PPARGC1A and USF2

Number of citations of the paper that reports this interaction (PMID 12611894)
7

Data Source:
HPRD (in vivo, in vitro)

		PPARGC1A	USF2
Gene Name		peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	upstream transcription factor 2, c-fos interacting
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm DNA-directed RNA Polymerase II, Core Complex Cytosol PML Body	Nucleus Nucleoplasm
	Molecular Function	Nucleotide Binding RNA Polymerase II Transcription Cofactor Activity DNA Binding Transcription Coactivator Activity RNA Binding Protein Binding Transcription Factor Binding Ligand-dependent Nuclear Receptor Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Chromatin DNA Binding Ubiquitin Protein Ligase Binding Sequence-specific DNA Binding Androgen Receptor Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity BHLH Transcription Factor Binding Sequence-specific DNA Binding Protein Heterodimerization Activity
	Biological Process	Temperature Homeostasis Cellular Glucose Homeostasis Galactose Metabolic Process Gluconeogenesis Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter MRNA Processing Protein Complex Assembly Organelle Organization Mitochondrion Organization Digestion Circadian Rhythm Androgen Metabolic Process RNA Splicing Response To Cold Positive Regulation Of Mitochondrion Organization Response To Muscle Activity Fatty Acid Oxidation Respiratory Electron Transport Chain Androgen Receptor Signaling Pathway Circadian Regulation Of Gene Expression Cellular Response To Oxidative Stress Positive Regulation Of Histone Acetylation Response To Statin Response To Starvation Regulation Of Circadian Rhythm Response To Leucine Negative Regulation Of Neuron Apoptotic Process Cellular Respiration Positive Regulation Of Gluconeogenesis Negative Regulation Of Glycolytic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Fatty Acid Oxidation Positive Regulation Of Smooth Muscle Cell Proliferation Protein Stabilization Brown Fat Cell Differentiation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Flavone Metabolic Process Cellular Response To Nitrite Cellular Response To Tumor Necrosis Factor Cellular Response To Fatty Acid Cellular Response To Hypoxia Response To Epinephrine Response To Norepinephrine Cellular Response To Thyroid Hormone Stimulus Negative Regulation Of Neuron Death Positive Regulation Of Cellular Respiration Positive Regulation Of Mitochondrial DNA Metabolic Process Positive Regulation Of Muscle Tissue Development Negative Regulation Of Receptor Activity Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Positive Regulation Of Energy Homeostasis Positive Regulation Of ATP Biosynthetic Process	Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Transcription From RNA Polymerase II Promoter Lactation Late Viral Transcription Positive Regulation Of Transcription From RNA Polymerase II Promoter Lipid Homeostasis
Pathways		PPARA activates gene expression Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins REV-ERBA represses gene expression RORA activates circadian gene expression Mitochondrial biogenesis Activation of PPARGC1A (PGC-1alpha) by phosphorylation Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis BMAL1:CLOCK,NPAS2 activates circadian gene expression
Drugs
Diseases
GWAS		Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Protein-Protein Interactions		40 interactors: CAPNS1 CDK6 CREBBP CREBZF ESR1 ESR2 ESRRA ESRRG FBXW7 GSK3B HCFC1 HNF4A LRPPRC MAPK14 MED1 MED12 MED14 MED17 MYBBP1A NCL NCOA1 NCOA6 NR1H4 NR1I2 NR1I3 NR3C1 NRF1 PPARA PPARD PPARG RXRA SIRT1 SRSF4 SRSF5 SRSF6 THRB TP53 UBC UBE2I USF2	11 interactors: BRCA1 EP300 FOS LZTS2 MAF NFYA PPARGC1A PPRC1 RELA TEAD2 USF1
Entrez ID		10891	7392
HPRD ID		05155	02668
Ensembl ID		ENSG00000109819	ENSG00000105698
Uniprot IDs		I3RTT5 I3RTT6 Q9UBK2	Q15853
PDB IDs		1XB7 3B1M 3CS8 3D24 3U9Q 3V9T 3V9V
Enriched GO Terms of Interacting Partners?		Transcription Initiation From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Hormone-mediated Signaling Pathway Steroid Hormone Mediated Signaling Pathway RNA Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Gene Expression Cellular Response To Steroid Hormone Stimulus Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Steroid Hormone Cellular Nitrogen Compound Metabolic Process Cellular Response To Lipid Biosynthetic Process Negative Regulation Of Gene Expression Nitrogen Compound Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Cellular Response To Organic Cyclic Compound Regulation Of Metabolic Process Response To Hormone Negative Regulation Of Biosynthetic Process Response To Lipid Cellular Response To Hormone Stimulus Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To Organic Cyclic Compound Cellular Response To Organic Substance Response To Organic Substance	Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Transcription, DNA-templated Positive Regulation Of Metabolic Process RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Gene Expression Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Response To Hormone Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Abiotic Stimulus Nitrogen Compound Metabolic Process Cellular Response To Tumor Necrosis Factor Response To Organonitrogen Compound Response To Lipid Response To Tumor Necrosis Factor Response To Organic Cyclic Compound Positive Regulation Of Histone Acetylation Response To Radiation Positive Regulation Of Peptidyl-lysine Acetylation Response To Extracellular Stimulus Positive Regulation Of Protein Acetylation Response To Steroid Hormone Regulation Of Metabolic Process Cellular Response To Organic Substance Response To Temperature Stimulus Intracellular Receptor Signaling Pathway Cellular Response To Oxidative Stress Cellular Response To Hormone Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Androgen Receptor Signaling Pathway
Tagcloud ?		ageing bisulfite chosen coefficients concordance cord d4z4 environage epigenetics foetal loop methylation mitochondrial mt nineteen ninety placenta placental pyrosequencing ranging reproductive rnr1 scheme sides signature sirt1 subtelomeric tfam	anomalies behind bioinformatics cart ctf dependence depicting ebpbeta elaborate govern instance intron likewise modify nfya nutshell oprk1 pdyn pdyns pharmaceutical prodynorphin prompting regimes retrieve snps tbp vdr vulnerability
Tagcloud (Difference) ?		ageing bisulfite chosen coefficients concordance cord d4z4 environage epigenetics foetal loop methylation mitochondrial mt nineteen ninety placenta placental pyrosequencing ranging reproductive rnr1 scheme sides signature sirt1 subtelomeric tfam	anomalies behind bioinformatics cart ctf dependence depicting ebpbeta elaborate govern instance intron likewise modify nfya nutshell oprk1 pdyn pdyns pharmaceutical prodynorphin prompting regimes retrieve snps tbp vdr vulnerability
Tagcloud (Intersection) ?