ALYREF and IL7R

Number of citations of the paper that reports this interaction (PMID 23151878)
3

Data Source:
BioGRID (unspecified method)

		ALYREF	IL7R
Gene Name		Aly/REF export factor	interleukin 7 receptor
Image
Gene Ontology Annotations	Cellular Component	Transcription Export Complex Nucleus Nucleoplasm Cytosol Membrane Nuclear Speck Exon-exon Junction Complex Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome Catalytic Step 2 Spliceosome	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Nucleotide Binding Single-stranded DNA Binding Protein Binding Poly(A) RNA Binding	Antigen Binding Interleukin-7 Receptor Activity Protein Binding
	Biological Process	Regulation Of DNA Recombination MRNA Splicing, Via Spliceosome Osteoblast Differentiation Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Export From Nucleus RNA Splicing Gene Expression MRNA 3'-end Processing Replication Fork Processing Positive Regulation Of DNA-templated Transcription, Elongation Viral MRNA Export From Host Cell Nucleus	Regulation Of DNA Recombination Cell Morphogenesis Negative Regulation Of T Cell Mediated Cytotoxicity Immunoglobulin Production Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Cell Size Positive Regulation Of Gene Expression Cell Growth T Cell Differentiation Positive Regulation Of T Cell Differentiation In Thymus Interleukin-7-mediated Signaling Pathway B Cell Proliferation Lymph Node Development Homeostasis Of Number Of Cells
Pathways		Transport of Mature mRNA Derived from an Intronless Transcript Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing Transport of the SLBP Dependant Mature mRNA RNA Polymerase II Transcription Transport of Mature mRNA derived from an Intron-Containing Transcript Transport of Mature mRNAs Derived from Intronless Transcripts Transport of the SLBP independent Mature mRNA Cleavage of Growing Transcript in the Termination Region mRNA Splicing - Major Pathway mRNA 3'-end processing Transport of Mature Transcript to Cytoplasm RNA Polymerase II Transcription Termination	Signaling by Interleukins Interleukin-7 signaling Cytokine Signaling in Immune system
Drugs
Diseases
GWAS			Multiple sclerosis ( 21244703 19525953 21833088) Primary biliary cirrhosis ( 23000144 21399635) Type 1 diabetes ( 17554260) Ulcerative colitis ( 21297633)
Protein-Protein Interactions		11 interactors: AKT1 DDX39B IL7R LEF1 MAGOH NXF1 RUNX2 THOC1 THOC6 THOC7 UPF3A	104 interactors: ALYREF CIRBP CPSF1 CRLF2 DDX21 DDX39B DDX3X DDX5 DHX36 DHX9 EIF2AK2 ELAVL1 EMG1 FAU FUS FYN G3BP1 GNB2L1 H1FX HIST1H1C HIST1H1E HIST2H2BE HNRNPA0 HNRNPA3 HNRNPAB HNRNPC HNRNPD HNRNPDL HNRNPH3 HNRNPL HNRNPR HNRNPU HNRNPUL1 HNRNPUL2 IL2RG IL7 ILF2 ILF3 JAK1 JAK3 KIT LYN MAP4 NCL NONO PABPC1 PABPC4 PABPN1 PIK3R1 PTBP1 PTK2B PTMA PURA PURB QKI RAD21 RBM3 RBMX RPL15 RPL18 RPL22 RPL29 RPL30 RPL31 RPL6 RPL7 RPL8 RPS20 RPS3 RPSA RRAGA RSL1D1 SAFB SF1 SF3A1 SF3B1 SNRNP70 SNRPA SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG SRP14 SRP9 SRSF3 SRSF9 SSB STAT3 STAT5A STAT5B SYNCRIP TOE1 TOP1 TSLP U2AF1 U2AF2 YBX1 YBX3 YWHAE YWHAG ZNF787
Entrez ID		10189	3575
HPRD ID		09168	00893
Ensembl ID		ENSG00000183684	ENSG00000168685
Uniprot IDs		E9PB61 Q86V81	D6RGV2 D9N160 P16871
PDB IDs		3ULH	3DI2 3DI3 3UP1
Enriched GO Terms of Interacting Partners?		MRNA Transport Nucleocytoplasmic Transport Nuclear Transport RNA Transport RNA Localization MRNA Export From Nucleus RNA Export From Nucleus Viral MRNA Export From Host Cell Nucleus Nuclear Export Cytoplasmic Transport Intracellular Transport Of Virus Intracellular Transport Gene Expression MRNA Metabolic Process RNA Splicing Establishment Of Localization In Cell Regulation Of Cell Cycle Checkpoint MRNA Processing Negative Regulation Of DNA Damage Checkpoint Positive Regulation Of Gene Expression Viral Life Cycle Cellular Localization Viral Process RNA Processing Regulation Of DNA Damage Checkpoint RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Osteoblast Differentiation T Cell Differentiation Regulation Of Cell Cycle Process Nitrogen Compound Metabolic Process Positive Regulation Of DNA-templated Transcription, Elongation Negative Regulation Of Adaptive Immune Response B Cell Proliferation Lymphocyte Differentiation Positive Regulation Of Cell-cell Adhesion Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Cell Activation Regulation Of Translation Positive Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process T Cell Aggregation T Cell Activation Ossification Lymphocyte Aggregation Leukocyte Aggregation	MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Processing RNA Splicing MRNA Processing RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Viral Process RNA Biosynthetic Process SRP-dependent Cotranslational Protein Targeting To Membrane Termination Of RNA Polymerase II Transcription Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Cellular Macromolecule Biosynthetic Process Regulation Of MRNA Stability Regulation Of RNA Stability Macromolecule Biosynthetic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Protein Localization To Endoplasmic Reticulum Viral Life Cycle Cytoplasmic Transport Posttranscriptional Regulation Of Gene Expression MRNA Stabilization RNA 3'-end Processing MRNA 3'-end Processing RNA Catabolic Process Viral Transcription Cellular Metabolic Process Protein Targeting To Membrane DNA-templated Transcription, Termination Protein Targeting Nuclear-transcribed MRNA Catabolic Process Establishment Of Protein Localization To Organelle MRNA Catabolic Process Ribonucleoprotein Complex Assembly Regulation Of Translation Ribonucleoprotein Complex Biogenesis Biosynthetic Process Protein Localization To Organelle Translational Termination Establishment Of Protein Localization To Membrane Intracellular Transport Translational Elongation
Tagcloud ?		ablated amyotrophic atg biosamples c9orf72 crosslinking dipeptide exclusive expansions export foci ggggcc ggggcc5 hnrnp inappropriate irreversible lateral licensing messenger missing proteome pulldown repeat rnase sclerosis sequester sequestration srsf2 ultraviolet	aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Difference) ?		ablated amyotrophic atg biosamples c9orf72 crosslinking dipeptide exclusive expansions export foci ggggcc ggggcc5 hnrnp inappropriate irreversible lateral licensing messenger missing proteome pulldown repeat rnase sclerosis sequester sequestration srsf2 ultraviolet	aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Intersection) ?