KRT14 and PUS10

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRT14	PUS10
Description		keratin 14	pseudouridine synthase 10
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GO Annotations	Cellular Component	Cornified Envelope Nucleus Cytoplasm Cytosol Cytoskeleton Intermediate Filament Keratin Filament Basal Part Of Cell Extracellular Exosome Cell Periphery	Nucleus Cytoplasm Mitochondrion Cytosol
	Molecular Function	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Skin Epidermis Keratin Filament Binding	RNA Binding Protein Binding Pseudouridine Synthase Activity Isomerase Activity Metal Ion Binding Primary MiRNA Binding TRNA Pseudouridine Synthase Activity TRNA Pseudouridine(55) Synthase Activity
	Biological Process	Morphogenesis Of An Epithelium Epidermis Development Response To Radiation Keratinocyte Differentiation Hair Cycle Intermediate Filament Organization Intermediate Filament Bundle Assembly Stem Cell Differentiation	Pseudouridine Synthesis TRNA Processing RNA Modification Primary MiRNA Processing TRNA Pseudouridine Synthesis
Pathways		Type I hemidesmosome assembly Keratinization Formation of the cornified envelope Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin Developmental Lineage of Mammary Gland Myoepithelial Cells
Drugs		Zinc Zinc acetate
Diseases		Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic Dermatopathia pigmentosa reticularis Naegeli-Franceschetti-Jadassohn syndrome
GWAS			Atopic dermatitis ( 26482879) Celiac disease ( 22057235 25920553 30572963) Celiac disease and Rheumatoid arthritis ( 26546613) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 22412388 28067908) Crohn's disease and celiac disease ( 21298027) Erectile dysfunction ( 30583798) Inflammatory bowel disease ( 28067908) Multiple sclerosis ( 31604244) Ulcerative colitis ( 20228799 21297633 28067908)
Interacting Genes		35 interacting genes: ABI2 ABI3 AMOT APC BFSP2 CTTNBP2 DRC4 DST ENKD1 HGS HSPA5 KIFC3 KRT1 KRT3 KRT4 KRT5 KRT6C KRT72 KRT77 KRT78 KRT79 KRT80 KRT81 KRT85 KRT86 OIP5 PKP1 PRPH PUS10 SDCBP SMARCE1 TCHP TRADD UBASH3A USHBP1	4 interacting genes: KRT14 KRT16 NECAB2 USP25
Entrez ID		3861	150962
HPRD ID		01017	08126
Ensembl ID		ENSG00000186847	ENSG00000162927
Uniprot IDs		P02533	A8K6R4 Q3MIT2
PDB IDs		3TNU 6JFV	2V9K
Enriched GO Terms of Interacting Partners?		Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Intermediate Filament Organization Structural Constituent Of Skin Epidermis Intermediate Filament Keratin Filament Keratinization Cytoskeleton Organization Supramolecular Fiber Organization Organelle Organization Anchoring Junction Cytosol Cytoskeleton Extracellular Exosome Desmosome Cell-cell Junction Organization Cell Junction Organization Adherens Junction Polymeric Cytoskeletal Fiber Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Cell-cell Junction Assembly Actin-based Cell Projection Intermediate Filament Cytoskeleton Microtubule Binding Microtubule Cytoskeleton Cell Junction Assembly Cornified Envelope Protein Binding SCAR Complex Positive Regulation Of Exosomal Secretion Regulation Of Modification Of Postsynaptic Structure Structural Molecule Activity Signaling Adaptor Activity Lamellipodium Microtubule Regulation Of Exosomal Secretion Regulation Of Modification Of Synaptic Structure Microtubule Plus-end Binding Cell-cell Junction Maintenance Cytoskeletal Anchor Activity Structural Constituent Of Cytoskeleton Regulation Of Cell Projection Assembly Regulation Of Protein Folding In Endoplasmic Reticulum Intermediate Filament Polymerization Interleukin-5 Receptor Complex COP9 Signalosome	Hair Cycle Cornified Envelope Structural Constituent Of Skin Epidermis Keratinocyte Differentiation Intermediate Filament Organization Structural Constituent Of Cytoskeleton Intermediate Filament Cytoskeleton Organization Keratin Filament Epidermal Cell Differentiation Intermediate Filament-based Process Epidermis Development Negative Regulation Of G Protein-coupled Receptor Internalization Intermediate Filament Structural Molecule Activity Negative Regulation Of Interleukin-17-mediated Signaling Pathway Positive Regulation Of Adenosine Receptor Signaling Pathway A2A Adenosine Receptor Binding Type 5 Metabotropic Glutamate Receptor Binding Ubiquitin-like Protein Peptidase Activity Keratin Filament Binding Keratinocyte Migration Interleukin-17A-mediated Signaling Pathway Negative Regulation Of ERAD Pathway Intermediate Filament Bundle Assembly Morphogenesis Of An Epithelium Negative Regulation Of Response To Oxidative Stress Positive Regulation Of Glutamate Receptor Signaling Pathway SUMO Binding Regulation Of Glutamate Receptor Signaling Pathway Epithelial Cell Differentiation Tissue Morphogenesis Basal Part Of Cell Negative Regulation Of Receptor Internalization Regulation Of Amyloid Precursor Protein Biosynthetic Process Supramolecular Fiber Organization Protein K63-linked Deubiquitination Regulation Of ERAD Pathway Deubiquitinase Activity Protein K48-linked Deubiquitination Regulation Of Response To Oxidative Stress Negative Regulation Of Receptor-mediated Endocytosis Epithelial Cell Migration Establishment Of Skin Barrier Regulation Of Glycoprotein Biosynthetic Process Skin Epidermis Development Tissue Development Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Response To Endoplasmic Reticulum Stress
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