USP4 and SART3

Number of citations of the paper that reports this interaction (PMID 20595234)
35

Data Source:
BioGRID (pull down, two hybrid)

		USP4	SART3
Gene Name		ubiquitin specific peptidase 4 (proto-oncogene)	squamous cell carcinoma antigen recognized by T cells 3
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Plasma Membrane	Nucleus Nucleoplasm U6atac SnRNP Cytoplasm Cajal Body Nuclear Speck U4/U6 X U5 Tri-snRNP Complex U4/U6 SnRNP U4atac/U6atac SnRNP
	Molecular Function	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Adenosine Receptor Binding Identical Protein Binding Metal Ion Binding	Nucleotide Binding Protein Binding U6 SnRNA Binding U4 SnRNA Binding U6atac SnRNA Binding Histone Binding Poly(A) RNA Binding Ubiquitin-specific Protease Binding
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly Protein Deubiquitination Negative Regulation Of Protein Ubiquitination Regulation Of Protein Stability Protein Localization To Cell Surface Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process	Spliceosomal Tri-snRNP Complex Assembly Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome Cell Morphogenesis Nucleosome Assembly Regulation Of Gene Expression Homeostasis Of Number Of Cells Hematopoietic Stem Cell Proliferation Positive Regulation Of Histone Deubiquitination
Pathways
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		46 interactors: AKT1 ANXA7 ASS1 ATP1B1 ATP1B3 BRAP CDKN1A FAM96B HUWE1 IGKV2D-29 LAMA5 LGALS1 NLK NOLC1 NPC2 PCNA PDK1 PGM1 PLA2G2A PLOD1 PPIA PRPF3 PSAP PSMA6 PSMC5 PSMD11 RB1 RBL1 RBL2 RCC1 SART3 SMN1 TCF4 TGFBR1 TK1 TP53BP2 TRAF2 TRAF6 TRIM21 TRIM54 TRIM55 TRIM63 UBC USP15 USP21 USP28	12 interactors: AR C6 COIL HIST2H2AC HIST2H2BE KPNA2 LSM7 MEGF10 PRPF3 RNPS1 USP15 USP4
Entrez ID		7375	9733
HPRD ID		04598	11532
Ensembl ID		ENSG00000114316	ENSG00000075856
Uniprot IDs		Q08AK7 Q13107	B7ZKM0 Q15020
PDB IDs		2Y6E	2DO4
Enriched GO Terms of Interacting Partners?		G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Apoptotic Process Cell Cycle Response To Stress Programmed Cell Death Cell Death Death Response To Stimulus Protein Polyubiquitination Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Signal Transduction By P53 Class Mediator Positive Regulation Of Cell Cycle Protein Ubiquitination Mitotic Cell Cycle Protein Catabolic Process Protein Modification By Small Protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Immune System Process Proteasomal Protein Catabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Proteolysis Cell Cycle Process Regulation Of Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Catalytic Activity Positive Regulation Of Transferase Activity Positive Regulation Of Proteolysis Regulation Of Lipid Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Negative Regulation Of Transferase Activity Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Regulation Of Catalytic Activity Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Intracellular Signal Transduction Negative Regulation Of Cell Cycle Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Cell Cycle Checkpoint Cellular Response To Stimulus Mitotic G1 DNA Damage Checkpoint Ubiquitin-dependent Protein Catabolic Process	RNA Splicing Spliceosomal Tri-snRNP Complex Assembly MRNA Processing MRNA Metabolic Process RNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Spliceosomal SnRNP Assembly Cellular Macromolecule Catabolic Process Negative Regulation Of Integrin Biosynthetic Process Skeletal Muscle Satellite Cell Proliferation Skeletal Muscle Cell Proliferation Histone H2B Conserved C-terminal Lysine Deubiquitination Skeletal Muscle Satellite Cell Activation Protein Deubiquitination Protein Modification By Small Protein Removal Positive Regulation Of Integrin Biosynthetic Process Positive Regulation Of Activation Of Membrane Attack Complex Regulation Of Integrin Biosynthetic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Cellular Macromolecular Complex Assembly Ribonucleoprotein Complex Assembly Skeletal Muscle Satellite Cell Differentiation RNA Catabolic Process Recognition Of Apoptotic Cell Regulation Of Proteasomal Protein Catabolic Process Monoubiquitinated Protein Deubiquitination Positive Regulation Of Transcription From RNA Polymerase III Promoter Humoral Immune Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Nucleocytoplasmic Transport Pathway-restricted SMAD Protein Phosphorylation Nuclear Transport Catabolic Process Positive Regulation Of Humoral Immune Response
Tagcloud ?		1beta adaptor associates deubiquitinase deubiquitinates deubiquitination ectopic ikappabalpha importantly incompletely insight interact interacts kappab kappabalpha negatively nf polyubiquitination protease reporter signalling tnfalpha traf traf2 traf3 traf6 ubiquitin uncovers	a24 alleles antigen antigens attempted bc cd8 ctls efficiently enhancer epitope ezh2735 hla homolog igg immunotherapy leukocyte mononuclear mrp3 mrp31293 multidrug panel peptides polycomb reactive rejection thereafter zeste
Tagcloud (Difference) ?		1beta adaptor associates deubiquitinase deubiquitinates deubiquitination ectopic ikappabalpha importantly incompletely insight interact interacts kappab kappabalpha negatively nf polyubiquitination protease reporter signalling tnfalpha traf traf2 traf3 traf6 ubiquitin uncovers	a24 alleles antigen antigens attempted bc cd8 ctls efficiently enhancer epitope ezh2735 hla homolog igg immunotherapy leukocyte mononuclear mrp3 mrp31293 multidrug panel peptides polycomb reactive rejection thereafter zeste
Tagcloud (Intersection) ?