FBXL12 - New-wiki

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	MARCHF2	membrane associated ring-CH-type finger 2
Novel	SHFL	shiftless antiviral inhibitor of ribosomal frameshifting
Novel	ZNF44	zinc finger protein 44
Novel	ZNF562	zinc finger protein 562	Generic Transcription Pathway
Novel	ZNF823	zinc finger protein 823
	A2M	alpha-2-macroglobulin	Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Degradation of the extracellular matrix HDL assembly	Becaplermin Cisplatin Bacitracin Zinc Ocriplasmin Silver Zinc acetate Zinc chloride Zinc sulfate, unspecified form
	ALDH3A1	aldehyde dehydrogenase 3 family member A1	Phase I - Functionalization of compounds	NADH
	APOE	apolipoprotein E	Nuclear signaling by ERBB4 Scavenging by Class A Receptors Scavenging by Class A Receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors Post-translational protein phosphorylation Chylomicron assembly Chylomicron remodeling Chylomicron clearance Chylomicron clearance HDL remodeling NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Retinoid metabolism and transport Retinoid metabolism and transport Amyloid fiber formation	Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Alzheimer's disease (AD) Hyperlipoproteinemia, type III; Dysbetalipoproteinemia Lipoprotein glomerulopathy
	CDC37	cell division cycle 37, HSP90 cochaperone	Signaling by ERBB2 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Constitutive Signaling by EGFRvIII Regulation of necroptotic cell death Downregulation of ERBB2 signaling RHOBTB2 GTPase cycle Constitutive Signaling by Overexpressed ERBB2 Drug-mediated inhibition of ERBB2 signaling Signaling by ERBB2 KD Mutants Resistance of ERBB2 KD mutants to trastuzumab Resistance of ERBB2 KD mutants to sapitinib Resistance of ERBB2 KD mutants to tesevatinib Resistance of ERBB2 KD mutants to neratinib Resistance of ERBB2 KD mutants to osimertinib Resistance of ERBB2 KD mutants to afatinib Resistance of ERBB2 KD mutants to AEE788 Resistance of ERBB2 KD mutants to lapatinib Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Drug resistance in ERBB2 TMD/JMD mutants
	CDKN1C	cyclin dependent kinase inhibitor 1C	Cyclin D associated events in G1 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)		Beckwith-Wiedemann syndrome Adrenal carcinoma
	DOCK8	dedicator of cytokinesis 8	CDC42 GTPase cycle RAC1 GTPase cycle RHOJ GTPase cycle Factors involved in megakaryocyte development and platelet production		Non-syndromic autosomal dominant mental retardation
	ECSIT	ECSIT signaling integrator	MyD88:MAL(TIRAP) cascade initiated on plasma membrane Complex I biogenesis TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 cascade initiated on plasma membrane
	FBF1	Fas binding factor 1	Anchoring of the basal body to the plasma membrane
	FXYD3	FXYD domain containing ion transport regulator 3	Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS
	GEMIN4	gem nuclear organelle associated protein 4	snRNP Assembly SARS-CoV-2 modulates host translation machinery
	LNX1	ligand of numb-protein X 1	Antigen processing: Ubiquitination & Proteasome degradation
	MAST1	microtubule associated serine/threonine kinase 1		Fostamatinib
	PSEN1	presenilin 1	Nuclear signaling by ERBB4 Degradation of the extracellular matrix Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells Neutrophil degranulation NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 TGFBR3 PTM regulation		Alzheimer's disease (AD) Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3) Acne inversa; Hidradenitis supprativa
	PSEN2	presenilin 2	Nuclear signaling by ERBB4 Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 TGFBR3 PTM regulation		Alzheimer's disease (AD)
	PSME3	proteasome activator subunit 3	Proteasome assembly

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