SRA1 and ATF1

Number of citations of the paper that reports this interaction (PMID 20398657)
4

Data Source:
BioGRID (far western blotting)

		SRA1	ATF1
Gene Name		steroid receptor RNA activator 1	activating transcription factor 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Plasma Membrane Microtubule Cytoskeleton Ribonucleoprotein Complex Intercellular Bridge	Nucleus Nucleoplasm ATF1-ATF4 Transcription Factor Complex
	Molecular Function	Transcription Coactivator Activity Protein Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Complex Binding Protein Heterodimerization Activity
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Apoptotic Process Cell Proliferation Cell Differentiation Regulation Of Apoptotic Process Positive Regulation Of Receptor Activity	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription From RNA Polymerase II Promoter Positive Regulation Of Neuron Projection Development Response To Organic Cyclic Compound Response To Cobalt Ion Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Cellular Protein Complex Assembly Innate Immune Response Positive Regulation Of DNA Replication Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Stress-activated MAPK Cascade
Pathways			CREB phosphorylation Toll Like Receptor 7/8 (TLR7/8) Cascade CREB phosphorylation Toll Like Receptor TLR6:TLR2 Cascade Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade Innate Immune System Signalling by NGF TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade MAPK targets/ Nuclear events mediated by MAP kinases Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS			Colorectal cancer ( 20972440) Sudden cardiac arrest ( 21658281)
Protein-Protein Interactions		33 interactors: ALX1 ATF1 ATF2 ATF3 ATF4 BLZF1 BTG2 CEBPA CREB1 DDIT3 DDX17 DMTF1 E2F3 EGR1 EGR2 ESR1 ESR2 ESRRG ETS1 ETS2 FOS FOSB FOSL2 GATA1 GTF2B GTF2H2 GTF3C5 HAND1 NCOA2 NR3C1 RXRB TFAP2A UBE2Z	20 interactors: BRCA1 CAMK1 CAMK2A CAMK2G CREB1 CREBBP CREM CSNK2A1 CSNK2A2 CSNK2B EDF1 GABPA GABPB1 HNF1B JUN PRKACA RPS6KA4 RPS6KA5 SPI1 SRA1
Entrez ID		10011	466
HPRD ID		18716	00440
Ensembl ID		ENSG00000213523	ENSG00000123268
Uniprot IDs		Q9HD15	P18846
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Response To Hormone Regulation Of Metabolic Process Response To Organic Cyclic Compound Negative Regulation Of Gene Expression Cellular Response To Organic Substance Response To Organic Substance Cellular Response To Hormone Stimulus Response To Steroid Hormone Cellular Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Skeletal Muscle Cell Differentiation System Development DNA-templated Transcription, Initiation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Tissue Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Striated Muscle Tissue Development Response To Lipid Organ Development	Cell Differentiation Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Developmental Process Multicellular Organismal Development Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Chromosome Organization Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Anatomical Structure Development Protein Phosphorylation Negative Regulation Of Biosynthetic Process Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Regulation Of Histone Acetylation Phosphorylation Response To Cytokine RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Protein Modification Process Axon Development Regulation Of Myeloid Cell Differentiation Gene Expression Chemotaxis Positive Regulation Of Histone Acetylation Negative Regulation Of Gene Expression Nervous System Development Cell Development Cellular Macromolecule Biosynthetic Process Axon Guidance Apoptotic Process Positive Regulation Of Peptidyl-lysine Acetylation Negative Regulation Of Chromosome Organization Macromolecule Biosynthetic Process Positive Regulation Of Protein Acetylation Programmed Cell Death Anatomical Structure Morphogenesis
Tagcloud ?		activator adipocyte adipose biology coactivator coding diet droplets evidenced fasting fat feeding fewer glucoses homeostasis ip knock lean lipogenesis livers obesity organs ppargamma promotes regulator steroid subset tnfalpha	cascades creb erk2 ester esters exclude fgf k1 k2 km mapk2 mapkap mc mirror msk1 ngf p90rsk pc12 phorbol phosphorylates pka polypeptide ro sapk2 sb ser133 sk suppresses unstimulated
Tagcloud (Difference) ?		activator adipocyte adipose biology coactivator coding diet droplets evidenced fasting fat feeding fewer glucoses homeostasis ip knock lean lipogenesis livers obesity organs ppargamma promotes regulator steroid subset tnfalpha	cascades creb erk2 ester esters exclude fgf k1 k2 km mapk2 mapkap mc mirror msk1 ngf p90rsk pc12 phorbol phosphorylates pka polypeptide ro sapk2 sb ser133 sk suppresses unstimulated
Tagcloud (Intersection) ?