BCL2L10 and BECN1

Number of citations of the paper that reports this interaction (PubMedID 22498477)
38

Data Source:
BioGRID (pull down)

		BCL2L10	BECN1
Description		BCL2 like 10	beclin 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Spindle Cytosol Cytoskeleton Membrane Nuclear Membrane Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site	Phagophore Assembly Site Nucleus Cytoplasm Mitochondrion Endosome Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Cytosol Endosome Membrane Membrane Nuclear Body Dendrite Cytoplasmic Vesicle Mitochondrial Membrane Cytoplasmic Side Of Mitochondrial Outer Membrane Protein-containing Complex Phosphatidylinositol 3-kinase Complex, Class III, Type I Phosphatidylinositol 3-kinase Complex, Class III, Type II Phosphatidylinositol 3-kinase Complex, Class III Phagocytic Vesicle
	Molecular Function	Calcium Ion Binding Protein Binding Channel Activity Caspase Binding	Protein Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Phosphatidylinositol 3-kinase Binding GTPase Binding Molecular Adaptor Activity
	Biological Process	Release Of Cytochrome C From Mitochondria Apoptotic Process Spermatogenesis Female Gamete Generation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Microtubule Organizing Center Organization Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Transmembrane Transport Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Autophagosome Assembly Mitophagy Response To Hypoxia Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein Targeting To Lysosome Endocytosis Autophagy Apoptotic Process Cellular Defense Response Cellular Response To Nitrogen Starvation Lysosome Organization Mitotic Metaphase Chromosome Alignment JNK Cascade Circadian Rhythm Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Iron(II) Ion Response To Lead Ion Regulation Of Autophagy Negative Regulation Of Autophagy Positive Regulation Of Autophagy Positive Regulation Of Cardiac Muscle Hypertrophy Macroautophagy Regulation Of Macroautophagy Response To Nutrient Levels Regulation Of Cytokinesis Receptor Catabolic Process Response To Vitamin E Cellular Response To Amino Acid Starvation Phosphatidylinositol-3-phosphate Biosynthetic Process P38MAPK Cascade Cellular Response To Glucose Starvation Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Engulfment Of Apoptotic Cell Early Endosome To Late Endosome Transport Late Endosome To Vacuole Transport Neuron Development Amyloid-beta Metabolic Process Cell Division Defense Response To Virus Response To Other Organism Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction SMAD Protein Signal Transduction Positive Regulation Of Stress Granule Assembly Protein-containing Complex Assembly Cellular Response To Hydrogen Peroxide Cellular Response To Aluminum Ion Cellular Response To Copper Ion Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Oxygen-glucose Deprivation Autophagosome Maturation Response To Mitochondrial Depolarisation Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Negative Regulation Of Autophagosome Assembly Negative Regulation Of Lysosome Organization Positive Regulation Of Autophagosome Assembly Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			ISG15 antiviral mechanism Macroautophagy Ub-specific processing proteases Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex SARS-CoV-2 activates/modulates innate and adaptive immune responses Antigen Presentation: Folding, assembly and peptide loading of class I MHC RSV-host interactions
Drugs			Estradiol Estradiol acetate Estradiol benzoate Estradiol cypionate Estradiol dienanthate Estradiol valerate
Diseases
GWAS			Type 2 diabetes (age of onset) ( 28060188)
Interacting Genes		14 interacting genes: APAF1 BAD BAK1 BAX BCL2 BCL2L1 BCL2L11 BECN1 BMF CASP8 MGST2 NR4A1 SAMD4B TMEM200A	61 interacting genes: AKT1 AMBRA1 ARAF ARNT BCL2 BCL2L1 BCL2L10 BTK CASP3 CCND2 CDK4 CDK6 CDKN2A CDKN2B EPHA2 ERBB2 FGFR4 FRS2 FZR1 GFI1B GLIS2 GOPC GRM1 HERC5 HSPB6 ITCH ITPR1 ITPR3 ITSN1 KAT2A KDELR2 KLHL20 LATS2 MAP2K3 MAP2K5 MAP2K6 MAPKAPK2 MAPKAPK3 MDM4 MST1 NF2 NLRP6 NXF1 PDGFRA PGK1 RACK1 RAF1 RIPK2 SENP3 SHD SMAD2 STK11 STYK1 TEAD2 TERT TSC1 UBC ULK1 WASHC1 XPO1 YES1
Entrez ID		10017	8678
HPRD ID		06071	05087
Ensembl ID		ENSG00000137875	ENSG00000126581
Uniprot IDs		H0YMD5 Q9HD36	A0A024R1X5 B4DQ36 E7EV84 Q14457 W0FFG4
PDB IDs		4B4S	2P1L 2PON 3DVU 4DDP 4MI8 5EFM 5HHE 5VAU 5VAX 5VAY 6DCN 6DCO 6HOI 6HOJ 6HOK 7BL1 8SOR 9C82 9MHF 9MHG 9MHH
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Bcl-2 Family Protein Complex Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Release Of Cytochrome C From Mitochondria Mitochondrial Outer Membrane Extrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrial Membrane Permeability Apoptotic Process Release Of Cytochrome C From Mitochondria Cell Death Programmed Cell Death Apoptotic Mitochondrial Changes Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Membrane Permeability Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Mitochondrial Membrane Organization Regulation Of Apoptotic Signaling Pathway Regulation Of Mitochondrion Organization Leukocyte Apoptotic Process Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Mitochondrial Membrane Potential Regulation Of Intrinsic Apoptotic Signaling Pathway B Cell Homeostasis T Cell Apoptotic Process BH3 Domain Binding Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Lymphocyte Apoptotic Process Positive Regulation Of IRE1-mediated Unfolded Protein Response Channel Activity Mitochondrion Organization Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Thymocyte Apoptotic Process Response To Gamma Radiation B Cell Apoptotic Process Positive Regulation Of Apoptotic Signaling Pathway Calcium Ion Transport Into Cytosol Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Pore Complex Regulation Of Developmental Pigmentation Lymphocyte Homeostasis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of IRE1-mediated Unfolded Protein Response Mitochondrial Membrane Reproductive Structure Development Membrane Organization Leukocyte Homeostasis	Protein Kinase Activity Kinase Activity Intracellular Signal Transduction Protein Tyrosine Kinase Activity Protein Serine Kinase Activity Regulation Of Cell Population Proliferation ATP Binding Regulation Of Signal Transduction Signal Transduction Cellular Response To Stress Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cell Cycle Protein Serine/threonine Kinase Activity Regulation Of Apoptotic Process Transferase Activity Cytoplasm Regulation Of Programmed Cell Death Protein Modification Process Cytosol Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Communication Regulation Of Protein Modification Process Positive Regulation Of Signaling Nucleotide Binding Regulation Of Developmental Process Cell Population Proliferation Intracellular Signaling Cassette Regulation Of Protein Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Autophagy Protein Metabolic Process Response To Stress Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Population Proliferation Regulation Of Phosphorylation Negative Regulation Of Apoptotic Process Regulation Of Cell Differentiation Animal Organ Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of Catalytic Activity Negative Regulation Of Multicellular Organismal Process Regulation Of Epithelial Cell Proliferation
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