USP4 and PPIA

Number of citations of the paper that reports this interaction (PMID 23022198)
1

Data Source:
BioGRID (two hybrid)

		USP4	PPIA
Gene Name		ubiquitin specific peptidase 4 (proto-oncogene)	peptidylprolyl isomerase A (cyclophilin A)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Plasma Membrane	Extracellular Region Extracellular Space Nucleus Cytosol Focal Adhesion Membrane Extracellular Vesicular Exosome
	Molecular Function	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Adenosine Receptor Binding Identical Protein Binding Metal Ion Binding	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Peptide Binding Poly(A) RNA Binding Virion Binding Unfolded Protein Binding
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly Protein Deubiquitination Negative Regulation Of Protein Ubiquitination Regulation Of Protein Stability Protein Localization To Cell Surface Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process	Protein Peptidyl-prolyl Isomerization Platelet Degranulation RNA-dependent DNA Replication Protein Folding Blood Coagulation Viral Process Viral Life Cycle Uncoating Of Virus Virion Assembly Viral Release From Host Cell Platelet Activation Entry Into Host Cell Lipid Particle Organization Regulation Of Viral Genome Replication Positive Regulation Of Viral Genome Replication Positive Regulation Of Protein Secretion Leukocyte Migration Establishment Of Integrated Proviral Latency
Pathways			HIV Infection Host Interactions of HIV factors Integration of provirus Platelet degranulation Basigin interactions Late Phase of HIV Life Cycle Cell surface interactions at the vascular wall Uncoating of the HIV Virion Early Phase of HIV Life Cycle Reverse Transcription of HIV RNA Assembly Of The HIV Virion HIV Life Cycle Budding and maturation of HIV virion Response to elevated platelet cytosolic Ca2+ Minus-strand DNA synthesis Platelet activation, signaling and aggregation Binding and entry of HIV virion Plus-strand DNA synthesis APOBEC3G mediated resistance to HIV-1 infection
Drugs			Cyclosporine L-Proline (3r)-1-Acetyl-3-Methylpiperidine Ethyl Oxo(Piperidin-1-Yl)Acetate (3s,6s,9r,10r,11s,12s,13e,15e,18s,21s)-18-{(1e,3e,7s,8s)-9-[(2s,3r,4s,5s,6r,9s,11s)-9-Ethyl-4-Hydroxy-3,5,11-Trimethyl-8-Oxo-1-Oxa-7-Azaspiro[5.5]Undec-2-Yl]-8-Hydroxy-1,7-Dimethylnona-1,3-Dienyl}-10,12-Dihydroxy-3-(3-Hydroxybenzyl)-6-Isopropyl-11-Methyl-
Diseases
GWAS		Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		46 interactors: AKT1 ANXA7 ASS1 ATP1B1 ATP1B3 BRAP CDKN1A FAM96B HUWE1 IGKV2D-29 LAMA5 LGALS1 NLK NOLC1 NPC2 PCNA PDK1 PGM1 PLA2G2A PLOD1 PPIA PRPF3 PSAP PSMA6 PSMC5 PSMD11 RB1 RBL1 RBL2 RCC1 SART3 SMN1 TCF4 TGFBR1 TK1 TP53BP2 TRAF2 TRAF6 TRIM21 TRIM54 TRIM55 TRIM63 UBC USP15 USP21 USP28	22 interactors: APP BSG CD99 ITK JAK2 LIG4 LNX1 NOTCH3 PAXIP1 PRLR PRR13 PRSS23 PTPRN RB1 S100A8 SRPK1 SRPK2 SUPT5H TCF4 TERT USP4 YY1
Entrez ID		7375	5478
HPRD ID		04598	00457
Ensembl ID		ENSG00000114316	ENSG00000196262
Uniprot IDs		Q08AK7 Q13107	P62937 Q567Q0
PDB IDs		2Y6E	1AK4 1AWQ 1AWR 1AWS 1AWT 1AWU 1AWV 1BCK 1CWA 1CWB 1CWC 1CWF 1CWH 1CWI 1CWJ 1CWK 1CWL 1CWM 1CWO 1FGL 1M63 1M9C 1M9D 1M9E 1M9F 1M9X 1M9Y 1MF8 1MIK 1NMK 1OCA 1RMH 1VBS 1VBT 1W8L 1W8M 1W8V 1YND 1ZKF 2ALF 2CPL 2CYH 2RMA 2RMB 2X25 2X2A 2X2C 2X2D 2XGY 3CYH 3CYS 3K0M 3K0N 3K0O 3K0P 3K0Q 3K0R 3ODI 3ODL 3RDD 4CYH 5CYH
