TPX2 and THAP11

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		TPX2	THAP11
Gene Name		TPX2, microtubule-associated	THAP domain containing 11
Image
Gene Ontology Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Cytoplasm Spindle Microtubule Microtubule Cytoskeleton Axon Hillock	Nucleoplasm Cytoplasm Intercellular Bridge
	Molecular Function	Protein Binding ATP Binding GTP Binding Protein Kinase Binding	DNA Binding Protein Binding Zinc Ion Binding
	Biological Process	Apoptotic Process Mitotic Nuclear Division Cell Proliferation Activation Of Protein Kinase Activity Cell Division Regulation Of Mitotic Spindle Organization	Transcription, DNA-templated Regulation Of Transcription, DNA-templated
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: AURKA CDK6 GOLGA2 HMMR NAP1L1 SIAH2 THAP11	16 interactors: C9orf16 CASP3 CTBP1 ECT2 HCFC1 HDAC1 HDAC3 LRRC45 PFDN6 PSMC5 SIN3A SLX1B SRSF11 THAP7 TPX2 VPS52
Entrez ID		22974	57215
HPRD ID		05802	11629
Ensembl ID		ENSG00000088325	ENSG00000168286
Uniprot IDs		Q643R0 Q96RR5 Q9ULW0	Q96EK4
PDB IDs		1OL5 3E5A 3HA6	2LAU
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Protein Binding Negative Regulation Of Spindle Checkpoint Cell Dedifferentiation Cell Cycle Negative Regulation Of Binding Spindle Assembly Involved In Female Meiosis I Regulation Of Protein Binding Spindle Assembly Involved In Meiosis Mitotic Cell Cycle Spindle Stabilization Positive Regulation Of Oocyte Maturation Regulation Of Binding Mitotic Cell Cycle Phase Transition Meiotic Spindle Organization Cell Cycle Phase Transition Protein Localization To Centrosome Mitotic Centrosome Separation Negative Regulation Of Cellular Senescence Female Meiosis I Positive Regulation Of Oocyte Development Centrosome Separation Hematopoietic Stem Cell Differentiation Hyaluronan Catabolic Process Negative Regulation Of Cell Aging Dentate Gyrus Development Protein Localization To Cytoskeleton Histone-serine Phosphorylation Type B Pancreatic Cell Development	Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone Modification Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Neurotrophin TRK Receptor Signaling Pathway Histone Deacetylation Transcription From RNA Polymerase II Promoter Neurotrophin Signaling Pathway Protein Deacetylation Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cell Cycle Chromatin Modification Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Chromatin Organization Positive Regulation Of Protein Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Histone Acetylation Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Peptidyl-lysine Acetylation Regulation Of Mitotic Cell Cycle Cell Cycle Negative Regulation Of Protein Acetylation Histone H4 Deacetylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cell Cycle Regulation Of Apoptotic Process Positive Regulation Of Protein Modification Process Negative Regulation Of Apoptotic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Cell Cycle Process Cellular Response To Stress Regulation Of Cell Death Histone H3 Deacetylation Cellular Response To Oxidative Stress Regulation Of Protein Localization To Nucleus Histone H3-K9 Modification Negative Regulation Of Cell Death RNA Metabolic Process
Tagcloud ?		actively autonomous clustering connected connectivity conserved degree displaying disseminated distant dormant enhances enriched etiology histologic identification inferred instead metastasis metastatic modules network networks proliferating tool transition utilized validate variation	blastocysts bts cdh3 cdx2 chir99021 continually cyp11a1 dome elf5 eomes ets2 feeders gcm1 gdf3 hand1 hsd17b1 mash2 nanog oct4 pd0325901 pparg smarca4 sox2 ssea tdk tead4 teratomas tfap2a tscs
Tagcloud (Difference) ?		actively autonomous clustering connected connectivity conserved degree displaying disseminated distant dormant enhances enriched etiology histologic identification inferred instead metastasis metastatic modules network networks proliferating tool transition utilized validate variation	blastocysts bts cdh3 cdx2 chir99021 continually cyp11a1 dome elf5 eomes ets2 feeders gcm1 gdf3 hand1 hsd17b1 mash2 nanog oct4 pd0325901 pparg smarca4 sox2 ssea tdk tead4 teratomas tfap2a tscs
Tagcloud (Intersection) ?