PPARGC1A and USF1

Number of citations of the paper that reports this interaction (PubMedID 12611894)
0

Data Source:
BioGRID (pull down)

		PPARGC1A	USF1
Description		PPARG coactivator 1 alpha	upstream transcription factor 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol PML Body	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Golgi Apparatus
	Molecular Function	Nucleic Acid Binding DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity RNA Binding Protein Binding Nuclear Receptor Binding Chromatin DNA Binding Ubiquitin Protein Ligase Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding LncRNA Binding DNA-binding Transcription Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Enzyme Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding Protein-containing Complex Binding Protein Heterodimerization Activity Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Temperature Homeostasis Intracellular Glucose Homeostasis Response To Dietary Excess Gluconeogenesis Regulation Of DNA-templated Transcription Transcription Initiation At RNA Polymerase II Promoter MRNA Processing Mitochondrion Organization Digestion RNA Splicing Positive Regulation Of Gene Expression Response To Muscle Activity Fatty Acid Oxidation Respiratory Electron Transport Chain Developmental Process Circadian Regulation Of Gene Expression Cellular Response To Oxidative Stress Homeostatic Process Response To Starvation Regulation Of Circadian Rhythm Negative Regulation Of Neuron Apoptotic Process Cellular Respiration Positive Regulation Of Gluconeogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fatty Acid Oxidation Rhythmic Process Negative Regulation Of Smooth Muscle Cell Proliferation Protein Stabilization Brown Fat Cell Differentiation Neuron Apoptotic Process Adipose Tissue Development Protein-containing Complex Assembly Energy Homeostasis Positive Regulation Of Cold-induced Thermogenesis	Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Response To Hypoxia Glucose Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Response To UV Glucose Mediated Signaling Pathway Late Viral Transcription Cellular Response To Insulin Stimulus Glucose Homeostasis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Carbon Catabolite Regulation Of Transcription Negative Regulation Of Fibrinolysis Lipid Homeostasis Cellular Response To Glucose Stimulus
Pathways		PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Transcriptional activation of mitochondrial biogenesis Activation of PPARGC1A (PGC-1alpha) by phosphorylation Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation SUMOylation of transcription cofactors Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Heme signaling MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of MITF-M dependent genes involved in metabolism Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	Estrogen-dependent gene expression Regulation of MITF-M-dependent genes involved in pigmentation
Drugs
Diseases			Familial combined hyperlipidemia (FCHL)
GWAS		Aspartate aminotransferase levels ( 33547301) Coffee consumption ( 31046077) Cognitive decline rate in late mild cognitive impairment ( 26252872) Corneal astigmatism ( 29422769) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Essential tremor ( 27797806) Estimated glomerular filtration rate ( 31152163 31015462) Femur bone mineral density x serum urate levels interaction ( 34046847) Hematocrit ( 32888494) Hemoglobin ( 32888494) Intralaminar thalamic nuclei volume ( 34006833) Lead levels ( 26025379) Molar-incisor hypomineralization ( 23918034) PR interval ( 32439900) Refractive error ( 32231278) Resting heart rate ( 27798624) Rosacea symptom severity ( 29771307) Schizophrenia ( 30285260) Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) ( 31557306) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)	Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 23128233) Night sleep phenotypes ( 27126917)
Interacting Genes		44 interacting genes: CAPNS1 CDK6 CREBBP ESR1 ESR2 ESRRA ESRRG FBXW7 GSK3B HCFC1 HNF4A LRPPRC MAPK14 MED1 MED12 MED14 MED17 MYBBP1A NCL NCOA1 NCOA6 NDN NR1H4 NR1I2 NR1I3 NR3C1 NRF1 PPARA PPARD PPARG RARB RNF10 RXRA SIRT1 SKP1 SRSF4 SRSF5 SRSF6 THRB TP53 UBC UBE2I USF1 USF2	20 interacting genes: APP ESR1 FBXO7 FOS FOSL1 GTF2I HDAC9 HOMEZ LAP3 MAP3K7CL NFYA PLEKHF2 PPARGC1A PRKDC SNW1 TAOK2 TCF3 TCFL5 TRAF2 USF2
Entrez ID		10891	7391
HPRD ID		05155	01880
Ensembl ID		ENSG00000109819	ENSG00000158773
Uniprot IDs		D6RBF3 Q9UBK2	A0A0S2Z4U5 P22415
PDB IDs		1XB7 3B1M 3CS8 3D24 3U9Q 3V9T 3V9V 4QJR 4QK4 5Q0I 5TWO 5UNJ 5Z5S 5Z6S 6AD9 6FZF 6FZP 6IZM 6IZN 6K0T 6KXX 6KXY 6LN4 6MS7 6NWK 6NWL 6T1V 6W9K 6W9L 7E2E 7KHT 7PRV 7PRW 7PRX 8BF1 8DK4 9F7W 9F7X	1AN4
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II Nuclear Receptor Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Nuclear Receptor-mediated Signaling Pathway Intracellular Receptor Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific DNA Binding Hormone-mediated Signaling Pathway Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Chromatin Negative Regulation Of Macromolecule Metabolic Process Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Nuclear Steroid Receptor Activity DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Intracellular Signal Transduction Rhythmic Process Estrogen Response Element Binding Transcription Coactivator Binding Peroxisome Proliferator Activated Receptor Signaling Pathway Nuclear Vitamin D Receptor Binding	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Chromatin Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Positive Regulation Of RNA Metabolic Process Nucleoplasm Nucleus DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of MiRNA Transcription Cellular Response To Oxygen-containing Compound Regulation Of MiRNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Transcription Regulator Complex Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Transcription By RNA Polymerase II Protein-DNA Complex RNA Polymerase II Transcription Regulator Complex B Cell Lineage Commitment Regulation Of Developmental Process Regulation Of Primary Metabolic Process Mononuclear Cell Differentiation Leukocyte Activation Immunoglobulin V(D)J Recombination Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Leukocyte Differentiation Enzyme Binding Cell Activation RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Metabolic Process RNA Metabolic Process DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Macromolecule Metabolic Process Regulation Of Multicellular Organismal Process Lymphocyte Activation Mitogen-activated Protein Kinase Kinase Kinase Binding Protein-containing Complex
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