SRA1 and HAND1

Number of citations of the paper that reports this interaction (PMID 20398657)
4

Data Source:
BioGRID (far western blotting)

		SRA1	HAND1
Gene Name		steroid receptor RNA activator 1	heart and neural crest derivatives expressed 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Plasma Membrane Microtubule Cytoskeleton Ribonucleoprotein Complex Intercellular Bridge	Nucleus Nucleoplasm Nucleolus Cytoplasm RNA Polymerase II Transcription Factor Complex
	Molecular Function	Transcription Coactivator Activity Protein Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Enzyme Binding Identical Protein Binding Protein Homodimerization Activity BHLH Transcription Factor Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Apoptotic Process Cell Proliferation Cell Differentiation Regulation Of Apoptotic Process Positive Regulation Of Receptor Activity	Negative Regulation Of Transcription From RNA Polymerase II Promoter Angiogenesis Mesoderm Formation Blastocyst Development Trophectodermal Cell Differentiation Heart Looping Embryonic Heart Tube Formation Cardiac Left Ventricle Formation Cardiac Right Ventricle Formation Transcription From RNA Polymerase II Promoter Heart Development Embryonic Heart Tube Development Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Septum Morphogenesis Mesenchyme Development Cartilage Morphogenesis Trophoblast Giant Cell Differentiation Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
Pathways
Drugs
Diseases
GWAS			Ventricular conduction ( 21076409)
Protein-Protein Interactions		33 interactors: ALX1 ATF1 ATF2 ATF3 ATF4 BLZF1 BTG2 CEBPA CREB1 DDIT3 DDX17 DMTF1 E2F3 EGR1 EGR2 ESR1 ESR2 ESRRG ETS1 ETS2 FOS FOSB FOSL2 GATA1 GTF2B GTF2H2 GTF3C5 HAND1 NCOA2 NR3C1 RXRB TFAP2A UBE2Z	13 interactors: ACHE FHL2 HAND2 HEY2 HEYL MEF2A MYOD1 PPP2R5D PRKACA PRKCA SRA1 TCF12 TCF3
Entrez ID		10011	9421
HPRD ID		18716	03871
Ensembl ID		ENSG00000213523	ENSG00000113196
Uniprot IDs		Q9HD15	O96004
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Response To Hormone Regulation Of Metabolic Process Response To Organic Cyclic Compound Negative Regulation Of Gene Expression Cellular Response To Organic Substance Response To Organic Substance Cellular Response To Hormone Stimulus Response To Steroid Hormone Cellular Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Skeletal Muscle Cell Differentiation System Development DNA-templated Transcription, Initiation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Tissue Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Striated Muscle Tissue Development Response To Lipid Organ Development	Muscle Structure Development Positive Regulation Of Cellular Biosynthetic Process Cell Differentiation Tissue Development Transcription From RNA Polymerase II Promoter Muscle Organ Development Developmental Process Organ Development Cardiac Chamber Development System Development Regulation Of Cell Differentiation Outflow Tract Morphogenesis Gene Expression Multicellular Organismal Development Cell Development Positive Regulation Of Cellular Metabolic Process Cardiac Ventricle Morphogenesis Anatomical Structure Development Ventricular Cardiac Muscle Cell Development Heart Morphogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cell Differentiation Cardiovascular System Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Dense Core Granule Biogenesis Cardiac Ventricle Development Positive Regulation Of Gene Expression Ventricular Cardiac Muscle Cell Differentiation Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Nervous System Development Transcription, DNA-templated Anatomical Structure Formation Involved In Morphogenesis Striated Muscle Tissue Development Stem Cell Differentiation Muscle Cell Differentiation RNA Biosynthetic Process Muscle Tissue Development Tissue Morphogenesis Cardiocyte Differentiation Positive Regulation Of Metabolic Process Mesenchymal Cell Differentiation Heart Valve Morphogenesis Histone H3-T6 Phosphorylation Heart Valve Development Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Muscle Cell Differentiation Striated Muscle Cell Development Cellular Macromolecule Biosynthetic Process Biosynthetic Process
Tagcloud ?		activator adipocyte adipose biology coactivator coding diet droplets evidenced fasting fat feeding fewer glucoses homeostasis ip knock lean lipogenesis livers obesity organs ppargamma promotes regulator steroid subset tnfalpha	accessible cardiogenesis cardiomyogenesis competence confers corepressors decommissioned dispensable divergence ectopic emerges enhancers epigenetically exclusive exploits fates gata4 hemogenic landscape mesoderm multipotent mutually occupying opposing orchestrated pioneer prevents primed recruiting
Tagcloud (Difference) ?		activator adipocyte adipose biology coactivator coding diet droplets evidenced fasting fat feeding fewer glucoses homeostasis ip knock lean lipogenesis livers obesity organs ppargamma promotes regulator steroid subset tnfalpha	accessible cardiogenesis cardiomyogenesis competence confers corepressors decommissioned dispensable divergence ectopic emerges enhancers epigenetically exclusive exploits fates gata4 hemogenic landscape mesoderm multipotent mutually occupying opposing orchestrated pioneer prevents primed recruiting
Tagcloud (Intersection) ?