NES and CDK5R1

Number of citations of the paper that reports this interaction (PMID 12832492)
28

Data Source:
HPRD (in vivo)

		NES	CDK5R1
Gene Name		nestin	cyclin-dependent kinase 5, regulatory subunit 1 (p35)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Intermediate Filament Intermediate Filament Cytoskeleton	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Membrane Cyclin-dependent Protein Kinase 5 Holoenzyme Complex Axon Dendrite Growth Cone Neuromuscular Junction Neuronal Cell Body Dendritic Spine Intracellular Membrane-bounded Organelle Contractile Fiber Perinuclear Region Of Cytoplasm
	Molecular Function	Molecular_function Structural Molecule Activity Intermediate Filament Binding	Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Calcium Ion Binding Protein Binding Kinase Activity Cyclin-dependent Protein Kinase 5 Activator Activity Protein Kinase Binding Protein Serine/threonine Kinase Activator Activity Cadherin Binding Ephrin Receptor Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Central Nervous System Development Brain Development Positive Regulation Of Intermediate Filament Depolymerization Embryonic Camera-type Eye Development Negative Regulation Of Protein Binding Negative Regulation Of Catalytic Activity Negative Regulation Of Neuron Apoptotic Process Cell Projection Morphogenesis Stem Cell Proliferation Positive Regulation Of Neural Precursor Cell Proliferation	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Neuron Migration Neuron Cell-cell Adhesion G-protein Coupled Acetylcholine Receptor Signaling Pathway Axon Guidance Axonal Fasciculation Brain Development Cell Proliferation Embryo Development Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Cerebellum Development Superior Olivary Nucleus Maturation Hippocampus Development Layer Formation In Cerebral Cortex Neuron Differentiation Negative Regulation Of Axon Extension Neuron Projection Development Regulation Of Actin Cytoskeleton Organization Serine Phosphorylation Of STAT3 Protein Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Negative Regulation Of Transcription, DNA-templated Ephrin Receptor Signaling Pathway Rhythmic Process Regulation Of Dendritic Spine Morphogenesis Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Targeting To Membrane
Pathways			Axon guidance Semaphorin interactions CRMPs in Sema3A signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: CDK1 CDK5 CDK5R1 IDE	31 interactors: ACTN1 AMPH APP BLOC1S6 CAMK2A CAPN1 CAPN2 CDK16 CDK5 CDK5RAP1 CDK5RAP2 CDK5RAP3 CDK9 CHN1 CTNNB1 HSP90AA1 KRT40 KRTAP10-3 LMTK2 MAPT MTUS2 NEDD4 NES NOTCH2NL ODF1 PAK1 SET SIAH1 STXBP1 TSC22D4 TTBK1
Entrez ID		10763	8851
HPRD ID		09020	04586
Ensembl ID		ENSG00000132688	ENSG00000176749
Uniprot IDs		P48681 Q9H6U9	Q15078 Q8N619
PDB IDs			1H4L 1UNG 1UNH 1UNL 3O0G
Enriched GO Terms of Interacting Partners?		Peptidyl-threonine Phosphorylation Serine Phosphorylation Of STAT3 Protein Serine Phosphorylation Of STAT Protein Peptidyl-serine Phosphorylation Positive Regulation Of Intracellular Protein Transport Positive Regulation Of Intracellular Transport Regulation Of Intracellular Protein Transport Negative Regulation Of Axon Extension Regulation Of Developmental Growth Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Protein Transport Layer Formation In Cerebral Cortex Axon Guidance Cerebral Cortex Radial Glia Guided Migration Regulation Of Dendritic Spine Development Regulation Of Intracellular Transport Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Neuron Apoptotic Process Cerebral Cortex Radially Oriented Cell Migration Negative Regulation Of Axonogenesis Glial Cell Migration Axonogenesis Regulation Of Cellular Protein Metabolic Process Regulation Of Axon Extension Positive Regulation Of Transferase Activity Regulation Of Dendrite Morphogenesis Hippocampus Development Axon Development Positive Regulation Of Neuron Death Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Regulation Of Growth Regulation Of Protein Transport Regulation Of Protein Metabolic Process Neuron Projection Morphogenesis Negative Regulation Of Developmental Growth Cerebral Cortex Cell Migration Regulation Of JAK-STAT Cascade Regulation Of Proteolysis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Establishment Of Protein Localization Limbic System Development Regulation Of Cell Cycle Arrest Regulation Of Neurogenesis Negative Regulation Of Cell Morphogenesis Involved In Differentiation Telencephalon Cell Migration Cell Morphogenesis Involved In Differentiation Positive Regulation Of Protein Phosphorylation	Generation Of Neurons Nervous System Development Neurogenesis Establishment Of Localization In Cell Neuron Projection Development Cellular Localization Neuron Differentiation Cell Differentiation Cell Projection Organization Neuron Development Multicellular Organismal Development Vesicle-mediated Transport Regulation Of Organelle Organization Regulation Of Neurogenesis Establishment Of Organelle Localization Regulation Of Cellular Component Organization Developmental Process Cell Morphogenesis Involved In Differentiation Exocytosis Axonogenesis Synaptic Vesicle Transport Regulation Of Neuron Differentiation Cell Morphogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Cell Projection Morphogenesis Cell Development Regulation Of Cell Development System Development Cell Part Morphogenesis Organelle Localization Neuron Projection Morphogenesis Receptor Catabolic Process Anatomical Structure Development Synapse Organization Regulation Of Cytoskeleton Organization Secretion By Cell Brain Development Receptor Metabolic Process Response To Abiotic Stimulus Head Development Establishment Of Vesicle Localization Negative Regulation Of Neuron Death Vesicle Localization Axon Guidance Regulation Of Cell Differentiation Secretion Anatomical Structure Morphogenesis Regulation Of Cell Cycle Locomotion
Tagcloud ?		autoinhibitory bipartite carries cytoplasm exclusively export exportin gfp hydrophobic import keywords leptomycin leucine mapkap mimicry mk2 nls overlapping redistribution rev sb203580 spacing supposed t317 t317a translocates translocation unexpectedly unlike	10a 200c 30a 30c arhgap5 cd36 cdh2 chips cyp27b1 figure gemcitabine gna13 gp5 hist1h2bf hlf igsf3 ikbkb il32 intriguing mirs nrp2 oxidoreductase pak7 putatively rab23 rap2a slc11a1 sod3 tp53i3
Tagcloud (Difference) ?		autoinhibitory bipartite carries cytoplasm exclusively export exportin gfp hydrophobic import keywords leptomycin leucine mapkap mimicry mk2 nls overlapping redistribution rev sb203580 spacing supposed t317 t317a translocates translocation unexpectedly unlike	10a 200c 30a 30c arhgap5 cd36 cdh2 chips cyp27b1 figure gemcitabine gna13 gp5 hist1h2bf hlf igsf3 ikbkb il32 intriguing mirs nrp2 oxidoreductase pak7 putatively rab23 rap2a slc11a1 sod3 tp53i3
Tagcloud (Intersection) ?