FYN and STAT1

Number of citations of the paper that reports this interaction (PubMedID 9804857)
0

Data Source:
HPRD (in vivo)

		FYN	STAT1
Description		FYN proto-oncogene, Src family tyrosine kinase	signal transducer and activator of transcription 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Endosome Cytosol Actin Filament Plasma Membrane Postsynaptic Density Membrane Dendrite Perikaryon Cell Body Membrane Raft Perinuclear Region Of Cytoplasm Cell Periphery Perinuclear Endoplasmic Reticulum Glial Cell Projection Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Postsynaptic Density, Intracellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Axon Dendrite Protein-containing Complex Perinuclear Region Of Cytoplasm ISGF3 Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Nucleotide Binding G Protein-coupled Receptor Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Tubulin Binding Phospholipase Activator Activity Kinase Activity Transferase Activity Enzyme Binding Type 5 Metabotropic Glutamate Receptor Binding T Cell Receptor Binding CD4 Receptor Binding CD8 Receptor Binding Identical Protein Binding Alpha-tubulin Binding Phospholipase Binding Phosphatidylinositol 3-kinase Binding Transmembrane Transporter Binding Protein-containing Complex Binding Metal Ion Binding Ephrin Receptor Binding Tau Protein Binding Tau-protein Kinase Activity Peptide Hormone Receptor Binding Growth Factor Receptor Binding Scaffold Protein Binding Disordered Domain Specific Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Corepressor Binding Transcription Coactivator Binding DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Tumor Necrosis Factor Receptor Binding Protein Binding Enzyme Binding CCR5 Chemokine Receptor Binding Histone Acetyltransferase Binding Histone Binding Identical Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Ubiquitin-like Protein Ligase Binding Cadherin Binding Protein Phosphatase 2A Binding Promoter-specific Chromatin Binding
	Biological Process	Response To Singlet Oxygen Neuron Migration Stimulatory C-type Lectin Receptor Signaling Pathway Adaptive Immune Response Immune System Process Negative Regulation Of Inflammatory Response To Antigenic Stimulus Heart Process Calcium Ion Transport Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Axon Guidance Learning Feeding Behavior Regulation Of Cell Shape Response To Xenobiotic Stimulus Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Neuron Projection Development Negative Regulation Of Angiogenesis Protein Ubiquitination Peptidyl-tyrosine Phosphorylation Layer Formation In Cerebral Cortex Natural Killer Cell Activation Cell Differentiation Protein Catabolic Process Forebrain Development Neuron Projection Development T Cell Costimulation Negative Regulation Of Protein Ubiquitination Intracellular Signal Transduction Cellular Response To Platelet-derived Growth Factor Stimulus Reelin-mediated Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Protein Catabolic Process Response To Cocaine Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Neuron Apoptotic Process Response To Ethanol Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Dendrite Morphogenesis Activated T Cell Proliferation Modulation Of Chemical Synaptic Transmission T Cell Receptor Signaling Pathway Leukocyte Migration Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Hydrogen Peroxide Cellular Response To Growth Factor Stimulus Cellular Response To Peptide Hormone Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Protein Targeting To Membrane Dendritic Spine Maintenance Positive Regulation Of Protein Localization To Nucleus Regulation Of Glutamate Receptor Signaling Pathway Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Dendritic Spine Maintenance Response To Amyloid-beta Cellular Response To Amyloid-beta Cellular Response To L-glutamate Cellular Response To Glycine Positive Regulation Of Protein Localization To Membrane Regulation Of Calcium Ion Import Across Plasma Membrane Regulation Of Neuron Migration Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Defense Response To Virus By Host Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Response To Nutrient Blood Circulation Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Mechanical Stimulus Negative Regulation Of Angiogenesis Positive Regulation Of Interferon-alpha Production Cellular Response To Insulin Stimulus Tumor Necrosis Factor-mediated Signaling Pathway Response To Cytokine Response To Type II Interferon Response To Interferon-beta Cellular Response To Interferon-beta Interleukin-7-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Regulation