KIF26B and MAP4K4

Number of citations of the paper that reports this interaction (PubMedID 20936779)
36

Data Source:
BioGRID (two hybrid)

		KIF26B	MAP4K4
Description		kinesin family member 26B	mitogen-activated protein kinase kinase kinase kinase 4
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Microtubule	Cytoplasm Focal Adhesion
	Molecular Function	Nucleotide Binding Microtubule Motor Activity ATP Binding Microtubule Binding	Nucleotide Binding Creatine Kinase Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding MAP Kinase Kinase Kinase Kinase Activity Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Microtubule-based Movement Positive Regulation Of Cell-cell Adhesion Establishment Of Cell Polarity System Development Ureteric Bud Invasion	MAPK Cascade Negative Regulation Of Cell-matrix Adhesion Protein Phosphorylation Positive Regulation Of Cell Migration Positive Regulation Of ARF Protein Signal Transduction Hippo Signaling Positive Regulation Of Hippo Signaling Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of MAPK Cascade Regulation Of JNK Cascade Neuron Projection Morphogenesis Positive Regulation Of Keratinocyte Migration Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Focal Adhesion Disassembly Positive Regulation Of Intracellular Signal Transduction
Pathways		COPI-dependent Golgi-to-ER retrograde traffic Kinesins	Oxidative Stress Induced Senescence
Drugs			Fostamatinib
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Daytime sleep phenotypes ( 27126917) Diverticular disease ( 30177863) Fasting insulin ( 34074324) Ischemic heart disease in rheumatoid arthritis ( 30251476) Metabolite levels ( 23823483) Myeloperoxidase-DNA complexes ( 33717105) Prudent dietary pattern ( 28644415) Response to serotonin reuptake inhibitors in non-psychotic unipolar depression ( 26348319) Schizophrenia ( 23212062) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Venous thromboembolism ( 33592630)	Alzheimer's disease ( 30636644) Asthma ( 31619474) Asthma (time to onset) ( 27130862) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) White blood cell count ( 32888494)
Interacting Genes		7 interacting genes: CDK1 CDK2 CDK5 CDK6 MAP4K4 MX1 TRAF2	27 interacting genes: BRCA1 CASP8 CTTNBP2NL DOK1 DSCAM GBP3 H2BC21 ITGB1 KIF26B KIF5A LATS1 MAP3K7 MOB4 NCK1 NME7 PPP1CA PPP1CC PPP2CA PRKCE PTK2B RAP2A RASA1 RIPPLY3 SLC9A1 STRIP1 STRN4 TBPL2
Entrez ID		55083	9448
HPRD ID		13332	05235
Ensembl ID		ENSG00000162849	ENSG00000071054
Uniprot IDs		B7WPD9 Q2KJY2	B7Z3V5 E7EN19 G5E948 O95819 V9HWH3
PDB IDs			4OBO 4OBP 4OBQ 4RVT 4U3Y 4U3Z 4U40 4U41 4U42 4U43 4U44 4U45 4ZK5 4ZP5 5DI1 5J95 5W5Q 8V5I
Enriched GO Terms of Interacting Partners?		Cyclin-dependent Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Kinase Holoenzyme Complex Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Cyclin Binding Protein Kinase Activity Cyclin-dependent Protein Kinase Activity Kinase Activity Histone Kinase Activity Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Transferase Activity Negative Regulation Of Cell Cycle Nucleotide Binding Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Cell Cycle Phase Transition Cell Division Cellular Response To Nitric Oxide Cellular Response To Reactive Nitrogen Species Mitotic Cell Cycle Phase Transition Response To Nitric Oxide Cell Cycle Phase Transition ATP Binding Regulation Of Cell Cycle Process Microtubule Binding Positive Regulation Of DNA Replication Intracellular Signaling Cassette G2/M Transition Of Mitotic Cell Cycle Cellular Response To Oxygen-containing Compound Cell Cycle G2/M Phase Transition Apoptotic Process Protein Phosphorylation Regulation Of Mitotic Cell Cycle Phase Transition Programmed Cell Death Cell Death Positive Regulation Of Cell-matrix Adhesion Glial Cell Development Mitotic DNA Damage Checkpoint Signaling Pronuclear Fusion Mitotic DNA Integrity Checkpoint Signaling Phosphorylation Negative Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Presynaptic Cytosolic Calcium Concentration Cyclin D2-CDK6 Complex TORC2 Complex Disassembly Regulation Of Cell Cycle Microtubule Organizing Center Organization Mitotic DNA-templated DNA Replication Cyclin B1-CDK1 Complex	FAR/SIN/STRIPAK Complex Regulation Of Hippo Signaling Regulation Of Intracellular Signal Transduction Regulation Of Cytoskeleton Organization Negative Regulation Of Hippo Signaling Regulation Of Supramolecular Fiber Organization Cytoplasm Regulation Of Signal Transduction Negative Regulation Of Intracellular Signal Transduction Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Organization Regulation Of Actin Filament Length Regulation Of Cellular Component Size RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Regulation Of Protein-containing Complex Assembly Regulation Of Cellular Component Organization Perinuclear Region Of Cytoplasm Regulation Of Cell Communication Regulation Of Signaling Lamellipodium Protein Dephosphorylation Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Protein-containing Complex Assembly Glutamatergic Synapse Protein-macromolecule Adaptor Activity Regulation Of Actin Filament-based Process Postsynapse Positive Regulation Of Locomotion Negative Regulation Of Signal Transduction Response To Tumor Necrosis Factor Negative Regulation Of Cell Communication Regulation Of Organelle Organization Negative Regulation Of Signaling Dephosphorylation PTW/PP1 Phosphatase Complex Positive Regulation Of Actin Filament Polymerization Signal Complex Assembly Signaling Receptor Activator Activity Dendritic Spine Positive Regulation Of Pyroptotic Inflammatory Response Regulation Of Synapse Organization Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Cellular Component Biogenesis Gamma-tubulin Ring Complex Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Apoptotic Process Phosphate-containing Compound Metabolic Process Regulation Of Locomotion Positive Regulation Of Programmed Cell Death
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