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PPARGC1A and ESRRA
Number of citations of the paper that reports this interaction (PubMedID
19462000
)
46
Data Source:
BioGRID
(pull down, affinity chromatography technology)
HPRD
(in vitro, two hybrid)
PPARGC1A
ESRRA
Description
PPARG coactivator 1 alpha
estrogen related receptor alpha
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
PML Body
Chromatin
Fibrillar Center
Nucleus
Nucleoplasm
Cytoplasm
Microtubule Cytoskeleton
Intercellular Bridge
Molecular Function
Nucleic Acid Binding
DNA Binding
Transcription Coregulator Activity
Transcription Coactivator Activity
RNA Binding
Protein Binding
Nuclear Receptor Binding
Chromatin DNA Binding
Ubiquitin Protein Ligase Binding
Sequence-specific DNA Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
LncRNA Binding
DNA-binding Transcription Factor Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Nuclear Steroid Receptor Activity
Nuclear Receptor Activity
Steroid Binding
Protein Binding
Zinc Ion Binding
Protein Domain Specific Binding
Estrogen Response Element Binding
Sequence-specific DNA Binding
Metal Ion Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Temperature Homeostasis
Intracellular Glucose Homeostasis
Response To Dietary Excess
Gluconeogenesis
Regulation Of DNA-templated Transcription
Transcription Initiation At RNA Polymerase II Promoter
MRNA Processing
Mitochondrion Organization
Digestion
RNA Splicing
Positive Regulation Of Gene Expression
Response To Muscle Activity
Fatty Acid Oxidation
Respiratory Electron Transport Chain
Developmental Process
Circadian Regulation Of Gene Expression
Cellular Response To Oxidative Stress
Homeostatic Process
Response To Starvation
Regulation Of Circadian Rhythm
Negative Regulation Of Neuron Apoptotic Process
Cellular Respiration
Positive Regulation Of Gluconeogenesis
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Fatty Acid Oxidation
Rhythmic Process
Negative Regulation Of Smooth Muscle Cell Proliferation
Protein Stabilization
Brown Fat Cell Differentiation
Neuron Apoptotic Process
Adipose Tissue Development
Protein-containing Complex Assembly
Energy Homeostasis
Positive Regulation Of Cold-induced Thermogenesis
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Nuclear Receptor-mediated Steroid Hormone Signaling Pathway
Intracellular Receptor Signaling Pathway
Positive Regulation Of Transcription By RNA Polymerase II
Pathways
PPARA activates gene expression
Transcriptional activation of mitochondrial biogenesis
Transcriptional activation of mitochondrial biogenesis
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
SUMOylation of transcription cofactors
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Heme signaling
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
Regulation of MITF-M dependent genes involved in metabolism
Expression of BMAL (ARNTL), CLOCK, and NPAS2
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
PPARA activates gene expression
Transcriptional activation of mitochondrial biogenesis
Transcriptional activation of mitochondrial biogenesis
Nuclear Receptor transcription pathway
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Drugs
Troglitazone
Diethylstilbestrol
Genistein
Afimoxifene
beta-Naphthoflavone
1-CYCLOHEXYL-N-{[1-(4-METHYLPHENYL)-1H-INDOL-3-YL]METHYL}METHANAMINE
Flavone
Diseases
GWAS
Aspartate aminotransferase levels (
33547301
)
Coffee consumption (
31046077
)
Cognitive decline rate in late mild cognitive impairment (
26252872
)
Corneal astigmatism (
29422769
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Essential tremor (
27797806
)
Estimated glomerular filtration rate (
31152163
31015462
)
Femur bone mineral density x serum urate levels interaction (
34046847
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Intralaminar thalamic nuclei volume (
34006833
)
Lead levels (
26025379
)
Molar-incisor hypomineralization (
