BCL2L10 and BCL2L11

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		BCL2L10	BCL2L11
Description		BCL2 like 10	BCL2 like 11
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Spindle Cytosol Cytoskeleton Membrane Nuclear Membrane Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Microtubule Endomembrane System Membrane Intracellular Membrane-bounded Organelle Bcl-2 Family Protein Complex BIM-BCL-xl Complex BIM-BCL-2 Complex
	Molecular Function	Calcium Ion Binding Protein Binding Channel Activity Caspase Binding	Protein Binding Microtubule Binding Protein Kinase Binding
	Biological Process	Release Of Cytochrome C From Mitochondria Apoptotic Process Spermatogenesis Female Gamete Generation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Microtubule Organizing Center Organization Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Transmembrane Transport Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	In Utero Embryonic Development Leukocyte Homeostasis B Cell Homeostasis Kidney Development Lymphocyte Homeostasis Myeloid Cell Homeostasis Apoptotic Process Meiosis I Cell-matrix Adhesion Spermatogenesis Male Gonad Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Post-embryonic Development Mammary Gland Development Positive Regulation Of Protein-containing Complex Assembly Response To Endoplasmic Reticulum Stress Tube Formation Odontogenesis Of Dentin-containing Tooth Regulation Of Apoptotic Process T Cell Homeostasis Positive Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Ear Development Positive Regulation Of Cell Cycle Regulation Of Organ Growth Developmental Pigmentation Regulation Of Developmental Pigmentation Spleen Development Thymus Development Lymphocyte Apoptotic Process Positive Regulation Of Lymphocyte Apoptotic Process T Cell Apoptotic Process Positive Regulation Of T Cell Apoptotic Process Thymocyte Apoptotic Process Cellular Response To Glucocorticoid Stimulus Positive Regulation Of Release Of Cytochrome C From Mitochondria Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Apoptotic Process Involved In Embryonic Digit Morphogenesis Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			Activation of BIM and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members NRAGE signals death through JNK Signaling by BRAF and RAF1 fusions Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models RUNX3 regulates BCL2L11 (BIM) transcription FLT3 Signaling FOXO-mediated transcription of cell death genes
Drugs
Diseases
GWAS			A body shape index ( 34021172) Allergic disease (asthma, hay fever or eczema) ( 29083406) Alopecia areata ( 25608926) Asthma ( 30929738 32296059) Asthma (childhood onset) ( 30929738) B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Breast cancer ( 29059683) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Chronic lymphocytic leukemia ( 24292274 28165464 23770605 26956414 18758461) Composite immunoglobulin trait (IgA x IgG/IgM) ( 28628107) Dehydroepiandrosterone sulphate levels ( 21533175) Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Eosinophilic granulomatosis with polyangiitis ( 31719529) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Immature fraction of reticulocytes ( 27863252) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Multiple sclerosis ( 31604244) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Primary sclerosing cholangitis ( 27992413 21151127) Prostate cancer ( 29892016) Prostate cancer (advanced) ( 29892016) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494 27863252) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 33272962) Triglyceride levels ( 32203549) Type 2 diabetes ( 30054458 28869590) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408) Urinary albumin-to-creatinine ratio ( 32600054) Vitiligo ( 27723757) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		14 interacting genes: APAF1 BAD BAK1 BAX BCL2 BCL2L1 BCL2L11 BECN1 BMF CASP8 MGST2 NR4A1 SAMD4B TMEM200A	31 interacting genes: AKT1 APP ATP6V1G1 AURKB BCL2 BCL2A1 BCL2L1 BCL2L10 BCL2L2 BTK CDK1 DTX2 DYNLL1 FEM1C FGL1 GTF2I MAGEA11 MAPK10 MAPK8 MAPK9 MCL1 MEX3D MKRN3 PEX19 RACK1 RIOK3 SMARCB1 TRIM2 USHBP1 VDAC1 YWHAB
Entrez ID		10017	10018
HPRD ID		06071	04828
Ensembl ID		ENSG00000137875	ENSG00000153094
Uniprot IDs		H0YMD5 Q9HD36	A0A0C4DH20 E9PAM9 H7BZE5 O43521
PDB IDs		4B4S	1F95 2K7W 2NL9 2V6Q 2VM6 2WH6 2YQ6 2YQ7 3D7V 3FDL 3IO8 3IO9 3KJ0 3KJ1 3KJ2 4A1U 4A1W 4B4S 4D2M 4QVF 4UF3 4YJ4 4ZIE 4ZIF 4ZIH 5AGW 5AGX 5C3G 5VWV 5VWW 5VWX 5VWY 5VWZ 5VX0 5VX2 5VX3 5WOS 6QFI 6RJP 6TQQ 6UA3 6UAB 6VBX 6X8O 8T5E
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Bcl-2 Family Protein Complex Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Release Of Cytochrome C From Mitochondria Mitochondrial Outer Membrane Extrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrial Membrane Permeability Apoptotic Process Release Of Cytochrome C From Mitochondria Cell Death Programmed Cell Death Apoptotic Mitochondrial Changes Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Membrane Permeability Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Mitochondrial Membrane Organization Regulation Of Apoptotic Signaling Pathway Regulation Of Mitochondrion Organization Leukocyte Apoptotic Process Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Mitochondrial Membrane Potential Regulation Of Intrinsic Apoptotic Signaling Pathway B Cell Homeostasis T Cell Apoptotic Process BH3 Domain Binding Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Lymphocyte Apoptotic Process Positive Regulation Of IRE1-mediated Unfolded Protein Response Channel Activity Mitochondrion Organization Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Thymocyte Apoptotic Process Response To Gamma Radiation B Cell Apoptotic Process Positive Regulation Of Apoptotic Signaling Pathway Calcium Ion Transport Into Cytosol Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Pore Complex Regulation Of Developmental Pigmentation Lymphocyte Homeostasis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of IRE1-mediated Unfolded Protein Response Mitochondrial Membrane Reproductive Structure Development Membrane Organization Leukocyte Homeostasis	Release Of Cytochrome C From Mitochondria Apoptotic Mitochondrial Changes Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Channel Activity BH3 Domain Binding Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Bcl-2 Family Protein Complex Positive Regulation Of Apoptotic Process Apoptotic Process Positive Regulation Of Programmed Cell Death Programmed Cell Death Cell Death Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage JUN Kinase Activity Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Extrinsic Apoptotic Signaling Pathway Mitochondrial Outer Membrane Apoptotic Signaling Pathway Fc-epsilon Receptor Signaling Pathway Mitochondrion Organization Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Response To Radiation Regulation Of Intrinsic Apoptotic Signaling Pathway Intracellular Signal Transduction Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Response To Light Stimulus Post-translational Protein Modification Mitochondrion Protein Modification Process Cytosol Protein Serine Kinase Activity MAP Kinase Activity Fc Receptor Signaling Pathway Regulation Of Autophagy Regulation Of Immune Response Negative Regulation Of Anoikis Regulation Of Apoptotic Signaling Pathway Regulation Of Neuron Apoptotic Process Regulation Of B Cell Apoptotic Process Protein Serine/threonine Kinase Activity Negative Regulation Of Metabolic Process Peptidyl-threonine Phosphorylation Immune Response-regulating Signaling Pathway DNA Damage Response Dendritic Cell Apoptotic Process Response To Reactive Oxygen Species Immune Response-regulating Cell Surface Receptor Signaling Pathway
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