HUWE1 and USP4

  • Number of citations of the paper that reports this interaction (PMID 21522127)
  • 12
  • Data Source:
  • BioGRID (affinity chromatography technology, enzymatic study)

HUWE1

USP4

Gene Name HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase ubiquitin specific peptidase 4 (proto-oncogene)
Image
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions 20 interactors: ABL1 CALM1 CCL1 CDKN2A HDAC2 LAPTM5 MCL1 MYC PIAS2 POLB RNF11 SMAD2 SMAD9 TP53 UBE2D1 UBE2D2 UBE2D3 UBE2G1 UBE2L3 USP4 46 interactors: AKT1 ANXA7 ASS1 ATP1B1 ATP1B3 BRAP CDKN1A FAM96B HUWE1 IGKV2D-29 LAMA5 LGALS1 NLK NOLC1 NPC2 PCNA PDK1 PGM1 PLA2G2A PLOD1 PPIA PRPF3 PSAP PSMA6 PSMC5 PSMD11 RB1 RBL1 RBL2 RCC1 SART3 SMN1 TCF4 TGFBR1 TK1 TP53BP2 TRAF2 TRAF6 TRIM21 TRIM54 TRIM55 TRIM63 UBC USP15 USP21 USP28
Entrez ID 10075 7375
HPRD ID 06608 04598
Ensembl ID ENSG00000086758 ENSG00000114316
Uniprot IDs Q7Z6Z7 Q08AK7 Q13107
PDB IDs 2EKK 3G1N 3H1D 2Y6E
Enriched GO Terms of Interacting Partners?
Tagcloud ?
attractive  bicyclic  biol  catalyze  chem  cys  displacement  druggable  e2  e3  freund  heclin  hect  heinis  hek293  huge  kills  ligase  ligases  makes  mule  nat  phage  proven  rutherford  smurf2  thioesters  winter  wwp1 
1beta  adaptor  associates  deubiquitinase  deubiquitinates  deubiquitination  ectopic  ikappabalpha  importantly  incompletely  insight  interact  interacts  kappab  kappabalpha  negatively  nf  polyubiquitination  protease  reporter  signalling  tnfalpha  traf  traf2  traf3  traf6  ubiquitin  uncovers 
Tagcloud (Difference) ?
attractive  bicyclic  biol  catalyze  chem  cys  displacement  druggable  e2  e3  freund  heclin  hect  heinis  hek293  huge  kills  ligase  ligases  makes  mule  nat  phage  proven  rutherford  smurf2  thioesters  winter  wwp1 
1beta  adaptor  associates  deubiquitinase  deubiquitinates  deubiquitination  ectopic  ikappabalpha  importantly  incompletely  insight  interact  interacts  kappab  kappabalpha  negatively  nf  polyubiquitination  protease  reporter  signalling  tnfalpha  traf  traf2  traf3  traf6  ubiquitin  uncovers 
Tagcloud (Intersection) ?