KRT14 and KRT85

Number of citations of the paper that reports this interaction (PubMedID 36949045)
82

Data Source:
BioGRID (two hybrid)

		KRT14	KRT85
Description		keratin 14	keratin 85
Image			No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Nucleus Cytoplasm Cytosol Cytoskeleton Intermediate Filament Keratin Filament Basal Part Of Cell Extracellular Exosome Cell Periphery	Extracellular Space Cytosol Intermediate Filament Keratin Filament
	Molecular Function	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Skin Epidermis Keratin Filament Binding	Structural Molecule Activity Protein Binding Structural Constituent Of Skin Epidermis
	Biological Process	Morphogenesis Of An Epithelium Epidermis Development Response To Radiation Keratinocyte Differentiation Hair Cycle Intermediate Filament Organization Intermediate Filament Bundle Assembly Stem Cell Differentiation	Epidermis Development Keratinization Intermediate Filament Organization
Pathways		Type I hemidesmosome assembly Keratinization Formation of the cornified envelope Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin Developmental Lineage of Mammary Gland Myoepithelial Cells	Keratinization Formation of the cornified envelope
Drugs		Zinc Zinc acetate
Diseases		Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic Dermatopathia pigmentosa reticularis Naegeli-Franceschetti-Jadassohn syndrome	Ectodermal dysplasia, pure hair-nail type (HNED)
GWAS			Body mass index ( 28552196)
Interacting Genes		35 interacting genes: ABI2 ABI3 AMOT APC BFSP2 CTTNBP2 DRC4 DST ENKD1 HGS HSPA5 KIFC3 KRT1 KRT3 KRT4 KRT5 KRT6C KRT72 KRT77 KRT78 KRT79 KRT80 KRT81 KRT85 KRT86 OIP5 PKP1 PRPH PUS10 SDCBP SMARCE1 TCHP TRADD UBASH3A USHBP1	27 interacting genes: ALOX12 CLIC3 CREB5 CYSRT1 GNE HAPLN2 KLHL38 KRT13 KRT14 KRT15 KRT16 KRT19 KRT25 KRT26 KRT27 KRT31 KRT33B KRT34 KRT35 KRT36 KRT37 KRT39 KRT40 LHX8 OTX1 TAB2 ZNF655
Entrez ID		3861	3891
HPRD ID		01017	04139
Ensembl ID		ENSG00000186847	ENSG00000135443
Uniprot IDs		P02533	B7Z7N3 F5GYI5 P78386
PDB IDs		3TNU 6JFV
Enriched GO Terms of Interacting Partners?		Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Intermediate Filament Organization Structural Constituent Of Skin Epidermis Intermediate Filament Keratin Filament Keratinization Cytoskeleton Organization Supramolecular Fiber Organization Organelle Organization Anchoring Junction Cytosol Cytoskeleton Extracellular Exosome Desmosome Cell-cell Junction Organization Cell Junction Organization Adherens Junction Polymeric Cytoskeletal Fiber Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Cell-cell Junction Assembly Actin-based Cell Projection Intermediate Filament Cytoskeleton Microtubule Binding Microtubule Cytoskeleton Cell Junction Assembly Cornified Envelope Protein Binding SCAR Complex Positive Regulation Of Exosomal Secretion Regulation Of Modification Of Postsynaptic Structure Structural Molecule Activity Signaling Adaptor Activity Lamellipodium Microtubule Regulation Of Exosomal Secretion Regulation Of Modification Of Synaptic Structure Microtubule Plus-end Binding Cell-cell Junction Maintenance Cytoskeletal Anchor Activity Structural Constituent Of Cytoskeleton Regulation Of Cell Projection Assembly Regulation Of Protein Folding In Endoplasmic Reticulum Intermediate Filament Polymerization Interleukin-5 Receptor Complex COP9 Signalosome	Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Structural Molecule Activity Morphogenesis Of An Epithelium Epithelial Cell Differentiation Tissue Morphogenesis Supramolecular Fiber Organization Cytoskeleton Organization Anatomical Structure Morphogenesis Cytoskeleton Extracellular Exosome Epidermis Development Cell Differentiation Hair Cycle Cellular Developmental Process Developmental Process Organelle Organization Structural Constituent Of Cytoskeleton Establishment Of Skin Barrier Skin Epidermis Development Cytosol Tissue Development Cornified Envelope Hair Follicle Morphogenesis Hepoxilin-epoxide Hydrolase Activity Lipoxin B4 Biosynthetic Process Protein Binding Diencephalon Morphogenesis N-acetylglucosamine Biosynthetic Process UDP-N-acetylglucosamine 2-epimerase Activity Leukotriene A4 Metabolic Process Lipoxin B4 Metabolic Process Linoleate 13S-lipoxygenase Activity Arachidonate 15-lipoxygenase Activity Lipoxin A4 Biosynthetic Process Intermediate Filament Cytoskeleton Protein-disulfide Reductase (glutathione) Activity N-acylmannosamine Kinase Activity N-acetylneuraminate Biosynthetic Process Lipoxin Biosynthetic Process Lipoxin A4 Metabolic Process Arachidonate 12(S)-lipoxygenase Activity Keratinocyte Differentiation Terminal Web Metencephalon Development Establishment Of Blood-nerve Barrier
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