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ZNF197 and VHL
Number of citations of the paper that reports this interaction (PMID
12682018
)
20
Data Source:
BioGRID
(two hybrid, pull down, affinity chromatography technology)
HPRD
(in vitro, in vivo)
ZNF197
VHL
Gene Name
zinc finger protein 197
von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleus
Nucleoplasm
Mitochondrion
Endoplasmic Reticulum
Cytosol
Membrane
Intermediate Filament Cytoskeleton
Molecular Function
DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Metal Ion Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Transcription Factor Binding
Enzyme Binding
Ubiquitin Protein Ligase Activity
Biological Process
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Cell Morphogenesis
Regulation Of Transcription, DNA-templated
Proteolysis
Negative Regulation Of Cell Proliferation
Protein Ubiquitination
Negative Regulation Of Apoptotic Process
Positive Regulation Of Cell Differentiation
Positive Regulation Of Transcription, DNA-templated
Protein Stabilization
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Cellular Response To Hypoxia
Pathways
Generic Transcription Pathway
Cellular response to hypoxia
Antigen processing: Ubiquitination & Proteasome degradation
Regulation of Hypoxia-inducible Factor (HIF) by oxygen
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Class I MHC mediated antigen processing & presentation
Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions
4 interactors:
DISC1
NDEL1
TRIM28
VHL
85 interactors:
ACTB
APP
AR
AURKA
CAPN7
CAPZB
CBR1
CBX1
CBX3
CCT3
CD44
CDC34
CHEK2
CLU
CSNK2A1
CUL2
CUL5
DGKI
DNAJA3
DVL2
E2F1
EEF1B2
EPAS1
FKBP8
FLNA
FN1
HDAC1
HDAC2
HDAC3
HIF1A
HIF1AN
HIF3A
HIST1H1C
HIST1H2BL
HIST4H4
HNRNPA2B1
HNRNPD
HSPA5
HSPA8
JADE1
KIF2C
KIF3A
KLF4
LANCL1
MDFI
NCL
NR4A1
NR4A2
NR4A3
PDCD5
PLD1
POLR2G
PRDX1
PRKCD
PRKCI
PRMT1
PRMT8
PSMC3
RB1CC1
RBPMS
RBPMS2
RBX1
RNF139
RPL21
RPL5
RPS15A
SARNP
SAT2
SKP2
SLC2A1
SLC3A2
SON
SP1
TCEB1
TCEB2
TRIM28
UBE2D1
USP20
USP33
UXT
VAPB
VBP1
YY1AP1
ZNF197
ZNF512B
Entrez ID
10168
7428
HPRD ID
10322
01905
Ensembl ID
ENSG00000186448
Uniprot IDs
O14709
Q7Z6G1
P40337
PDB IDs
1LM8
1LQB
1VCB
3ZRC
3ZRF
3ZTC
3ZTD
3ZUN
4AJY
4AWJ
4B95
4B9K
Enriched GO Terms of Interacting Partners
?
Cerebral Cortex Radially Oriented Cell Migration
Cerebral Cortex Cell Migration
Telencephalon Cell Migration
Forebrain Cell Migration
Positive Regulation Of Cell Differentiation
Developmental Growth Involved In Morphogenesis
Cerebral Cortex Development
Neuron Migration
Negative Regulation Of DNA Demethylation
Cell Morphogenesis
Pallium Development
Positive Regulation Of Metabolic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Convergent Extension Involved In Axis Elongation
Developmental Growth
Telencephalon Development
Positive Regulation Of Axon Regeneration
Regulation Of Genetic Imprinting
DNA Methylation Involved In Embryo Development
Retrograde Axon Cargo Transport
Regulation Of Cell Differentiation
Positive Regulation Of Neuron Projection Regeneration
Activation Of Cdc42 GTPase Activity
Regulation Of Neuron Projection Development
Mitotic Centrosome Separation
Neurofilament Cytoskeleton Organization
Positive Regulation Of Neurogenesis
Centrosome Separation
Anatomical Structure Development
Microtubule Cytoskeleton Organization
Forebrain Development
Convergent Extension
Regulation Of Axon Regeneration
Regulation Of Cell Projection Organization
Growth
Negative Regulation Of Viral Release From Host Cell
Positive Regulation Of Cdc42 GTPase Activity
Positive Regulation Of Cell Development
In Utero Embryonic Development
Mitochondrial Calcium Ion Homeostasis
Developmental Process
Regulation Of Neuron Differentiation
Inner Cell Mass Cell Proliferation
Regulation Of Synapse Maturation
Protein Ubiquitination
Microtubule Nucleation
TOR Signaling
Regulation Of Viral Release From Host Cell
Protein Modification By Small Protein Conjugation
Regulation Of Cdc42 GTPase Activity
Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Response To Stress
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Gene Expression
Cellular Metabolic Process
RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Regulation Of Metabolic Process
Regulation Of RNA Biosynthetic Process
Regulation Of Nucleic Acid-templated Transcription
Regulation Of Transcription, DNA-templated
RNA Metabolic Process
Transcription, DNA-templated
Regulation Of Cellular Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Regulation Of DNA-templated Transcription In Response To Stress
Metabolic Process
Cellular Response To Stress
Positive Regulation Of Metabolic Process
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Cellular Response To Hypoxia
Cellular Response To Decreased Oxygen Levels
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Nucleobase-containing Compound Metabolic Process
Cellular Response To Oxygen Levels
Cellular Nitrogen Compound Metabolic Process
Negative Regulation Of Cell Death
Nitrogen Compound Metabolic Process
Positive Regulation Of Protein Metabolic Process
Blood Coagulation
Positive Regulation Of Cellular Protein Metabolic Process
Hemostasis
Heterocycle Metabolic Process
Positive Regulation Of Gene Expression
Cellular Aromatic Compound Metabolic Process
Regulation Of Apoptotic Process
Regulation Of Protein Metabolic Process
Transcription From RNA Polymerase II Promoter
Regulation Of Body Fluid Levels
Biosynthetic Process
Regulation Of Cellular Protein Metabolic Process
Regulation Of Cell Death
Regulation Of Transcription From RNA Polymerase II Promoter
Wound Healing
Regulation Of Signal Transduction
Response To Stimulus
Tagcloud
?
ankyrin
attenuates
bc
belonging
binds
box
collection
degenerate
elongation
elongin
hippel
inhibiting
initially
interacting
jak
lindau
motif
multifunctional
multiprotein
participates
pol
repeat
skp1
socs
spry
stat
suppressor
von
wd
Tagcloud (Difference)
?
ankyrin
attenuates
bc
belonging
binds
box
collection
degenerate
elongation
elongin
hippel
inhibiting
initially
interacting
jak
lindau
motif
multifunctional
multiprotein
participates
pol
repeat
skp1
socs
spry
stat
suppressor
von
wd
Tagcloud (Intersection)
?