SRA1 and TFAP2A

Number of citations of the paper that reports this interaction (PubMedID 20398657)
0

Data Source:
BioGRID (far western blotting)

		SRA1	TFAP2A
Description		steroid receptor RNA activator 1	transcription factor AP-2 alpha
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cilium Microtubule Cytoskeleton Intercellular Bridge Ribonucleoprotein Complex	Chromatin Nucleus Nucleoplasm
	Molecular Function	Steroid Receptor RNA Activator RNA Binding Transcription Coactivator Activity Protein Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Apoptotic Process Negative Regulation Of Myoblast Differentiation Positive Regulation Of DNA-templated Transcription	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Kidney Development Optic Vesicle Morphogenesis Optic Cup Structural Organization Regulation Of DNA-templated Transcription Nervous System Development Sensory Perception Of Sound Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Retina Layer Formation Negative Regulation Of Transcription By Competitive Promoter Binding Trigeminal Nerve Development Oculomotor Nerve Formation Positive Regulation Of Bone Mineralization Embryonic Forelimb Morphogenesis Regulation Of Cell Population Proliferation Inner Ear Morphogenesis Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Regulation Of Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Cranial Skeleton Morphogenesis Roof Of Mouth Development Bone Morphogenesis Eyelid Development In Camera-type Eye Positive Regulation Of Tooth Mineralization Cellular Response To Iron Ion Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways			Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors TFAP2 (AP-2) family regulates transcription of other transcription factors Activation of the TFAP2 (AP-2) family of transcription factors TFAP2 (AP-2) family regulates transcription of growth factors and their receptors TFAP2 (AP-2) family regulates transcription of cell cycle factors TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation Positive Regulation of CDH1 Gene Transcription Regulation of MITF-M-dependent genes involved in pigmentation Specification of the neural plate border Specification of the neural plate border Developmental Lineage of Mammary Stem Cells
Drugs
Diseases			Branchiooculofacial syndrome (BOFS)
GWAS		Refractive error ( 32231278) Schizophrenia ( 28991256) Serum immune biomarker levels ( 32066700)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Breast cancer in BRCA2 mutation carriers ( 23544012) Glucose homeostasis traits ( 25524916) Iron status biomarkers (ferritin levels) ( 28334935) Metabolite levels ( 23823483) Ovarian cancer ( 30557369) Refractive error ( 32231278) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261) Zinc levels ( 26025379)
Interacting Genes		30 interacting genes: ALX1 ATF1 ATF2 ATF3 ATF4 BLZF1 BTG2 CEBPA CREB1 DDIT3 DMTF1 E2F3 EGR1 EGR2 ESR1 ESR2 ESRRG ETS1 ETS2 FOS FOSB FOSL2 GATA1 GTF2B GTF2H2 GTF3C5 HAND1 NR3C1 TFAP2A UBE2Z	40 interacting genes: APC CASP1 CASP3 CASP6 CITED2 CITED4 CLTC CSNK2A1 CSNK2B CTNNB1 DEK EP300 EPN1 EPN2 EPS15 GSTO2 HIP1 INCA1 KCTD15 LDLRAP1 MAGI1 MARK1 MKRN3 MYC NFKB1 NPM1 OCRL PPARG PRKAA2 PRKD1 RB1 SRA1 SUMO4 SYT1 TP53 UBE2I VEGFA WWP1 WWP2 YBX1
Entrez ID		10011	7020
HPRD ID		18716	00128
Ensembl ID		ENSG00000213523	ENSG00000137203
Uniprot IDs		Q9HD15	A0A6E1XE14 P05549
PDB IDs		2MGX 4NBO	8J0K 8J0L 8J0R
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Factor Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Transcription By RNA Polymerase II DNA Binding Regulation Of Transcription By RNA Polymerase II Sequence-specific Double-stranded DNA Binding Positive Regulation Of RNA Metabolic Process RNA Polymerase II Transcription Regulator Complex RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Cis-regulatory Region Binding Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Biosynthetic Process Nucleus Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Transcription By RNA Polymerase II Macromolecule Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of Macromolecule Metabolic Process Skeletal Muscle Cell Differentiation Regulation Of Metabolic Process Estrogen Response Element Binding Negative Regulation Of Macromolecule Biosynthetic Process Promoter-specific Chromatin Binding Negative Regulation Of Biosynthetic Process Response To Hormone ATF4-CREB1 Transcription Factor Complex	Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Cytoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Signaling Negative Regulation Of RNA Metabolic Process Regulation Of Apoptotic Process Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Primary Metabolic Process Cell Death Negative Regulation Of DNA-templated Transcription Programmed Cell Death Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Clathrin Binding Cell Surface Receptor Signaling Pathway Identical Protein Binding Positive Regulation Of Cell Communication Regulation Of Macromolecule Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Nucleus Regulation Of Signaling Regulation Of Metabolic Process Transcription Coregulator Binding Regulation Of Protein Localization Regulation Of Signal Transduction Signal Transduction Cytosol Myeloid Cell Differentiation Chromatin Binding Glial Cell Apoptotic Process Negative Regulation Of Transcription By RNA Polymerase II Wnt Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Cell Communication RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription By RNA Polymerase II Disordered Domain Specific Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription Apoptotic Signaling Pathway Negative Regulation Of Protein Metabolic Process
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