Of Cell Population Proliferation Response To Hydrogen Peroxide Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Response To Peptide Hormone Endothelial Cell Migration Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation By Virus Of Viral Protein Levels In Host Cell Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Developmental Process Response To CAMP Defense Response To Virus Type II Interferon-mediated Signaling Pathway Type I Interferon-mediated Signaling Pathway Renal Tubule Development Interleukin-27-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Cellular Response To Type II Interferon Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Metanephric Mesenchymal Cell Differentiation Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Cell Surface Receptor Signaling Pathway Via STAT
Pathways		GPVI-mediated activation cascade Signaling by ERBB2 PIP3 activates AKT signaling Signaling by SCF-KIT Signaling by SCF-KIT Regulation of KIT signaling Nef and signal transduction Cell surface interactions at the vascular wall FCGR activation PECAM1 interactions Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling DAP12 signaling EPH-Ephrin signaling Role of LAT2/NTAL/LAB on calcium mobilization Nephrin family interactions Nephrin family interactions NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Co-stimulation by CD28 CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway Co-inhibition by CTLA4 EPHB-mediated forward signaling EPHB-mediated forward signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling CRMPs in Sema3A signaling VEGFA-VEGFR2 Pathway Dectin-2 family CD209 (DC-SIGN) signaling RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Platelet Adhesion to exposed collagen Reelin signalling pathway Regulation of signaling by CBL Regulation of signaling by CBL FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by CSF1 (M-CSF) in myeloid cells FLT3 signaling through SRC family kinases Antigen activates B Cell Receptor (BCR) leading to generation of second messengers High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Interleukin-6 signaling ISG15 antiviral mechanism Signaling by SCF-KIT Signaling by cytosolic FGFR1 fusion mutants Downstream signal transduction Interleukin-4 and Interleukin-13 signaling Interleukin-20 family signaling Regulation of RUNX2 expression and activity Interleukin-35 Signalling Interleukin-9 signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription Interleukin-27 signaling Interleukin-21 signaling Interferon alpha/beta signaling Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants Signaling by CSF3 (G-CSF) Signaling by CSF1 (M-CSF) in myeloid cells Inactivation of CSF3 (G-CSF) signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses Signaling by ALK fusions and activated point mutants Growth hormone receptor signaling PKR-mediated signaling Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Regulation of PD-L1(CD274) transcription
Drugs		Dasatinib Triglyme Fostamatinib Zotiraciclib
Diseases			Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF) IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Anger ( 24489884) Autoimmune thyroid disease ( 32581359) Bipolar disorder ( 31043756) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 31562340) Inflammatory bowel disease ( 28067908 23128233) Intraocular pressure ( 29617998) Macular thickness ( 30535121) NASH resolution in nonalcoholic steatohepatitis ( 31832568) Parkinson's disease ( 32201043 32310270) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Schizophrenia ( 28991256 30285260) Systolic blood pressure ( 30578418) Ulcerative colitis ( 28067908)	Birth weight ( 31043758) Height ( 31562340) Inflammatory bowel disease ( 23128233) JT interval (sulfonylurea treatment interaction) ( 27958378) Limited cutaneous systemic scleroderma ( 29293537) Lung cancer (SNP x SNP interaction) ( 24325914) Metabolite levels ( 23823483) Neutrophil percentage of granulocytes ( 27863252) Primary biliary cholangitis ( 26394269 28425483) Primary biliary cirrhosis ( 22961000) Systemic lupus erythematosus ( 26316170) Systemic sclerosis ( 29293537)
