TSSC4 and UBA1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		TSSC4	UBA1
Description		tumor suppressing subtransferable candidate 4	ubiquitin like modifier activating enzyme 1
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GO Annotations	Cellular Component	Nucleus Spliceosomal Complex U5 SnRNP Cytoplasm	Heterochromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Lysosomal Membrane Cytosol Endosome Membrane Desmosome Rough Endoplasmic Reticulum Membrane Extracellular Exosome
	Molecular Function	Protein Binding Protein-containing Complex Binding Molecular Sequestering Activity	Nucleotide Binding RNA Binding Ubiquitin Activating Enzyme Activity Protein Binding ATP Binding Ubiquitin-like Modifier Activating Enzyme Activity Ligase Activity
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly Spliceosomal SnRNP Assembly MRNA Processing RNA Splicing	Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Protein Ubiquitination
Pathways			Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs			Hexatantalum Dodecabromide Quercetin
Diseases			Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
GWAS		Malaria ( 31844061)
Interacting Genes		14 interacting genes: APP CEP76 GMCL1 GOLGA2 KPNA3 REL RNF31 SPTAN1 TAB1 TCF4 TERF2IP TRAF1 TRAF2 UBA1	51 interacting genes: ABCF1 AZGP1P2 BUB3 CDK1 CEBPA CHEK1 ECHS1 GAN GRB2 HGS HSPH1 LINC01554 MGMT MTNR1A OGT PIAS3 SEMA3F SMAD5 SUMO2 TAF9 TMCC2 TSSC4 TTC19 UBC UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G1 UBE2J1 UBE2J2 UBE2K UBE2L1 UBE2L3 UBE2L6 UBE2M UBE2N UBE2Q2 UBE2R2 UBE2S UBE2T UBE2U UBE2W UBE2Z UBTD2
Entrez ID		10078	7317
HPRD ID		10357	02440
Ensembl ID		ENSG00000184281	ENSG00000130985
Uniprot IDs		Q9Y5U2	A0A024R1A3 P22314
PDB IDs		7PX3 8Q7Q 8Q7V	4P22 6DC6 7PYV
Enriched GO Terms of Interacting Partners?		Positive Regulation Of NF-kappaB Transcription Factor Activity Non-canonical NF-kappaB Signal Transduction Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of DNA-binding Transcription Factor Activity Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Thioesterase Binding CD40 Signaling Pathway CD40 Receptor Complex Positive Regulation Of Intracellular Signal Transduction Identical Protein Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Protein-containing Complex Assembly Tumor Necrosis Factor Receptor Binding Intracellular Signaling Cassette Protein-containing Complex Organization Regulation Of Intracellular Signal Transduction Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cytoplasm TORC2 Complex Disassembly Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Acetylcholine Receptor Activator Activity PTB Domain Binding Positive Regulation Of Metabolic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Positive Regulation Of Neuron Differentiation Growth Cone Filopodium Lipoprotein Particle Cytosol Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Beta-catenin-TCF7L2 Complex Signaling Adaptor Activity Ubiquitin Protein Ligase Binding	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Ubiquitination Protein K48-linked Ubiquitination Ubiquitin-like Protein Transferase Activity Protein Modification Process Protein K11-linked Ubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process ATP Binding Transferase Activity Ubiquitin-dependent Protein Catabolic Process Nucleotide Binding Protein Metabolic Process Macromolecule Catabolic Process Proteolysis Ubiquitin Protein Ligase Binding Protein Monoubiquitination Macromolecule Metabolic Process Catabolic Process Protein K63-linked Ubiquitination Proteasomal Protein Catabolic Process Protein K6-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Nucleoplasm ISG15 Transferase Activity HULC Complex DNA Damage Response ISG15-protein Conjugation Regulation Of Post-translational Protein Modification Free Ubiquitin Chain Polymerization Nucleus DNA Repair Positive Regulation Of Post-translational Protein Modification Protein K29-linked Ubiquitination Cellular Response To Stress Cell Cycle Phase Transition Ubiquitin Binding Regulation Of Protein Modification Process Protein K27-linked Ubiquitination Positive Regulation Of Protein Ubiquitination Ubiquitin Ligase Complex Positive Regulation Of Protein Metabolic Process Regulation Of Protein Ubiquitination TORC1 Signaling DNA Metabolic Process
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