Enriched GO Terms of Interacting Partners?		G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Apoptotic Process Cell Cycle Response To Stress Programmed Cell Death Cell Death Death Response To Stimulus Protein Polyubiquitination Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Signal Transduction By P53 Class Mediator Positive Regulation Of Cell Cycle Protein Ubiquitination Mitotic Cell Cycle Protein Catabolic Process Protein Modification By Small Protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Immune System Process Proteasomal Protein Catabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Proteolysis Cell Cycle Process Regulation Of Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Catalytic Activity Positive Regulation Of Transferase Activity Positive Regulation Of Proteolysis Regulation Of Lipid Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Negative Regulation Of Transferase Activity Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Regulation Of Catalytic Activity Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Intracellular Signal Transduction Negative Regulation Of Cell Cycle Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Cell Cycle Checkpoint Cellular Response To Stimulus Mitotic G1 DNA Damage Checkpoint Ubiquitin-dependent Protein Catabolic Process	Chromosome Organization RNA Metabolic Process Activation Of JAK2 Kinase Activity Cellular Metabolic Process Positive Regulation Of Gene Expression Immune System Process RNA Processing Cell Differentiation Positive Regulation Of Metabolic Process Response To Stress Gene Expression Regulation Of Gene Expression Cellular Response To Stimulus Activation Of Janus Kinase Activity Neuron Apoptotic Process Organ Development Regulation Of RNA Metabolic Process DNA Metabolic Process Neuron Death Chromatin Organization Organelle Organization MRNA Processing Nucleobase-containing Compound Metabolic Process Positive Regulation Of Viral Process Response To Stimulus Developmental Process Protein Metabolic Process Positive Regulation Of Peptide Secretion Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Innate Immune Response Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Anatomical Structure Development System Development Regulation Of Nitrogen Compound Metabolic Process Metabolic Process Cellular Nitrogen Compound Metabolic Process Immune Response MRNA Metabolic Process Leukocyte Aggregation Positive Regulation Of Proteolysis Cellular Component Assembly Chromatin Modification Leukocyte Cell-cell Adhesion Positive Regulation Of Viral Genome Replication Regulation Of Sequence-specific DNA Binding Transcription Factor Activity JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Homotypic Cell-cell Adhesion Response To Organic Substance
Tagcloud ?		1beta adaptor associates deubiquitinase deubiquitinates deubiquitination ectopic ikappabalpha importantly incompletely insight interact interacts kappab kappabalpha negatively nf polyubiquitination protease reporter signalling tnfalpha traf traf2 traf3 traf6 ubiquitin uncovers	ape1 apparently beetroot breaks cdkn2a consumed defenses differing formulations gexp gss hdls ho1 homeostatic il6 interindividual investigates occasions postprandial ptgs2 saturated scope sirt socs3 strand stratified ucp2 unsaturated volunteers
Tagcloud (Difference) ?		1beta adaptor associates deubiquitinase deubiquitinates deubiquitination ectopic ikappabalpha importantly incompletely insight interact interacts kappab kappabalpha negatively nf polyubiquitination protease reporter signalling tnfalpha traf traf2 traf3 traf6 ubiquitin uncovers	ape1 apparently beetroot breaks cdkn2a consumed defenses differing formulations gexp gss hdls ho1 homeostatic il6 interindividual investigates occasions postprandial ptgs2 saturated scope sirt socs3 strand stratified ucp2 unsaturated volunteers
Tagcloud (Intersection) ?