SRA1 and GTF2H2

Number of citations of the paper that reports this interaction (PMID 20398657)
4

Data Source:
BioGRID (far western blotting)

		SRA1	GTF2H2
Gene Name		steroid receptor RNA activator 1	general transcription factor IIH, polypeptide 2, 44kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Plasma Membrane Microtubule Cytoskeleton Ribonucleoprotein Complex Intercellular Bridge	Core TFIIH Complex Nucleoplasm Holo TFIIH Complex
	Molecular Function	Transcription Coactivator Activity Protein Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity	Nucleic Acid Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Kinase Activity Protein Binding DNA-dependent ATPase Activity Translation Factor Activity, Nucleic Acid Binding Zinc Ion Binding RNA Polymerase II Carboxy-terminal Domain Kinase Activity Protein N-terminus Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Apoptotic Process Cell Proliferation Cell Differentiation Regulation Of Apoptotic Process Positive Regulation Of Receptor Activity	Nucleotide-excision Repair, DNA Damage Removal G-protein Coupled Receptor Internalization DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Translation Protein Phosphorylation Response To UV Gene Expression Viral Process Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Viral Transcription
Pathways			RNA Polymerase II Promoter Escape Formation of HIV-1 elongation complex containing HIV-1 Tat Nucleotide Excision Repair RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Chain Elongation RNA Polymerase II Transcription RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance HIV Infection Formation of the Early Elongation Complex Tat-mediated elongation of the HIV-1 transcript Formation of transcription-coupled NER (TC-NER) repair complex RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events Dual incision reaction in TC-NER NoRC negatively regulates rRNA expression HIV Transcription Initiation HIV Life Cycle RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II HIV Promoter Escape HIV Transcription Elongation Dual incision reaction in GG-NER mRNA Capping RNA Polymerase I Transcription RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex Global Genomic NER (GG-NER) RNA Polymerase II Transcription Initiation And Promoter Clearance Transcription-coupled NER (TC-NER) Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of incision complex in GG-NER RNA Polymerase II Transcription Initiation Transcription of the HIV genome RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS
Protein-Protein Interactions		33 interactors: ALX1 ATF1 ATF2 ATF3 ATF4 BLZF1 BTG2 CEBPA CREB1 DDIT3 DDX17 DMTF1 E2F3 EGR1 EGR2 ESR1 ESR2 ESRRG ETS1 ETS2 FOS FOSB FOSL2 GATA1 GTF2B GTF2H2 GTF3C5 HAND1 NCOA2 NR3C1 RXRB TFAP2A UBE2Z	9 interactors: AR CDK7 ERCC2 ERCC3 ERCC8 GTF2H1 GTF2H3 GTF2H5 SRA1
Entrez ID		10011	2966
HPRD ID		18716	03450
Ensembl ID		ENSG00000213523	ENSG00000145736
Uniprot IDs		Q9HD15	Q13888
PDB IDs			1Z60
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Response To Hormone Regulation Of Metabolic Process Response To Organic Cyclic Compound Negative Regulation Of Gene Expression Cellular Response To Organic Substance Response To Organic Substance Cellular Response To Hormone Stimulus Response To Steroid Hormone Cellular Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Skeletal Muscle Cell Differentiation System Development DNA-templated Transcription, Initiation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Tissue Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Striated Muscle Tissue Development Response To Lipid Organ Development	Transcription Elongation From RNA Polymerase I Promoter Nucleotide-excision Repair Transcription From RNA Polymerase I Promoter Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair, DNA Damage Removal Termination Of RNA Polymerase I Transcription DNA-templated Transcription, Elongation Transcription Initiation From RNA Polymerase I Promoter 7-methylguanosine MRNA Capping 7-methylguanosine RNA Capping Positive Regulation Of Viral Transcription Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Regulation Of Viral Transcription Positive Regulation Of Viral Process DNA-templated Transcription, Termination Negative Regulation Of Gene Expression, Epigenetic DNA-templated Transcription, Initiation DNA Repair DNA Catabolic Process Regulation Of Viral Process Cellular Response To DNA Damage Stimulus MRNA Processing Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression, Epigenetic MRNA Metabolic Process DNA Metabolic Process RNA Processing Transcription, DNA-templated RNA Biosynthetic Process Cellular Response To Stress Cellular Macromolecule Catabolic Process Aromatic Compound Catabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Viral Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Gene Expression Nitrogen Compound Metabolic Process Nucleotide-excision Repair, DNA Incision Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription, DNA-templated
Tagcloud ?		activator adipocyte adipose biology coactivator coding diet droplets evidenced fasting fat feeding fewer glucoses homeostasis ip knock lean lipogenesis livers obesity organs ppargamma promotes regulator steroid subset tnfalpha	acetylation bioflavonoid ccna2 ccnd1 cdkn1a chip crna ddx5 epigenetic esp estrogenic h4 immunoprecipitation involving luteolin mcf microarray modified ncoa3 ncor1 nras nrip1 pcna plk plk1 polr2a proliferative qpcr taf9
Tagcloud (Difference) ?		activator adipocyte adipose biology coactivator coding diet droplets evidenced fasting fat feeding fewer glucoses homeostasis ip knock lean lipogenesis livers obesity organs ppargamma promotes regulator steroid subset tnfalpha	acetylation bioflavonoid ccna2 ccnd1 cdkn1a chip crna ddx5 epigenetic esp estrogenic h4 immunoprecipitation involving luteolin mcf microarray modified ncoa3 ncor1 nras nrip1 pcna plk plk1 polr2a proliferative qpcr taf9
Tagcloud (Intersection) ?