regulation Of Secretion Organelle Localization Membrane Assembly Synaptic Transmission, Dopaminergic	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum SNAP Receptor Activity Protein Binding Regulation Of Mitotic Cell Cycle, Embryonic Pancreas Development Fucose Binding Regulation Of Secondary Heart Field Cardioblast Proliferation Endomembrane System Chloride Channel Inhibitor Activity Vesicle Fusion With Golgi Apparatus Plasma Membrane Pattern Recognition Receptor Activity Perinuclear Region Of Cytoplasm Regulation Of Calcium Ion Import Negative Regulation Of Gliogenesis Regulation Of Cardioblast Proliferation Bleb Assembly Positive Regulation Of Phosphate Metabolic Process SNARE Complex Organelle Membrane Identical Protein Binding Nephron Tubule Formation Negative Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Protein Kinase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Protein Autophosphorylation Nephron Tubule Morphogenesis Cellular Response To Epinephrine Stimulus Vitamin K Metabolic Process Kidney Morphogenesis Positive Regulation Of Kinase Activity Negative Regulation Of Calcium Ion Import Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Monocyte Chemotactic Protein-1 Production
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