TPX2 and THAP11

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		TPX2	THAP11
Description		TPX2 microtubule nucleation factor	THAP domain containing 11
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GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Cytoplasm Spindle Cytosol Cytoskeleton Microtubule Microtubule Cytoskeleton Axon Hillock Intercellular Bridge Mitotic Spindle	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Activator Activity Molecular Adaptor Activity Importin-alpha Family Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Mitotic Cell Cycle Apoptotic Process Microtubule Nucleation Negative Regulation Of Microtubule Depolymerization Activation Of Protein Kinase Activity Cell Division Regulation Of Mitotic Spindle Organization Mitotic Spindle Assembly	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cell Population Proliferation Electron Transport Chain Neuron Differentiation Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Mitochondrial Transcription
Pathways		Regulation of TP53 Activity through Phosphorylation AURKA Activation by TPX2
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Immature fraction of reticulocytes ( 32888494) Mean reticulocyte volume ( 32888494) Monocyte percentage of white cells ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070) Prudent dietary pattern ( 28644415)	Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 27863252) Schizophrenia ( 25056061 29483656)
Interacting Genes		12 interacting genes: AURKA CDK6 CEBPA GOLGA2 HMMR KPNA4 NAP1L1 RNF10 SIAH2 SUMO2 THAP11 USP7	21 interacting genes: BBLN CASP3 CEBPA CFTR ECT2 HCFC1 HDAC1 HDAC3 HEMGN L3MBTL2 LRRC45 MCPH1 NUTF2 PFDN6 PSMC5 SIN3A SLX1B SRSF11 THAP7 TPX2 VPS52
Entrez ID		22974	57215
HPRD ID		05802	11629
Ensembl ID		ENSG00000088325	ENSG00000168286
Uniprot IDs		Q643R0 Q9ULW0	Q96EK4
PDB IDs		1OL5 3E5A 3HA6 4C3P 5LXM 6BJC 6VPG 6VPH 6VPI 6VPJ 6VPL 6VPM 6XKA	2LAU 5AJS
Enriched GO Terms of Interacting Partners?		Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Meiotic Spindle Assembly Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteolysis Meiotic Spindle Organization Macromolecule Metabolic Process Regulation Of Cell Development Negative Regulation Of Protein Binding Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Protein Modification Process Regulation Of Protein Binding Positive Regulation Of Catabolic Process Centrosome Cycle Positive Regulation Of Metabolic Process Cyclin D2-CDK6 Complex Animal Organ Regeneration RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Cell Development Regulation Of Macromolecule Biosynthetic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding Response To Vitamin B2 C/EBP Complex Organelle Disassembly Nucleus Nucleoplasm Microtubule Organizing Center Organization Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Biosynthetic Process Notch Signaling Pathway Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Differentiation Positive Regulation Of Protein Metabolic Process CHOP-C/EBP Complex	Nucleoplasm Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Binding Negative Regulation Of RNA Biosynthetic Process Protein Decrotonylase Activity Histone Decrotonylase Activity Protein Lysine Delactylase Activity Negative Regulation Of Metabolic Process Regulation Of Cell Cycle Negative Regulation Of RNA Metabolic Process Chromatin Binding Histone Deacetylase Binding Histone Deacetylase Complex Transcription Corepressor Binding Transcription Repressor Complex Histone Deacetylase Activity, Hydrolytic Mechanism Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Protein Deacetylation Protein Lysine Deacetylase Activity General Transcription Initiation Factor Binding Response To Ketone Negative Regulation Of Biosynthetic Process Chromatin DNA Binding Rhythmic Process Protein-containing Complex Negative Regulation Of Myotube Differentiation Histone Deacetylase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Primary Metabolic Process Nucleus Sin3-type Complex Chromatin Organization Negative Regulation Of Stem Cell Population Maintenance Macromolecule Deacylation Microtubule Cytoskeleton Organization Involved In Mitosis Response To Glucocorticoid Mitotic Spindle Heterochromatin Formation NF-kappaB Binding Cellular Developmental Process Regulation Of Protein Stability Regulation Of Macromolecule Metabolic Process Cell Differentiation Response To Corticosteroid RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity
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