TPX2 and NAP1L1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		TPX2	NAP1L1
Gene Name		TPX2, microtubule-associated	nucleosome assembly protein 1-like 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Cytoplasm Spindle Microtubule Microtubule Cytoskeleton Axon Hillock	Nucleus Membrane Melanosome
	Molecular Function	Protein Binding ATP Binding GTP Binding Protein Kinase Binding	Protein Binding Poly(A) RNA Binding
	Biological Process	Apoptotic Process Mitotic Nuclear Division Cell Proliferation Activation Of Protein Kinase Activity Cell Division Regulation Of Mitotic Spindle Organization	DNA Replication Nucleosome Assembly Positive Regulation Of Cell Proliferation
Pathways
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		7 interactors: AURKA CDK6 GOLGA2 HMMR NAP1L1 SIAH2 THAP11	14 interactors: CREBBP CSNK2B DLST EP300 FSD1 HBA1 MED10 NR2F6 PHB POT1 SP1 TERF1 TP53 TPX2
Entrez ID		22974	4673
HPRD ID		05802	01248
Ensembl ID		ENSG00000088325	ENSG00000187109
Uniprot IDs		Q643R0 Q96RR5 Q9ULW0	B3KV44 B7Z4K9 B7Z9C2 F8W543 P55209
PDB IDs		1OL5 3E5A 3HA6
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Protein Binding Negative Regulation Of Spindle Checkpoint Cell Dedifferentiation Cell Cycle Negative Regulation Of Binding Spindle Assembly Involved In Female Meiosis I Regulation Of Protein Binding Spindle Assembly Involved In Meiosis Mitotic Cell Cycle Spindle Stabilization Positive Regulation Of Oocyte Maturation Regulation Of Binding Mitotic Cell Cycle Phase Transition Meiotic Spindle Organization Cell Cycle Phase Transition Protein Localization To Centrosome Mitotic Centrosome Separation Negative Regulation Of Cellular Senescence Female Meiosis I Positive Regulation Of Oocyte Development Centrosome Separation Hematopoietic Stem Cell Differentiation Hyaluronan Catabolic Process Negative Regulation Of Cell Aging Dentate Gyrus Development Protein Localization To Cytoskeleton Histone-serine Phosphorylation Type B Pancreatic Cell Development	N-terminal Peptidyl-lysine Acetylation Mitotic Cell Cycle Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of DNA Replication Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomerase Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Positive Regulation Of Macromolecule Biosynthetic Process Chromosome Organization Positive Regulation Of Cellular Biosynthetic Process Positive Regulation By Host Of Viral Transcription Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Negative Regulation Of Telomerase Activity Regulation Of Telomere Maintenance Via Telomerase N-terminal Protein Amino Acid Acetylation Negative Regulation Of DNA Metabolic Process Rhythmic Process Cellular Response To Hypoxia Positive Regulation Of Metabolic Process Cellular Response To Decreased Oxygen Levels Mitotic Cell Cycle Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Telomerase Activity Cellular Response To Oxygen Levels Chromatin Organization Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of DNA Replication Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Telomere Maintenance Positive Regulation Of Transcription, DNA-templated Cell Cycle Regulation Of Androgen Receptor Signaling Pathway Notch Signaling Pathway Cellular Nitrogen Compound Metabolic Process RNA-dependent DNA Replication Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Cellular Metabolic Process Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of DNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Photoperiodism Entrainment Of Circadian Clock N-terminal Protein Amino Acid Modification Organelle Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Gene Expression
Tagcloud ?		actively autonomous clustering connected connectivity conserved degree displaying disseminated distant dormant enhances enriched etiology histologic identification inferred instead metastasis metastatic modules network networks proliferating tool transition utilized validate variation	arrays asf1a assembles assembly breaks caf chaperones clamp coupled elucidating faithfully h2a h2b loader nascent nucleosomal nucleosome nucleosomes p48 packaging pcna progress recapitulates replication replicative reproduces rfc strand synthesized
Tagcloud (Difference) ?		actively autonomous clustering connected connectivity conserved degree displaying disseminated distant dormant enhances enriched etiology histologic identification inferred instead metastasis metastatic modules network networks proliferating tool transition utilized validate variation	arrays asf1a assembles assembly breaks caf chaperones clamp coupled elucidating faithfully h2a h2b loader nascent nucleosomal nucleosome nucleosomes p48 packaging pcna progress recapitulates replication replicative reproduces rfc strand synthesized
Tagcloud (Intersection) ?