23918034
)
PR interval (
32439900
)
Refractive error (
32231278
)
Resting heart rate (
27798624
)
Rosacea symptom severity (
29771307
)
Schizophrenia (
30285260
)
Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) (
31557306
)
Thiazide-induced adverse metabolic effects in hypertensive patients (
23400010
)
Crohn's disease (
21102463
28067908
)
Vitiligo (
27723757
)
Interacting Genes
44 interacting genes:
CAPNS1
CDK6
CREBBP
ESR1
ESR2
ESRRA
ESRRG
FBXW7
GSK3B
HCFC1
HNF4A
LRPPRC
MAPK14
MED1
MED12
MED14
MED17
MYBBP1A
NCL
NCOA1
NCOA6
NDN
NR1H4
NR1I2
NR1I3
NR3C1
NRF1
PPARA
PPARD
PPARG
RARB
RNF10
RXRA
SIRT1
SKP1
SRSF4
SRSF5
SRSF6
THRB
TP53
UBC
UBE2I
USF1
USF2
37 interacting genes:
ADH5
ATXN1
DUT
ESR1
ESRRG
EXOSC6
FAM9A
FUS
GTF2B
HDAC8
HIF1A
KAT2B
LYST
MACF1
MAP2K5
NCOA1
NCOA2
NCOA3
NR0B1
NR0B2
NRIP1
NSD1
NXF1
PIAS4
PNRC2
PPARG
PPARGC1A
PRKCD
PROX1
PSMC5
REL
RNF4
RXRA
SIRT1
SMARCD3
SP1
TNNI2
Entrez ID
10891
2101
HPRD ID
05155
07210
Ensembl ID
ENSG00000109819
ENSG00000173153
Uniprot IDs
D6RBF3
Q9UBK2
P11474
Q569H8
PDB IDs
1XB7
3B1M
3CS8
3D24
3U9Q
3V9T
3V9V
4QJR
4QK4
5Q0I
5TWO
5UNJ
5Z5S
5Z6S
6AD9
6FZF
6FZP
6IZM
6IZN
6K0T
6KXX
6KXY
6LN4
6MS7
6NWK
6NWL
6T1V
6W9K
6W9L
7E2E
7KHT
7PRV
7PRW
7PRX
8BF1
8DK4
9F7W
9F7X
1XB7
2PJL
3D24
3K6P
7E2E
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Transcription By RNA Polymerase II
Nuclear Receptor Activity
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Nucleoplasm
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Nuclear Receptor-mediated Signaling Pathway
Intracellular Receptor Signaling Pathway
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Metabolic Process
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of Primary Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Sequence-specific DNA Binding
Hormone-mediated Signaling Pathway
Nucleus
Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity
Chromatin
Negative Regulation Of Macromolecule Metabolic Process
Steroid Hormone Receptor Signaling Pathway
Nuclear Receptor-mediated Steroid Hormone Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Metabolic Process
Nuclear Steroid Receptor Activity
DNA Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Intracellular Signal Transduction
Rhythmic Process
Estrogen Response Element Binding
Transcription Coactivator Binding
Peroxisome Proliferator Activated Receptor Signaling Pathway
Nuclear Vitamin D Receptor Binding
Nuclear Receptor Binding
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Chromatin
Nucleoplasm
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Biosynthetic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Metabolic Process
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Rhythmic Process
Positive Regulation Of Metabolic Process
Transcription Coregulator Activity
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Nucleus
Negative Regulation Of RNA Metabolic Process
Nuclear Retinoid X Receptor Binding
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Primary Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Macromolecule Metabolic Process
Nuclear Receptor-mediated Signaling Pathway
Negative Regulation Of Macromolecule Biosynthetic Process
DNA-binding Transcription Factor Binding
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Transcription Coactivator Activity
Peroxisome Proliferator Activated Receptor Signaling Pathway
Regulation Of Metabolic Process
Positive Regulation Of Adipose Tissue Development
Negative Regulation Of Metabolic Process
Regulation Of Lipid Metabolic Process
Transcription Coregulator Binding
Nuclear Retinoic Acid Receptor Binding
DNA Binding Domain Binding
Regulation Of Adipose Tissue Development
Retinoic Acid Receptor Signaling Pathway
Transcription By RNA Polymerase II
Protein-lysine-acetyltransferase Activity
LBD Domain Binding
Circadian Regulation Of Gene Expression
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