Interacting Genes		199 interacting genes: ACP1 ADAM15 ADD2 ARHGAP32 ARHGAP33 ATXN1 BAG4 BCAR1 BCL3 BTK C7orf25 C8orf33 CASP3 CASP8 CAV1 CBL CBLB CBLC CD19 CD2 CD226 CD247 CD2AP CD36 CD44 CD48 CD5 CD55 CD79A CD79B CDH1 CDK1 CDK5 CLTC CMA1 CNN1 CNN3 CNTN1 CNTNAP1 CRK CSF1R CSF2RB CSK CTLA4 CTNNB1 CTNND2 DAG1 DLG4 DLGAP4 DOK1 DOK3 DOK4 DTX3 EFS ENO1 EPHA3 EPHA4 EPHA8 EPHB3 EVL FAM90A1 FAS FASLG FCER2 FCGR2A FLOT1 FLOT2 FLT1 FNBP4 FYB1 GAB3 GP6 GRAP GRB10 GRB2 GRIN1 GRIN2A GRIN2B GRSF1 HNRNPK HRAS HSP90AA1 HTR6 IGHA1 IL1B IL2RB IL7R IRS1 ITCH ITGB4 ITK ITPR1 JAK2 JUP KDM1A KDR KHDRBS1 KIT LAT LCK LCP2 MAG MAP2 MAPT MCAM MED28 MEOX2 MS4A1 NCAM1 NEDD4 NEDD9 NMT1 NOS1AP NPHS1 NR3C1 NTRK2 PAG1 PAK2 PDE4D PDGFRB PECAM1 PIK3R1 PIK3R2 PIK3R3 PLAUR PLCG1 PLCG2 PLD2 PRKCD PRKCE PRKCH PRKCQ PRKCZ PRMT6 PRMT8 PRRG4 PTK2 PTK2B PTPN11 PTPN5 PTPRA PTPRC PTPRE PTPRF PTPRZ1 PXN RACK1 RAF1 RPL10 RPS6KA3 RPS6KB2 SDC3 SH2B2 SH2D1A SH3BP2 SHC1 SIT1 SKAP1 SKAP2 SLAMF1 SNCA SOCS1 SOS1 SPHK1 SPHK2 SPN STAT1 STAT3 SUV39H1 SYK TAMALIN TCAP THY1 TNF TNK2 TNNT1 TOM1L1 TRAF6 TRAT1 TRIM55 TRIM63 TRPC6 TRPV4 TUBA1B TUBA3C TUBA4A TXK TYK2 TYRO3 UHRF2 UNC119 VAV1 VAV2 WAS WASF1 WASF2 WBP11 YTHDC1 ZAP70	112 interacting genes: ACTN4 ADRA1B AIRN AKT1 ATF3 BMX BRCA1 CAMK2A CAMK2D CAMK2G CASP3 CASP7 CCR1 CCR5 CDC42 CEBPA CREBBP CSE1L CSF2RB CXCR4 DCTN1 DDB1 DDX6 DOT1L DUSP2 DUSP3 E2F1 EGFR EIF1AD EIF2AK2 ELP2 EP300 FADD FANCC FGFR3 FGFR4 FLT1 FOS FTH1 FYN GFAP GTF2I HADH HLA-B HSF1 HSP90AB1 HSPA8 IFNAR2 IFNGR1 IL27RA IL2RB IL2RG IRF1 IRF2 IRF9 JAK1 JAK2 JUN KDR KIT KPNA1 KPNA6 LCK LMO2 LZTR1 MAPK14 MAVS MCM3 MCM5 MDK MT-ND4L NMI NOMO1 NOMO2 OTUD4 PDGFRA PDGFRB PIAS1 PIAS2 PIK3CA PKNOX1 POR PRKCD PRMT1 PRMT3 PTK2 PTPN11 PTPN2 RAC1 RACK1 RELA RPS6KA5 RXRA SHANK1 SPTAN1 SPTB SPTBN1 SRC STAT2 STAT3 STAT5A STAT5B SUMO4 SYK TNFRSF1A TNFRSF1B TRADD TYK2 UBE2I VDR XPO1 ZNF467
Entrez ID		2534	6772
HPRD ID		00655	02777
Ensembl ID		ENSG00000010810	ENSG00000115415
Uniprot IDs		P06241	A0A669KB68 A0A8V8TN81 P42224
PDB IDs		1A0N 1AOT 1AOU 1AVZ 1AZG 1EFN 1FYN 1G83 1M27 1NYF 1NYG 1SHF 1ZBJ 2DQ7 2MQI 2MRJ 2MRK 3H0F 3H0H 3H0I 3UA6 3UA7 4D8D 4EIK 4U17 4U1P 4ZNX 5ZAU 6EDF 6IPY 6IPZ 7A2J 7A2K 7A2L 7A2M 7A2N 7A2O 7A2P 7A2Q 7A2R 7A2S 7A2T 7A2U 7A2V 7A2W 7A2X 7A2Y 7A2Z 7UD6 8KDX	1BF5 1YVL 2KA6 3WWT 7NUF 8D3F
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Signal Transduction Plasma Membrane Immune System Process Regulation Of Immune System Process Positive Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Immune Response Immune Response-activating Signaling Pathway Activation Of Immune Response Antigen Receptor-mediated Signaling Pathway Regulation Of Multicellular Organismal Process Regulation Of Signal Transduction Regulation Of Cell Adhesion Leukocyte Activation Enzyme-linked Receptor Protein Signaling Pathway Cell Activation Positive Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Regulation Of Cellular Component Organization Phosphotyrosine Residue Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Multicellular Organismal Process Lymphocyte Activation Positive Regulation Of Cell Adhesion Membrane Raft Regulation Of Cell Activation T Cell Receptor Signaling Pathway Cell Migration Positive Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Protein Tyrosine Kinase Activity Immune Response Regulation Of Cell-cell Adhesion Regulation Of Programmed Cell Death Intracellular Signaling Cassette Fc Receptor Signaling Pathway Regulation Of Apoptotic Process SH2 Domain Binding Adaptive Immune Response Cell Adhesion Protein Kinase Binding	Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Cell Communication Regulation Of Signal Transduction Regulation Of Signaling Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Tyrosine Kinase Activity Positive Regulation Of Signal Transduction Regulation Of Macromolecule Metabolic Process Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Metabolic Process Signal Transduction Regulation Of Multicellular Organismal Process Cell Surface Receptor Signaling Pathway Via STAT Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Primary Metabolic Process Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Developmental Process Positive Regulation Of Macromolecule Metabolic Process Response To Stress Positive Regulation Of Multicellular Organismal Process Regulation Of Programmed Cell Death Positive Regulation Of Developmental Process Positive Regulation Of Biosynthetic Process Regulation Of Apoptotic Process Immune System Process Protein Kinase Activity Regulation Of Cell Population Proliferation Regulation Of Nucleobase-containing Compound Metabolic Process Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Immune System Process Phosphorylation Protein Phosphorylation Regulation Of Defense Response Regulation Of Cell Differentiation Regulation Of Multicellular Organismal Development Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Migration Kinase Activity Response To Lipid Defense Response Response To Peptide Positive Regulation Of Cell Differentiation
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