USP4 and CIAO2B

Number of citations of the paper that reports this interaction (PubMedID 23022198)
0

Data Source:
BioGRID (two hybrid)

		USP4	CIAO2B
Description		ubiquitin specific peptidase 4	cytosolic iron-sulfur assembly component 2B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Cytosol	Nucleus Nucleoplasm Cytoplasm Spindle Cytosol Cytoskeleton Midbody MMXD Complex Cytosolic [4Fe-4S] Assembly Targeting Complex
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Adenosine Receptor Binding Identical Protein Binding Metal Ion Binding	Protein Binding
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly Cytoplasmic Translation Proteolysis Cellular Response To Starvation Protein Deubiquitination Negative Regulation Of Protein Ubiquitination Regulation Of Protein Stability Cellular Response To Nutrient Levels Protein Localization To Cell Surface TORC1 Signaling Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling	Chromosome Segregation Protein Maturation
Pathways		TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Ub-specific processing proteases	Cytosolic iron-sulfur cluster assembly
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Glycated hemoglobin levels ( 34059833 28898252) High light scatter reticulocyte percentage of red cells ( 27863252) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908 23128233) Intelligence (MTAG) ( 29326435) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Red cell distribution width ( 32888494) Refractive error ( 32231278) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252 32888494) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908 25082827)
Interacting Genes		49 interacting genes: AKT1 ANXA7 ASS1 ATP1B1 ATP1B3 BDKRB2 BRAP CDKN1A CIAO2B DLC1 HDAC2 IGKV2D-29 IRF4 LAMA5 LGALS1 MAP3K7 NLK NOLC1 NPC2 PCNA PDK1 PGM1 PLA2G2A PLOD1 PPIA PRPF3 PSAP PSMA6 PSMC5 PSMD11 RB1 RBBP8 RBL1 RBL2 RCC1 RHEB RNPS1 SMAD4 SMN1 TK1 TP53BP2 TRAF2 TRIM21 TRIM54 TRIM55 TRIM63 UBC USP21 USP28	6 interacting genes: CIAO1 DSCAM ERRFI1 MTNR1A PAXIP1 USP4
Entrez ID		7375	51647
HPRD ID		04598	13033
Ensembl ID		ENSG00000114316	ENSG00000166595
Uniprot IDs		Q08AK7 Q13107	Q9Y3D0
PDB IDs		2Y6E 5CTR
Enriched GO Terms of Interacting Partners?		Regulation Of Lipid Kinase Activity Intracellular Signal Transduction Nucleoplasm Regulation Of Phosphorus Metabolic Process Regulation Of Catalytic Activity Intracellular Signaling Cassette Macromolecule Metabolic Process Extracellular Exosome PCNA-p21 Complex Regulation Of Kinase Activity Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Response To Stress Nucleus Identical Protein Binding Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Phosphorylation Positive Regulation Of Catalytic Activity TORC1 Signaling Regulation Of Cell Cycle Apoptotic Signaling Pathway Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Deoxyribonuclease Activity Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cell Cycle Phase Transition Protein-containing Complex Cytoplasm Cytosol Response To External Biotic Stimulus Negative Regulation Of Cell Cycle Signal Transduction Positive Regulation Of Potassium Ion Import Across Plasma Membrane Sulfate Binding Cellular Response To Stress G1/S Transition Of Mitotic Cell Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle TOR Signaling Cell Cycle G1/S Phase Transition Positive Regulation Of Sodium Ion Transport NF-kappaB Binding Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Potassium Ion Import Cellular Response To Chemical Stress Protein Modification Process Negative Regulation Of Cell Cycle Process Epithelial Cell Differentiation DNA-binding Transcription Factor Binding Positive Regulation Of Interleukin-2 Production Cell Differentiation Regulation Of Cell Cycle G1/S Phase Transition
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